Salivary microbiome composition changes after bariatric surgery
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33208788
PubMed Central
PMC7674438
DOI
10.1038/s41598-020-76991-6
PII: 10.1038/s41598-020-76991-6
Knihovny.cz E-zdroje
- MeSH
- Bacteria klasifikace genetika izolace a purifikace MeSH
- bariatrická chirurgie metody MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- metagenom * MeSH
- mikrobiota * MeSH
- obezita chirurgie MeSH
- RNA ribozomální 16S analýza MeSH
- sliny mikrobiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- RNA ribozomální 16S MeSH
Recent studies show that the salivary microbiome in subjects with obesity differ from those without obesity, but the mechanism of interaction between the salivary microbiome composition and body weight is unclear. Herein we investigate this relation by analyzing saliva samples from 35 adult patients with obesity undergoing bariatric surgery. Our aim was to describe salivary microbiome changes during body weight loss on an individual-specific level, and to elucidate the effect of bariatric surgery on the salivary microbiome which has not been studied before. Analysis of samples collected before and 1 day after surgery, as well as 3 and 12 months after surgery, showed that the salivary microbiome changed in all study participants, but these changes were heterogeneous. In the majority of participants proportions of Gemella species, Granulicatella elegans, Porphyromonas pasteri, Prevotella nanceiensis and Streptococcus oralis decreased, while Veillonella species, Megasphaera micronuciformis and Prevotella saliva increased. Nevertheless, we found participants deviating from this general trend which suggests that a variety of individual-specific factors influence the salivary microbiome composition more effectively than the body weight dynamics alone. The observed microbiome alternations could be related to dietary changes. Therefore, further studies should focus on association with altered taste preferences and potential oral health consequences.
CIBER in Epidemiology and Public Health Madrid Spain
Department of Bariatric Surgery Břeclav Hospital Břeclav Czech Republic
Department of Energy Joint Genome Institute Lawrence Berkeley National Laboratory Berkeley CA USA
Institute for Integrative Systems Biology Valencia Spain
Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia
Zobrazit více v PubMed
Hruby A, Hu FB. The epidemiology of obesity: A big picture. Pharmacoeconomics. 2015;33:673–689. doi: 10.1007/s40273-014-0243-x. PubMed DOI PMC
Ng M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–781. doi: 10.1016/S0140-6736(14)60460-8. PubMed DOI PMC
Turnbaugh PJ, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–1031. doi: 10.1038/nature05414. PubMed DOI
Zhao L. The gut microbiota and obesity: From correlation to causality. Nat. Rev. Microbiol. 2013;11:639–647. doi: 10.1038/nrmicro3089. PubMed DOI
Fetissov SO. Role of the gut microbiota in host appetite control: Bacterial growth to animal feeding behaviour. Nat. Rev. Endocrinol. 2017;13:11–25. doi: 10.1038/nrendo.2016.150. PubMed DOI
Muscogiuri G, et al. Gut microbiota: A new path to treat obesity. Int. J. Obes. Suppl. 2019;9:10–19. doi: 10.1038/s41367-019-0011-7. PubMed DOI PMC
Zeigler CC, et al. Microbiota in the oral subgingival biofilm is associated with obesity in adolescence. Obesity. 2012;20:157–164. doi: 10.1038/oby.2011.305. PubMed DOI
Goodson JM, et al. The salivary microbiome is altered in the presence of a high salivary glucose concentration. PLoS ONE. 2017;12:e0170437. doi: 10.1371/journal.pone.0170437. PubMed DOI PMC
Janem WF, et al. Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes. PLoS ONE. 2017;12:e0172647. doi: 10.1371/journal.pone.0172647. PubMed DOI PMC
Mervish NA, et al. Associations of the oral microbiota with obesity and menarche in inner city girls. J. Child. Obes. 2019;4:2. PubMed PMC
Raju SC, et al. Gender-specific associations between saliva microbiota and body size. Front. Microbiol. 2019;10:767. doi: 10.3389/fmicb.2019.00767. PubMed DOI PMC
Wang RR, et al. Association of the oral microbiome with the progression of impaired fasting glucose in a Chinese elderly population. J. Oral. Microbiol. 2019;11:1605789. doi: 10.1080/20002297.2019.1605789. PubMed DOI PMC
Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota–gut–brain communication. Nat. Rev. Gastroenterol. Hepatol. 2019;16:461–478. doi: 10.1038/s41575-019-0157-3. PubMed DOI
Hoffman KL, et al. Oral microbiota reveals signs of acculturation in Mexican American women. PLoS ONE. 2018;13:e0194100. doi: 10.1371/journal.pone.0194100. PubMed DOI PMC
Wu Y, Chi X, Zhang Q, Chen F, Deng X. Characterization of the salivary microbiome in people with obesity. PeerJ. 2018;6:e4458. doi: 10.7717/peerj.4458. PubMed DOI PMC
Duvallet C, Gibbons SM, Gurry T, Irizarry RA, Alm EJ. Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat. Commun. 2017;8:1784. doi: 10.1038/s41467-017-01973-8. PubMed DOI PMC
Gibbons SM. Defining microbiome health through a host lens. mSystems. 2019;4:e00155. doi: 10.1128/mSystems.00155-19. PubMed DOI PMC
Adams TD, et al. Weight and metabolic outcomes 12 years after gastric bypass. N. Engl. J. Med. 2017;377:1143–1155. doi: 10.1056/NEJMoa1700459. PubMed DOI PMC
Pories WJ. Bariatric surgery: Risks and rewards. J. Clin. Endocrinol. Metab. 2008;93:S89–S96. doi: 10.1210/jc.2008-1641. PubMed DOI PMC
Schauer PR, Nor Hanipah Z, Rubino F. Metabolic surgery for treating type 2 diabetes mellitus: Now supported by the world's leading diabetes organizations. Cleve Clin. J. Med. 2017;84:S47–S56. doi: 10.3949/ccjm.84.s1.06. PubMed DOI
Damms-Machado A, et al. Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption. Biomed. Res. Int. 2015;2015:806248. doi: 10.1155/2015/806248. PubMed DOI PMC
Tremaroli V, et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab. 2015;22:228–238. doi: 10.1016/j.cmet.2015.07.009. PubMed DOI PMC
Ilhan ZE, et al. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. ISME J. 2017;11:2047–2058. doi: 10.1038/ismej.2017.71. PubMed DOI PMC
Elliott JA, Reynolds JV, le Roux CW, Docherty NG. Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake. Expert Rev. Endocrinol. Metab. 2016;6:475–499. doi: 10.1080/17446651.2016.1245140. PubMed DOI
Sweeney TE, Morton JM. Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature. Best Pract. Res. Clin. Gastroenterol. 2014;28:727–740. doi: 10.1016/j.bpg.2014.07.016. PubMed DOI PMC
Paganelli FL, et al. Roux-Y gastric bypass and sleeve gastrectomy directly change gut microbiota composition independent of surgery type. Sci. Rep. 2019;9:10979. doi: 10.1038/s41598-019-47332-z. PubMed DOI PMC
Li JV, et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 2011;60:1214–1223. doi: 10.1136/gut.2010.234708. PubMed DOI PMC
Davies NK, O'Sullivan JM, Plank LD, Murphy R. Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review. Surg. Obes. Relat. Dis. 2019;15:656–665. doi: 10.1016/j.soard.2019.01.033. PubMed DOI
Guo Y, et al. Modulation of the gut microbiome: A systematic review of the effect of bariatric surgery. Eur. J. Endocrinol. 2018;178:43–56. doi: 10.1530/EJE-17-0403. PubMed DOI
Shillitoe E, et al. The oral microflora in obesity and type-2 diabetes. J. Oral Microbiol. 2012;4:19013. doi: 10.3402/jom.v4i0.19013. PubMed DOI PMC
Marsicano JA, et al. Interfaces between bariatric surgery and oral health: A longitudinal survey. Acta Cir. Bras. 2011;26:79–83. doi: 10.1590/S0102-86502011000800015. PubMed DOI
Hashizume LN, et al. Impact of bariatric surgery on the saliva of patients with morbid obesity. Obes. Surg. 2015;25:1550–1555. doi: 10.1007/s11695-015-1741-4. PubMed DOI
El-Hadi M, Birch DW, Gill RS, Karmali S. The effect of bariatric surgery on gastroesophageal reflux disease. Can. J. Surg. 2014;57:139–144. doi: 10.1503/cjs.030612. PubMed DOI PMC
Sujatha S, et al. Oral pH in gastroesophageal reflux disease. Indian J. Gastroenterol. 2016;35:186–189. doi: 10.1007/s12664-016-0659-7. PubMed DOI
Zhou J, et al. Influences of pH and iron concentration on the salivary microbiome in individual humans with and without caries. Appl. Environ. Microbiol. 2017;83:e02412–e2416. PubMed PMC
Cattaneo C, et al. New insights into the relationship between taste perception and oral microbiota composition. Sci. Rep. 2019;9:3549. doi: 10.1038/s41598-019-40374-3. PubMed DOI PMC
Cabral DJ, et al. The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization. Sci. Rep. 2017;7:11040. doi: 10.1038/s41598-017-11427-2. PubMed DOI PMC
Lloyd-Price J, et al. Strains, functions and dynamics in the expanded human microbiome project. Nature. 2017;550:61–66. doi: 10.1038/nature23889. PubMed DOI PMC
Džunková M, et al. Oxidative stress in the oral cavity is driven by individual-specific bacterial communities. NPJ Biofilms Microbiomes. 2018;4:29. doi: 10.1038/s41522-018-0072-3. PubMed DOI PMC
Hall MW, et al. Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity. NPJ Biofilms Microbiomes. 2017;3:2. doi: 10.1038/s41522-016-0011-0. PubMed DOI PMC
Yan Q, et al. Alterations of the gut microbiome in hypertension. Front. Cell. Infect. Microbiol. 2017;7:381. doi: 10.3389/fcimb.2017.00381. PubMed DOI PMC
Medina DA, et al. Cross-regional view of functional and taxonomic microbiota composition in obesity and post-obesity treatment shows country specific microbial contribution. Front. Microbiol. 2019;10:2346. doi: 10.3389/fmicb.2019.02346. PubMed DOI PMC
Aron-Wisnewsky J, et al. Major microbiota dysbiosis in severe obesity: Fate after bariatric surgery. Gut. 2019;68:70–82. doi: 10.1136/gutjnl-2018-316103. PubMed DOI PMC
Zaura E, Nicu EA, Krom BP, Keijser BJF. Acquiring and maintaining a normal oral microbiome: Current perspective. Front. Cell. Infect. Microbiol. 2014;4:85. doi: 10.3389/fcimb.2014.00085. PubMed DOI PMC
Acharya A, et al. Salivary microbiome in non-oral disease: A summary of evidence and commentary. Arch. Oral Biol. 2017;83:169–173. doi: 10.1016/j.archoralbio.2017.07.019. PubMed DOI
Dagan SS, et al. Nutritional recommendations for adult bariatric surgery patients: Clinical practice. Adv. Nutr. 2017;8:382–394. doi: 10.3945/an.116.014258. PubMed DOI PMC
Klindworth A, et al. Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies. Nucleic Acids Res. 2013;41:e1. doi: 10.1093/nar/gks808. PubMed DOI PMC
Schloss PD, et al. Introducing mothur: Open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl. Environ. Microbiol. 2009;75:7537–7541. doi: 10.1128/AEM.01541-09. PubMed DOI PMC
Rognes T, Flouri T, Nichols B, Quince C, Mahé F. VSEARCH: A versatile open source tool for metagenomics. PeerJ. 2016;4:e2584. doi: 10.7717/peerj.2584. PubMed DOI PMC
Oksanen, J. et al. Vegan: Community Ecology Package. R Package Version 2.4. (2017).
Robinson MD, McCarthy DJ, Smyth GK. edgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139–140. doi: 10.1093/bioinformatics/btp616. PubMed DOI PMC
Harrell, F. E. Hmisc: Harrell Miscellaneous. R Package Version 4 (2019).
Wei, T. & Simko, V. Corrplot: Visualization of a Correlation Matrix. R Package Version 0.84 (2018).
Eklund, A. Beeswarm: The Bee Swarm Plot, an Alternative to Stripchart. R Package Version 0.2.3. (2016).