Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation: Data From the ESADA Cohort
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- atrial fibrillation, embolism, hypoxia, risk factor, sleep apnea,
- MeSH
- Databases, Factual MeSH
- Embolism epidemiology MeSH
- Atrial Fibrillation complications MeSH
- Risk Assessment MeSH
- Hypoxia complications MeSH
- Cohort Studies MeSH
- Oxygen blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Heart Diseases epidemiology MeSH
- Sleep Apnea, Obstructive complications epidemiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxygen MeSH
BACKGROUND AND PURPOSE: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. METHODS: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Spo2 and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA2DS2-VASc score. RESULTS: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA2DS2-VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Spo2 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P<0.05). CONCLUSIONS: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.
Department of Internal Medicine and Cardiology University Hospital Brno
Department of Medicine and Surgery University of Milan Bicocca Italy
IRCCS Istituto Auxologico Italiano Milan Italy
Sleep Disorders Center Reinbeck Germany
Sleep Disorders Center Respiratory Medicine Sahgrenska University Hospital Gothenburg Sweden
University Hospital L Pasteur Košice Univerzitná nemocnica L Pasteura Košice Slovakia
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