Mechanical thrombectomy is now well - established first - line treatment for selected patients with large artery occlusions of the anterior circulation. However, number of technical and procedural issues remains open to assure optimal outcomes in majority of patients including those suffering from posterior circulation perfusion defects. This brief review addresses some of the open issues and refers to the ongoing trials to close the existing knowledge gaps.

Cardiology Cardiocenter 3rd Faculty of Medicine Charles University University Hospital Kralovske Vinohrady Prague Czech Republic

Cardiology Postgraduate Medical School University of Hertfordshire Hatfield UK

Cardiovascular Medicine Mitteldeutsches Herzzentrum Standort Bitterfeld Klinikum Bitterfeld Wolfen Friedrich Ludwig Jahn Straße 2 D 06749 Bitterfeld Wolfen Germany

Department of Interventional Neuroradiology Department Fondation Ophtalmologique Adolphe de Rothschild Hospital Laboratory of Vascular Translational Science U1148 Institut National de la Santé et de la Recherche Médicale Paris University Paris France

Department of Medicine National Heart and Lung Institute Imperial College London UK

Department of Neuroradiology University Hopital Pierre Paul Riquet Toulouse France

Neurology Neurology Statename California Ronald Reagan UCLA Medical Center USA

Stroke Unit Lariboisière Hospital Paris France

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