The current study focused on longitudinal effects of genetics and parental behaviors and their interplay on externalizing behaviors in a panel study following individuals from adolescence to young adulthood. The nationally representative sample of Add Health participants of European ancestry included N = 4142 individuals, measured on three occasions. Parenting was operationalized as experiences with child maltreatment and maternal closeness. Externalizing problems were operationalized as alcohol use, cannabis use, and antisocial behaviors. Genetic effects were operationalized as a polygenic score (PGS) of risky behaviors. The results showed significant effects for child maltreatment, maternal closeness, and PGS, above and beyond other factors and previous levels of externalizing behaviors. Furthermore, maternal closeness was found to negatively correlate with PGS. No significant interaction effects of parenting and PGS were found. The results underscore the joint independent effects of parenting and genetics on the change in externalizing behaviors from adolescence to young adulthood.

Department of Family Sciences University of Kentucky 160 Funkhouser Dr Lexington KY 40506 0054 USA

Department of Psychology Virginia Commonwealth University Box 842018 Richmond VA 23284 2018 USA

Research Center for Toxic Compounds Masaryk University Kamenice 5 62500 Brno Czech Republic

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Auton A, Abecasis GR, Altshuler DM, et al. (2015) A global reference for human genetic variation. Nature 526:68–74. 10.1038/nature15393 PubMed DOI PMC

Avinun R, Knafo A (2014) Parenting as a reaction evoked by children’s genotype: A meta-analysis of children-as-twins studies. Pers Soc Psychol Rev Psychology Review 18:87–102 PubMed

Balbona JV, Kim Y, Keller MC (2021) Estimation of parental effects using polygenic scores. Behavior genetics 51:264–278. https://doi.org/10/gj99c3 PubMed PMC

Baumrind D (1991) The influence of parenting style on adolescent competence and substance use. J Early Adolescence 11:56–95. https://doi.org/10/b9z

Berkien M, Louwerse A, Verhulst F, van der Ende J (2012) Children’s perceptions of dissimilarity in parenting styles are associated with internalizing and externalizing behavior. Eur Child Adoles Psy 21:79–85. https://doi.org/10/fzzbz9 PubMed PMC

Braudt D, Harris KM (2020) Polygenic scores (PGSs) in the National Longitudinal Study of Adolescent to Adult Health (Add Health)–release 2

Brown SA, McGue M, Maggs J, et al. (2008) A developmental perspective on alcohol and youths 16 to 20 years of age. Pediatrics 121:S290–S310. 10.1542/peds.2007-2243D PubMed DOI PMC

Bulik-Sullivan BK, Loh P-R, Finucane HK, et al. (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature genetics 47:291–295. https://doi.org/10/f3t79j PubMed PMC

Burt SA, McGue M, Krueger RF, Iacono WG (2005) How are parent-child conflict and childhood externalizing symptoms related over time? Results from a genetically informative cross-lagged study. Dev Psychopathol 17:145–165. 10.1017/s095457940505008x PubMed DOI PMC

Carter A (2019) The consequences of adolescent delinquent behavior for adult employment outcomes. J Youth Adolescence 48:17–29. 10.1007/s10964-018-0934-2 PubMed DOI

Chen P, Jacobson KC (2012) Developmental trajectories of substance use from early adolescence to young adulthood: gender and racial/ethnic differences. J Adolesc Health 50:154–163. 10.1016/j.jadohealth.2011.05.013 PubMed DOI PMC

Cicchetti D, Handley ED (2019) Child maltreatment and the development of substance use and disorder. Neurobiology of Stress 10:100144. https://doi.org/10/gh2n9b PubMed PMC

Cicchetti D, Toth SL (2005) Child Maltreatment. Annu Rev Clin Psychol 1:409–438. 10.1146/annurev.clinpsy.1.102803.144029 PubMed DOI

Darling N, Steinberg L (1993) Parenting style as context: An integrative model. Psychol Bull 113:487–496. https://doi.org/10/bmm2f7

Deutsch AR, Crockett LJ, Wolff JM, Russell ST (2012) Parent and peer pathways to adolescent delinquency: Variations by ethnicity and neighborhood context. J Youth Adolescence 41:1078–1094. https://doi.org/10/f362ww PubMed

Dick D, Koellinger P, Harden P, et al. (2019) M66 USING THE GENETIC ARCHITECTURE OF EXTERNALIZING DISORDERS AND BEHAVIORS TO AID IN GENE IDENTIFICATION AND UNDERSTANDING PATHWAYS OF RISK. European Neuropsychopharmacology 29:S202. 10.1016/j.euroneuro.2019.08.166 DOI

Dick DM, Adkins AE, Kuo SI-C (2016) Genetic influences on adolescent behavior. Neurosci Biobeh R 70:198–205. 10.1016/j.neubiorev.2016.07.007 PubMed DOI PMC

Dick DM, Agrawal A (2008) The genetics of alcohol and other drug dependence. Alcohol Res Health 31:111–118 PubMed PMC

Dick DM, Agrawal A, Keller MC, et al. (2015) Candidate gene–environment interaction research: Reflections and recommendations. Perspect Psychol Sci 10:37–59. 10.1177/1745691614556682 PubMed DOI PMC

Dick DM, Aliev F, Wang JC, et al. (2008) Using dimensional models of externalizing psychopathology to aid in gene identification. Arch Gen Psychiat 65:310–318 PubMed

Dick DM, Barr PB, Cho SB, et al. (2018) Post-GWAS in psychiatric genetics: A developmental perspective on the “other” next steps. Genes Brain Behav 17:e12447–e12447. 10.1111/gbb.12447 PubMed DOI PMC

Dick DM, Viken R, Purcell S, et al. (2007) Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking. J Abnorm Psychol 116:213–218. https://doi.org/10/d6cbrb PubMed PMC

Dodge KA, Pettit GS, Bates JE (1994) Socialization mediators of the relation between socioeconomic status and child conduct problems. Child Dev 65:649–665. 10.1111/j.1467-8624.1994.tb00774.x PubMed DOI

Duncan L, Shen H, Gelaye B, et al. (2019) Analysis of polygenic risk score usage and performance in diverse human populations. Nature Commun 10:3328. 10.1038/s41467-019-11112-0 PubMed DOI PMC

Fletcher AC, Steinberg L, Williams-Wheeler M (2004) Parental influences on adolescent problem behavior: Revisiting Stattin and Kerr. Child Dev 75:781–796. 10.1111/j.1467-8624.2004.00706.x PubMed DOI

Foster EM, Jones DE (2005) The high costs of aggression: Public expenditures resulting from conduct disorder. Am J Public Health 95:1767–1772. 10.2105/AJPH.2004.061424 PubMed DOI PMC

Foster KT, Arterberry BJ, Iacono WG, et al. (2018) Psychosocial functioning among regular cannabis users with and without cannabis use disorder. Psychol Med 48:1853–1861. 10.1017/S0033291717003361 PubMed DOI PMC

Gault-Sherman M (2012) It’s a two-way street: The bidirectional relationship between parenting and delinquency. J Youth Adolescence 41:121–145. https://doi.org/10/fg5nfs PubMed

Ge T, Chen C-Y, Ni Y, et al. (2019) Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nature Commun 10:1776. 10.1038/s41467-019-09718-5 PubMed DOI PMC

Gottfredson MR, Hirschi T (1990) A general theory of crime. Stanford University Press, Stanford, CA

Harden KP, Kretsch N, Mann FD, et al. (2017) Beyond dual systems: A genetically-informed, latent factor model of behavioral and self-report measures related to adolescent risk-taking. Dev Cogn Neuros 25:221–234. 10.1016/j.dcn.2016.12.007 PubMed DOI PMC

Hicks BM, Foster KT, Iacono WG, McGue M (2013) Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. JAMA Psychiat 70:1076. https://doi.org/10/f5cwft PubMed PMC

Higgins DJ, McCabe MP (2001) Multiple forms of child abuse and neglect: adult retrospective reports. Aggress Violent Beh 6:547–578. 10.1016/S1359-1789(00)00030-6 DOI

Hoeve M, Dubas JS, Eichelsheim VI, et al. (2009) The relationship between parenting and delinquency: A meta-analysis. J Abnorm Child Psychol 37:749–775. https://doi.org/10/g6b PubMed PMC

Horwitz BN, Neiderhiser JM (2011) Gene - environment interplay, family relationships, and child adjustment. J Marriage Fam 73:804–816. 10.1111/j.1741-3737.2011.00846.x PubMed DOI PMC

Johnson EC, Tillman R, Aliev F, et al. (2019) Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement. Addiction 114:687–697. 10.1111/add.14512 PubMed DOI PMC

Keiley MK, Howe TR, Dodge KA, et al. (2001) The timing of child physical maltreatment: A cross-domain growth analysis of impact on adolescent externalizing and internalizing problems. Dev Psychopathol 13:891–912 PubMed PMC

Keller MC (2014) Gene-by-environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biol Psychiatry 75:. 10.1016/j.biopsych.2013.09.006 PubMed DOI PMC

Kendler KS, Baker JH (2007) Genetic influences on measures of the environment: a systematic review. Psychol Med 37:615–626. 10.1017/S0033291706009524 PubMed DOI

Kendler KS, Gardner C, Dick DM (2011) Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. Psychol Med 41:1507–1516. https://doi.org/10/bq8ssw PubMed PMC

Kendler KS, Myers J (2014) The boundaries of the internalizing and externalizing genetic spectra in men and women. Psychol Med 44:647–655. 10.1017/S0033291713000585 PubMed DOI PMC

Kendler KS, Neale MC, Sullivan P, et al. (1999) A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 29:299–308. 10.1017/s0033291798008022 PubMed DOI

Kim J, Cicchetti D (2009) Longitudinal pathways linking child maltreatment, emotion regulation, peer relations, and psychopathology: Pathways linking maltreatment, emotion regulation, and psychopathology. J Child Psychol Psyc 51:706–716. https://doi.org/10/cnbq3d PubMed PMC

Kong A, Thorleifsson G, Frigge ML, et al. (2018) The nature of nurture: Effects of parental genotypes. Science 359:424–428. https://doi.org/10/gf92jk PubMed

Korhonen T, Levälahti E, Dick DM, et al. (2010) Externalizing behaviors and cigarette smoking as predictors for use of illicit drugs: a longitudinal study among Finnish adolescent twins. Twin Res Hum Genet 13:550–558. 10.1375/twin.13.6.550 PubMed DOI PMC

Krueger RF, Hicks BM, Patrick CJ, et al. (2002) Etiologic connections among substance dependence, antisocial behavior and personality: Modeling the externalizing spectrum. J Abnorm Psychol 111:411–424. https://doi.org/10/cvp4dx PubMed

Lansford JE, Miller-Johnson S, Berlin LJ, et al. (2007) Early physical abuse and later violent delinquency: A prospective longitudinal study. Child Maltreat 12:233–245. 10.1177/1077559507301841 PubMed DOI PMC

Lawson DJ, Davies NM, Haworth S, et al. (2020) Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity? Human Genetics 139:23–41 PubMed PMC

Lee JJ, Wedow R, Okbay A, et al. (2018) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics 50:1112. https://doi.org/10/gdvmq2 PubMed PMC

Linnér RK, Biroli P, Kong E, et al. (2019) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet 51:245–257. 10.1038/s41588-018-0309-3 PubMed DOI PMC

Long EC, Verhulst B, Aggen SH, et al. (2017) Contributions of genes and environment to developmental change in alcohol use. Behav Genet 47:498–506. https://doi.org/10/gbvmzg PubMed

Lowe K, Dotterer AM (2013) Parental monitoring, parental warmth, and minority youths’ academic outcomes: Exploring the integrative model of parenting. J Youth Adolescence 42:1413–1425. 10.1007/s10964-013-9934-4 PubMed DOI

Luk JW, Worley MJ, Winiger E, et al. (2016) Risky driving and sexual behaviors as developmental outcomes of co-occurring substance use and antisocial behavior. Drug Alcohol Depen 169:19–25. https://doi.org/10/gh2n4j PubMed PMC

MacKenzie MJ, Nicklas E, Waldfogel J, Brooks-Gunn J (2012) Corporal punishment and child behavioural and cognitive outcomes through 5 years of age: Evidence from a contemporary urban birth cohort study. Infant and Child Dev 21:3–33. 10.1002/icd.758 PubMed DOI PMC

MacMillan HL, Fleming JE, Streiner DL, et al. (2001) Childhood abuse and lifetime psychopathology in a community sample. Am J Psychiat 158:1878–1883. https://doi.org/10/cqqhmb PubMed

Martin AR, Gignoux CR, Walters RK, et al. (2017) Human demographic history impacts genetic risk prediction across diverse populations. Am J Hum Genet 100:635–649. 10.1016/j.ajhg.2017.03.004 PubMed DOI PMC

Martin AR, Kanai M, Kamatani Y, et al. (2019) Clinical use of current polygenic risk scores may exacerbate health disparities. Nat Genet 51:584–591. 10.1038/s41588-019-0379-x PubMed DOI PMC

McCarthy S, Das S, Kretzschmar W, et al. (2016) A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet 48:1279–1283. 10.1038/ng.3643 PubMed DOI PMC

McKee L, Colletti C, Rakow A, et al. (2008) Parenting and child externalizing behaviors: Are the associations specific or diffuse? Aggress Violent Beh 13:201–215. https://doi.org/10/brffqb PubMed PMC

Morris AS, Criss MM, Silk JS, Houltberg BJ (2017) The impact of parenting on emotion regulation during childhood and adolescence. Child Dev Perspectives 11:233–238. https://doi.org/10/gckwcv

Morris AS, Silk JS, Steinberg L, et al. (2007) The role of the family context in the development of emotion regulation. Soc Dev 16:361–388. https://doi.org/10/cjmr96 PubMed PMC

Muthén LK, Muthén BO (1998-2017) Mplus User’s Guide. Eighth Edition. Muthén and Muthén, Los Angeles, CA

Pezzoli P, Antfolk J, Hatoum AS, Santtila P (2019) Genetic vulnerability to experiencing child maltreatment. Front Genet 10:. https://doi.org/10/gkdbk8 PubMed PMC

Pinquart M (2017) Associations of parenting dimensions and styles with externalizing problems of children and adolescents: An updated meta-analysis. Dev Psychol 53:873–932. https://doi.org/10/f96xcd PubMed

Powell D, Perreira KM, Mullan Harris K (2010) Trajectories of delinquency from adolescence to adulthood. Youth Soc 41:475–502. 10.1177/0044118X09338503 DOI

Salvatore JE, Aliev F, Bucholz K, et al. (2015) Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. Clin Psychol Sci 3:189–201. 10.1177/2167702614534211 PubMed DOI PMC

Samek DR, Hicks BM, Keyes MA, et al. (2015) Gene-environment interplay between parent-child relationship problems and externalizing disorders in adolescence and young adulthood. Psychol Med 45:333–344. 10.1017/S0033291714001445 PubMed DOI PMC

Scarr S, McCartney K (1983) How people make their own environments: A theory of genotype → environment effects. Child Dev 54:424–435. https://doi.org/10/c73s43 PubMed

Schulenberg J, Wadsworth KN, O’Malley PM, et al. (1996) Adolescent risk factors for binge drinking during the transition to young adulthood: Variable- and pattern-centered approaches to change. Dev Psychol 32:659–674. 10.1037/0012-1649.32.4.659 DOI

Shanahan MJ, Boardman JD (2009) Genetics and Behavior in the Life Course. In: Elder GH, Giele JZ (eds) The Craft of Life Course Research. The Guilford Press, New York, NY, p 21

Sher KJ, Rutledge PC (2007) Heavy drinking across the transition to college: Predicting first-semester heavy drinking from precollege variables. Addict Behav 32:819–835. 10.1016/j.addbeh.2006.06.024 PubMed DOI PMC

Smith C, Thornberry TP (1995) The relationship between childhood maltreatment and adolescent involvement in delinquency. Criminology 33:451–481. 10.1111/j.1745-9125.1995.tb01186.x DOI

Smith CA, Ireland TO, Thornberry TP, Elwyn L (2008) Childhood maltreatment and antisocial behavior: Comparison of self-reported and substantiated maltreatment. Am J Orthopsychiat 78:173–186. https://doi.org/10/cxkh2n PubMed

Steinberg L (2001) We know some things: Parent–adolescent relationships in retrospect and prospect. J Res Adol 11:1–19. 10.1111/1532-7795.00001 DOI

Steinberg L, Blatt-Eisengart I, Cauffman E (2006) Patterns of competence and adjustment among adolescents from authoritative, authoritarian, indulgent, and neglectful homes: A Replication in a sample of serious juvenile offenders. J Res Adolesc 16:47–58. 10.1111/j.1532-7795.2006.00119.x PubMed DOI PMC

Steinberg L, Lamborn SD, Darling N, et al. (1994) Over-time changes in adjustment and competence among adolescents from authoritative, authoritarian, indulgent, and neglectful families. Child Dev 65:754–770. 10.2307/1131416 PubMed DOI

Steinberg L, Morris AS (2001) Adolescent development. Annu Rev of Psychol 52:83–110. 10.1146/annurev.psych.52.1.83 PubMed DOI

Su J, Kuo SI-C, Bucholz KK, et al. (2018) Understanding mechanisms of genetic risk for adolescent internalizing and externalizing problems: The mediating role of parenting and personality. Twin Res and Hum Genet 21:310–321. 10.1017/thg.2018.36 PubMed DOI

Thornberry TP, Krohn MD (2000) The self-report method for measuring delinquency and crime. In Criminal justice 4:33–83

Tung I, Noroña AN, Lee SS (2019) Childhood maltreatment affects adolescent sensitivity to parenting and close friendships in predicting growth in externalizing behavior. Dev Psychopathol 31:1237–1253. 10.1017/S0954579418000585 PubMed DOI

Verweij KJH, Zietsch BP, Lynskey MT, et al. (2010) Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. Addiction 105:417–430. 10.1111/j.1360-0443.2009.02831.x PubMed DOI PMC

Vieno A, Nation M, Pastore M, Santinello M (2009) Parenting and antisocial behavior: a model of the relationship between adolescent self-disclosure, parental closeness, parental control, and adolescent antisocial behavior. Dev Psychol 45:1509–1519. 10.1037/a0016929 PubMed DOI