Systematic study of paracetamol powder mixtures and granules tabletability: Key role of rheological properties and dynamic image analysis
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
34547394
DOI
10.1016/j.ijpharm.2021.121110
PII: S0378-5173(21)00916-9
Knihovny.cz E-zdroje
- Klíčová slova
- Dynamic image analysis, Heckel analysis, High shear granulation, Paracetamol, Powder rheology, Tabletability,
- MeSH
- paracetamol * MeSH
- pevnost v tahu MeSH
- prášky, zásypy, pudry MeSH
- příprava léků MeSH
- reologie MeSH
- tablety MeSH
- velikost částic MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- paracetamol * MeSH
- prášky, zásypy, pudry MeSH
- tablety MeSH
The aim of this systematic study was to analyze the granulometric and rheological behavior of tableting mixtures in relation to tabletability by single tablet and lab-scale batch compression with an eccentric tablet machine. Three mixtures containing 33, 50, and 66% of the cohesive drug paracetamol were prepared. The high compressibility of the powder mixtures caused problems with overcompaction or lamination in the single tablet compression method; due to jamming of the material during the filling of the die, the lab-scale batch compression was impossible. Using high shear granulation, the flow properties and tabletability were adjusted. A linear relationship between the span of granules and the specific energy measured by FT4 powder rheometer was detected. In parallel, a linear relationship between conditioned bulk density and the tensile strength of the tablets at lab-scale batch tableting was noted. The combination of dynamic image analysis and powder rheometry was useful for predicting the tabletability of pharmaceutical mixtures during the single tablet (design) compression and the lab-scale batch compression.
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