Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.

BIOARABA Department of Neuroscience UPV EHU CIBERSAM Vitoria Spain

Charité Universitätsmedizin Berlin Department of Child and Adolescent Psychiatry Berlin Germany; Donald and Barbara Zucker School of Medicine at Hofstra Northwell Department of Psychiatry and Molecular Medicine Hempstead NY USA; The Zucker Hillside Hospital Department of Psychiatry Northwell Health Glen Oaks NY USA

Copenhagen Affective Disorder research Center Psychiatric Center Copenhagen Copenhagen Denmark; Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Dalhousie University Department of Psychiatry Canada National Institute of Mental Health Klecany Czech Republic; National Institute of Mental Health Klecany Czech Republic

Departement of Psychiatry Service Hospitalo Universitaire GHU Paris Psychiatrie and Neurosciences Paris France Université de Paris Paris France

Department for Psychiatry Psychotherapy and Psychosomatic Vivantes Hospital am Urban and Friedrichshain; Charité Universitätsmedizin Berlin Germany

Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health University Heidelberg Medical Faculty Mannheim Mannheim Germany

Department of Psychiatry Aalborg University Hospital Aalborg Denmark; Department of Clinical Medicine Aalborg University Aalborg Denmark

Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology University of Gothenburg Gothenburg Sweden; Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

Department of Psychiatry and Psychotherapy Carl Gustav Carus University Hospital Dresden Technische Universität Dresden Dresden Germany

Department of Psychiatry Icahn School of Medicine at Mount Sinai New York USA; Department of Psychiatry Erasmus Medical Center Rotterdam the Netherlands

Department of Psychiatry Psychosomatic Medicine and Psychotherapy; University Hospital Frankfurt Frankfurt am Main Germany

Department of Psychiatry University of Oxford Oxford United Kingdom

Dept of Psychiatry Amsterdam University Medical Centers Vrije Universiteit Amsterdam Netherlands

Dokuz Eylul University Izmir Turkey Department of Psychiatry

Institute of Neuroscience Hospital Clinic University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain

Institute of Neuroscience Newcastle University Newcastle UK

Laboratory of Pharmacogenomics Department of Biomedical Sciences University of Cagliari Cagliari Italy

LMU University Hospital Institute of Psychiatric Phenomics and Genomics Ludwig Maximilians University of Munich Germany

Medical University Graz Department of Psychiatry and Psychotherapeutic Medicine

Medical University Graz Klinische Abteilung für Rheumatologie und Immunologie

NORMENT Centre Division of Mental Health and Addiction Oslo University Hospital Oslo Norway

NORMENT Centre Division of Mental Health and Addiction Oslo University Hospital Oslo Norway; NORMENT Centre Institute of Clinical Medicine University of Oslo Oslo Norway

Osakidetza Basque Health Service Health Service BioAraba Research Institute University of the Basque Country Vitoria Spain; The Psychology Clinic of East Anglia Norwich England

St Olav University Hospital and Norwegian University of Science and Technology NTNU Faculty of Medicine and Health Sciences

Unit of Psychiatry Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy; Unit of Clinical Psychiatry University Hospital Agency of Cagliari Cagliari Italy; Department of Pharmacology Dalhousie University Halifax NS Canada

Universita di Siena Molecular Medicine

Universite de Paris INSERM UMRS 1144 DMU Neurosciences GHU Lariboisière Fernand Widal Departement de Psychiatrie APHP Paris France

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