Spatio-temporal spike dynamics predict surgical outcome in adult focal epilepsy
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
PJT-175056
CIHR - Canada
PubMed
34991017
DOI
10.1016/j.clinph.2021.10.023
PII: S1388-2457(21)00877-4
Knihovny.cz E-zdroje
- Klíčová slova
- Intracranial EEG, Spike dynamics, Surgical outcomes,
- MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- epilepsie parciální patofyziologie chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mapování mozku MeSH
- mladý dospělý MeSH
- modely neurologické MeSH
- mozek patofyziologie chirurgie MeSH
- mozkové vlny fyziologie MeSH
- neurochirurgické výkony MeSH
- prognóza MeSH
- refrakterní epilepsie patofyziologie chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: We hypothesized that spatio-temporal dynamics of interictal spikes reflect the extent and stability of epileptic sources and determine surgical outcome. METHODS: We studied 30 consecutive patients (14 good outcome). Spikes were detected in prolonged stereo-electroencephalography recordings. We quantified the spatio-temporal dynamics of spikes using the variance of the spike rate, line length and skewness of the spike distribution, and related these features to outcome. We built a logistic regression model, and compared its performance to traditional markers. RESULTS: Good outcome patients had more dominant and stable sources than poor outcome patients as expressed by a higher variance of spike rates, a lower variance of line length, and a lower variance of positive skewness (ps < 0.05). The outcome was correctly predicted in 80% of patients. This was better or non-inferior to predictions based on a focal lesion (p = 0.016), focal seizure-onset zone, or complete resection (ps > 0.05). In the five patients where traditional markers failed, spike distribution predicted the outcome correctly. The best results were achieved by 18-h periods or longer. CONCLUSIONS: Analysis of spike dynamics shows that surgery outcome depends on strong, single and stable sources. SIGNIFICANCE: Our quantitative method has the potential to be a reliable predictor of surgical outcome.
Citace poskytuje Crossref.org
