Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

Center for Mind Brain and Behavior University of Marburg Marburg Germany

Centre for Human Genetics University of Marburg Marburg Germany

Centro de Investigación Biomedica en Red de Salud Mental Barcelona Spain

Department of Biomedical Sciences University of Cagliari Cagliari Italy

Department of Genetic Epidemiology in Psychiatry Medical Faculty Mannheim Central Institute of Mental Health Heidelberg University Mannheim Germany

Department of Immunology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of Neurology Klinikum Rechts Der Isar School of Medicine Technical University of Munich Munich Germany

Department of Psychiatric Genetics Poznan University of Medical Sciences Poznan Poland

Department of Psychiatry and Behavioral Science Juntendo University Graduate School of Medicine Tokyo Japan

Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore MD USA

Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University Syracuse NY USA

Department of Psychiatry and Psychotherapy University Hospital Munich Munich Germany

Department of Psychiatry and Psychotherapy University of Marburg Marburg Germany

Department of Psychiatry Dalhousie University Halifax Canada

Department of Psychiatry Geneva University Hospitals Geneva Switzerland

Department of Psychiatry University of California San Diego La Jolla CA USA

Department of Psychiatry University of Toronto Toronto ON Canada

Faculty of Medicine University of Geneva Geneva Switzerland

Global Computational Biology and Data Sciences Boehringer Ingelheim Pharma GmbH and Co KG 88397 Biberach an der Riß Germany

Institute for Translational Neuroscience University of Münster Munster Germany

Institute for Translational Psychiatry University of Munster Munster Germany

Institute of Human Genetics School of Medicine and University of Bonn University Hospital Bonn Bonn Germany

Institute of Neuroscience and Medicine Research Centre Jülich Jülich Germany

Institute of Psychiatric Phenomics and Genomics University Hospital LMU Munich Nussbaumstr 7 80336 Munich Germany

International Max Planck Research School for Translational Psychiatry Munich Germany

Montreal Neurological Institute McGill University Montreal Canada

Mood Disorders Clinic of Ottawa Ottawa ON Canada

National Center for Global Health and Medicine Tokyo Japan

National Institute of Mental Health Klecany Czech Republic

Psychiatric Genetics Research Unit Alexandru Obregia Clinical Psychiatric Hospital Bucharest Romania

Rd Faculty of Medicine Charles University Prague Czech Republic

The Douglas Research Centre McGill University Montreal Canada

Unit of Clinical Pharmacology University Hospital Agency of Cagliari Cagliari Italy

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