Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
CZ.02.1.01/0.0/0.0/16_019/0000766
European Regional Development Fund-Project, "Engineering applications of microworld physics"
No. TL03000207
Technology Agency of the Czech Republic
SGS21/177/OHK4/3T/17
Grant Agency of the Czech Technical University in Prague
No. FV30311, Contract ID 2018FV30311
Technology Agency of the Czech Republic
TA 29
Funds of institutional research (TA 29) FVM UVS Brno
TRIO FV30311
MPO ČR
PubMed
35323271
PubMed Central
PMC8949947
DOI
10.3390/gels8030158
PII: gels8030158
Knihovny.cz E-zdroje
- Klíčová slova
- dead space, drug delivery system, fractionalized nanofibers, gel rigidification,
- Publikační typ
- časopisecké články MeSH
Dead space after rectal resection in colorectal surgery is an area with a high risk of complications. In this study, our goal was to develop a novel 3D implant based on composite hydrogels enriched with fractionalized nanofibers. We employed, as a novel approach in abdominal surgery, the application of agarose gels functionalized with fractionalized nanofibers on pieces dozens of microns large with a well-preserved nano-substructure. This retained excellent cell accommodation and proliferation, while nanofiber structures in separated islets allowed cells a free migration throughout the gel. We found these low-concentrated fractionalized nanofibers to be a good tool for structural and biomechanical optimization of the 3D hydrogel implants. In addition, this nano-structuralized system can serve as a convenient drug delivery system for a controlled release of encapsulated bioactive substances from the nanofiber core. Thus, we present novel 3D nanofiber-based gels for controlled release, with a possibility to modify both their biomechanical properties and drug release intended for 3D lesions healing after a rectal extirpation, hysterectomy, or pelvic exenteration.
2nd Faculty of Medicine Charles University 15000 Prague Czech Republic
Ambis College Lindnerova 575 1 18000 Prague Czech Republic
Department of Biomedical Sciences University of Sassari 07100 Sassari Italy
Faculty of Biomedical Engineering Czech Technical University Prague 27201 Prague Czech Republic
Faculty of Physical Education and Sport Charles University 16252 Prague Czech Republic
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