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1st Department of Internal Medicine F... 1 2nd Faculty of Medicine Charles Unive... 1 Ambis College Lindnerova 575 1 18000 ... 1 Department of Anaesthesiology and Int... 1 Department of Biomedical Sciences Uni... 1 Faculty of Biomedical Engineering Cze... 1 Faculty of Physical Education and Spo... 1 Faculty of Veterinary Medicine Univer... 1 Student Science 19012 Prague Czech Re... 1 University Centre for Energy Efficien... 1
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1st Department of Internal Medicine F... 1 2nd Faculty of Medicine Charles Unive... 1 Ambis College Lindnerova 575 1 18000 ... 1 Department of Anaesthesiology and Int... 1 Department of Biomedical Sciences Uni... 1 Faculty of Biomedical Engineering Cze... 1 Faculty of Physical Education and Spo... 1 Faculty of Veterinary Medicine Univer... 1 Student Science 19012 Prague Czech Re... 1 University Centre for Energy Efficien... 1
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- Bocková, Markéta
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Pashchenko, Aleksei
Autor Pashchenko, Aleksei ORCID Second Faculty of Medicine, Charles University, 15000 Prague, Czech Republic University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 27343 Bustehrad, Czech Republic Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
- Stuchlíková, Simona
- Kalábová, Hana
- Divín, Radek
- Novotný, Petr
- Kestlerová, Andrea
- Jelen, Karel
- Kubový, Petr
- Firment, Peter, 1982-
PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2015-09-01
Open Access Digital Library od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources od 2015
PubMed
35323271
DOI
10.3390/gels8030158
Knihovny.cz E-zdroje
Dead space after rectal resection in colorectal surgery is an area with a high risk of complications. In this study, our goal was to develop a novel 3D implant based on composite hydrogels enriched with fractionalized nanofibers. We employed, as a novel approach in abdominal surgery, the application of agarose gels functionalized with fractionalized nanofibers on pieces dozens of microns large with a well-preserved nano-substructure. This retained excellent cell accommodation and proliferation, while nanofiber structures in separated islets allowed cells a free migration throughout the gel. We found these low-concentrated fractionalized nanofibers to be a good tool for structural and biomechanical optimization of the 3D hydrogel implants. In addition, this nano-structuralized system can serve as a convenient drug delivery system for a controlled release of encapsulated bioactive substances from the nanofiber core. Thus, we present novel 3D nanofiber-based gels for controlled release, with a possibility to modify both their biomechanical properties and drug release intended for 3D lesions healing after a rectal extirpation, hysterectomy, or pelvic exenteration.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.