New screen-printed sensor with a boron-doped diamond working electrode (SP/BDDE) was fabricated using a large-area linear antenna microwave chemical deposition vapor system (LA-MWCVD) with a novel precursor composition. It combines the advantages of disposable printed sensors, such as tailored design, low cost, and easy mass production, with excellent electrochemical properties of BDDE, including a wide available potential window, low background currents, chemical resistance, and resistance to passivation. The newly prepared SP/BDDEs were characterized by scanning electron microscopy (SEM) and Raman spectroscopy. Their electrochemical properties were investigated by cyclic voltammetry and electrochemical impedance spectroscopy using inner sphere ([Fe(CN)6]4-/3-) and outer sphere ([Ru(NH3)6]2+/3+) redox probes. Moreover, the applicability of these new sensors was verified by analysis of the anti-inflammatory drug lornoxicam in model and pharmaceutical samples. Using optimized differential pulse voltammetry in Britton-Robinson buffer of pH 3, detection limits for lornoxicam were 9 × 10-8 mol L-1. The oxidation mechanism of lornoxicam was investigated using bulk electrolysis and online electrochemical cell with mass spectrometry; nine distinct reaction steps and corresponding products and intermediates were identified.

Department of Analytical Chemistry Faculty of Science Palacký University in Olomouc 17 listopadu 1192 12 779 00 Olomouc Czech Republic

Department of Graphic Arts Technology and Applied Photochemistry Faculty of Chemical and Food Technology Slovak University of Technology in Bratislava Radlinského 9 812 37 Bratislava Slovakia

Department of Organic Chemistry Faculty of Science Palacký University in Olomouc 17 listopadu 1192 12 779 00 Olomouc Czech Republic

Institute of Electronics and Photonics Faculty of Electrical Engineering and Information Technology Slovak University of Technology in Bratislava Ilkovičova 3 812 19 Bratislava Slovakia

Institute of Environmental and Chemical Engineering Faculty of Chemical Technology University of Pardubice Studentská 573 532 10 Pardubice Czech Republic

J Heyrovsky Institute of Physical Chemistry of the Academy of Sciences of the Czech Republic Dolejškova 3 182 23 Prague Czech Republic

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Effect of different modification by gold nanoparticles on the electrochemical performance of screen-printed sensors with boron-doped diamond electrode