Electro-Modulation of Tubulin Properties and Function
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- Atomic force microscopy, Dynamic light scattering, Fluorescence intensity, Microtubules, Nanosecond pulsed electric field, Self-assembly, Tubulin, Zeta potential,
- MeSH
- elektřina MeSH
- kvarterní struktura proteinů MeSH
- mikrotubuly * metabolismus MeSH
- tubulin * metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- tubulin * MeSH
Microtubules composed of tubulin heterodimers represent highly dynamic structures. These structures are essential for basic cellular functions, such as cell division. Microtubules can grow or shrink in response to environmental signals, principally chemical cues. Here, we provide an alternative-physical-strategy to modulate tubulin properties and its self-assembly process. The conformation and electrical properties of tubulin subunits are modulated by nanosecond electropulse signals. The formed structures of electrically treated tubulin are tightly linked to the degree of conformational and electrical properties changes induced by nanosecond electropulses. This strategy opens a new way for controlling the self-assembly process in biomolecules as well as in bioinspired materials.
Zobrazit více v PubMed
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