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Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

M. Vokurka, L. Lacina, J. Brábek, M. Kolář, YZ. Ng, K. Smetana

. 2022 ; 23 (2) : . [pub] 20220116

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc22011313

Grant support
project No. 19-05048S Grant Agency of the Czech Republic,
Research of the Cancer Microenvironment Supporting Cancer Growth and Spread", No. CZ.02.1.01/0.0/0.0/16_019/0000785 Ministry of Education, Youth and Sports of the Czech Republic
PROGRES Q28 Charles University

Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.

References provided by Crossref.org

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