Buckminsterfullerene (C60) has a large potential for biomedical applications. However, the main challenge for the realization of its biomedical application potential is to overcome its extremely low water solubility. One approach is the coformulation with biocompatible water-soluble polymers, such as poly(2-oxazoline)s (PAOx), to form water-soluble C60 nanoparticles (NPs). However, uniform and defined NPs have only been obtained via a thin film hydration method or using cyclodextrin-functionalized PAOx. Here, we report the mechanochemical preparation of defined and stable C60:PAOx NPs by the introduction of a simple alkyne group as a polymer end-group. The presence of this alkyne bond is proven to be crucial in the mechanochemical synthesis of stable, defined sub-100 nm C60:PAOx NPs, with high C60 content up to 8.9 wt %.

Department of Chemistry University of Oslo P O Box 1033 Blindern 0371 Oslo Norway

Ghent University Department of Biomedical Molecular Biology 9052 Ghent Belgium and VIB Center for Inflammation Research 9052 Ghent Belgium

Ghent University Expertise Centre for Transmission Electron Microscopy and VIB BioImaging Core 9052 Ghent Belgium

Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovského nám 2 162 06 Prague 6 Czech Republic

Supramolecular Chemistry Group Centre of Macromolecular Chemistry Department of Organic and Macromolecular Chemistry Ghent University Krijgslaan 281 S4 9000 Ghent Belgium

Citace poskytuje Crossref.org