Stability of a half-sandwich Os(II) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A
Language English Country Great Britain, England Media electronic
Document type Journal Article
PubMed
35670076
DOI
10.1039/d2dt01085b
Knihovny.cz E-resources
- MeSH
- Indomethacin pharmacology MeSH
- Carboxypeptidases A MeSH
- Coordination Complexes * chemistry pharmacology MeSH
- Ligands MeSH
- Cell Line, Tumor MeSH
- Antineoplastic Agents * chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Indomethacin MeSH
- Carboxypeptidases A MeSH
- Coordination Complexes * MeSH
- Ligands MeSH
- Antineoplastic Agents * MeSH
In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η6-pcym)(L2)Cl]PF6 (2) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2. Stability in the presence of other relevant biomolecules (GSH, NADH, GMP) and cancer cell viability were also studied.
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