Lesniowski-Crohn's disease (CD) is a type of chronic inflammatory bowel disease (IBD) of uncertain etiology. Initially, pharmacological management is undertaken; however, surgical intervention is necessary to improve life quality and relieve symptoms in most cases. Here changes are reported in blood metabolome that occurred three days after the ileo-colic region resection in the case of seven patients. Alterations are observed in levels of metabolites associated with multiple mitochondrial pathways, based on the Metabolite Set Enrichment Analysis, reflecting a high energy demand in the post-operative period. As most of these metabolites are also essential nutrients supplied from foods, we believe that our results might contribute to the discussion on perioperative nutrition's role in enhanced recovery.

Department of Analytical Chemistry Faculty of Chemical Technology University of Pardubice Studentská 573 CZ 532 10 Pardubice Czech Republic

Department of Biochemistry and Clinical Chemistry Faculty of Pharmacy Medical University of Warsaw Stefana Banacha 1 02 097 Warsaw Poland

Department of Bromatology Faculty of Pharmacy Medical University of Warsaw Stefana Banacha 1 02 097 Warsaw Poland

Department of Chemistry Institute of General and Ecological Chemistry Lodz University of Technology Stefana Żeromskiego 116 90 924 Lodz Poland

Department of General Oncological and Digestive Tract Surgery Medical Centre of Postgraduate Education Orłowski Hospital 00 416 Warsaw Poland

Institute of Bioorganic Chemistry Polish Academy of Sciences Zygmunta Noskowskiego 12 14 61 704 Poznan Poland

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