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Genetic mechanism for the loss of PRAME in B cell lymphomas

. 2022 Jul 15 ; 132 (14) : .

Language English Country United States Media print

Document type Letter, Comment

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Takata K, et al. Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma. J Clin Invest. 2022;132(10):e145343. doi: 10.1172/JCI145343. PubMed DOI PMC

Bouska A, et al. Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets. Blood. 2017;30(16):1819–1831. PubMed PMC

Gunn SR, et al. Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene. Leuk Res. 2009;33(9):1276–1281. doi: 10.1016/j.leukres.2008.10.010. PubMed DOI

Mraz M, et al. The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus. Leuk Res. 2013;37(7):802–808. doi: 10.1016/j.leukres.2013.03.018. PubMed DOI

Stamatopoulos B, et al. The light chain IgLV3-21 defines a new poor prognostic subgroup in chronic lymphocytic leukemia: results of a Multicenter Study. Clin Cancer Res. 2018;24(20):5048–5057. doi: 10.1158/1078-0432.CCR-18-0133. PubMed DOI

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