The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23608880
DOI
10.1016/j.leukres.2013.03.018
PII: S0145-2126(13)00105-7
Knihovny.cz E-resources
- MeSH
- Antigens, Neoplasm genetics MeSH
- Chromosome Deletion * MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell genetics MeSH
- Adult MeSH
- Gene Rearrangement * MeSH
- In Situ Hybridization, Fluorescence MeSH
- Immunoglobulin lambda-Chains genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 22 genetics MeSH
- Follow-Up Studies MeSH
- Polymerase Chain Reaction MeSH
- Prognosis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Comparative Genomic Hybridization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Neoplasm MeSH
- Immunoglobulin lambda-Chains MeSH
- PRAME protein, human MeSH Browser
The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q11 deletions are a consequence of the rearrangement of immunoglobulin lambda light chain locus (IGL) segments surrounding several protein-coding genes located in this region. Indeed, using array-CGH and PCR analysis we show that all deletions (n=7) affecting the 22q11 locus in our cohort (n=40) are based on the physiological mechanism of IGL rearrangement. This demonstrates that this loss of genetic material is likely not pathogenic and in fact is merely a marker of IGL rearrangement.
References provided by Crossref.org
Genetic mechanism for the loss of PRAME in B cell lymphomas
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