Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic-ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies. However, heterogeneity and subsequent lack of reproducibility of such models across laboratories is an ongoing challenge to maintain scientific rigor and knowledge advancement. To address this, as part of the TASK3-WG1B Working Group of the International League Against Epilepsy/American Epilepsy Society Joint Translational Task Force, we have developed a series of case report forms (CRFs) to describe common data elements for pediatric acquired epilepsy models in rodents. The "Rodent Models of Pediatric Acquired Epilepsy" Core CRF was designed to capture cohort-general information; while two Specific CRFs encompass physical induction models and chemical induction models, respectively. This companion manuscript describes the key elements of these models and why they are important to be considered and reported consistently. Together, these CRFs provide investigators with the tools to systematically record critical information regarding their chosen model of acquired epilepsy during early life, for improved standardization and transparency across laboratories. These outcomes will support the ultimate goal of such research; that is, to understand the childhood onset-specific biology of epileptogenesis after acquired insults, and translate this knowledge into therapeutics to improve pediatric patient outcomes and minimize the lifetime burden of epilepsy.

Department of Medicine The University of Melbourne Parkville Victoria Australia

Department of Neurology Alfred Health Prahran Victoria Australia

Department of Neuroscience Monash University Melbourne Victoria Australia

Department of Pharmacy School of Pharmacy University of Washington Seattle Washington USA

Epilepsy Research Centre Department of Medicine University of Melbourne Austin Health Heidelberg Victoria Australia

Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria Australia

Inserm LabEx ICST Institute of Molecular and Cellular Pharmacology CNRS UMR7275 Université Côte d'Azur Valbonne Sophia Antipolis France

Institut Universitaire de France Paris France

Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic

Isabelle Rapin Division of Child Neurology Laboratory of Developmental Epilepsy Dominick P Purpura Department of Neuroscience Albert Einstein College of Medicine Bronx New York USA

Laboratory of Developmental Epilepsy Saul R Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA

Service de Neurologie Pédiatrique Hôpital Robert Debré INSERM UMR 1141 APHP Université de Paris Paris France

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