Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost-effectiveness and scientific rigor of the studies performed. Here, we present two case report forms (CRFs) describing common data elements (CDE) for genetic rodent models, developed by the TASK3-WG1B Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force. The first CRF relates to genetic rodent models that have been engineered based on variants described in epilepsy patients. The second CRF encompasses both spontaneous and inbred rodent models. This companion piece describes the elements and discusses the important factors to consider before documenting each required element. These CRFs provide tools that allow investigators to more uniformly describe core experimental data on different genetic models across laboratories, with the aim of improving experimental reproducibility and thus translational impact of such studies.

Department of Medicine Epilepsy Research Centre University of Melbourne Austin Health Heidelberg Victoria Australia

Department of Medicine The University of Melbourne Parkville Victoria Australia

Department of Neurology Alfred Health Prahran Victoria Australia

Department of Neuroscience Monash University Prahran Victoria Australia

Department of Pharmacy School of Pharmacy University of Washington Seattle Washington USA

Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Victoria Australia

Institut Universitaire de France Paris France

Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic

Laboratory of Developmental Epilepsy Isabelle Rapin Division of Child Neurology Saul R Korey Department of Neurology Dominique P Purpura Department of Neuroscience Albert Einstein College of Medicine Bronx New York USA

Laboratory of Developmental Epilepsy Saul R Korey Department of Neurology Albert Einstein College of Medicine Bronx New York USA

Université Côte d'Azur CNRS UMR7275 Inserm LabEx ICST Institute of Molecular and Cellular Pharmacology Valbonne Sophia Antipolis France

Université de Paris INSERM UMR 1141 Service de Neurologie Pédiatrique Hôpital Robert Debré APHP Paris France

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