Estradiol and progesterone-induced lordosis behavior is modulated by both the Kisspeptin receptor and melanin-concentrating hormone in estradiol benzoate-primed rats
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
36115135
DOI
10.1016/j.yhbeh.2022.105257
PII: S0018-506X(22)00151-9
Knihovny.cz E-zdroje
- Klíčová slova
- Estradiol, Kisspeptin, Lordosis, Melanin-concentrating hormone, Progesterone,
- MeSH
- estradiol farmakologie MeSH
- hormon uvolňující gonadotropiny farmakologie MeSH
- kisspeptiny farmakologie MeSH
- krysa rodu Rattus MeSH
- lordóza * chemicky indukované MeSH
- ovarektomie MeSH
- progesteron * farmakologie MeSH
- sexuální chování zvířat fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- estradiol 3-benzoate MeSH Prohlížeč
- estradiol MeSH
- hormon uvolňující gonadotropiny MeSH
- kisspeptiny MeSH
- melanin-concentrating hormone MeSH Prohlížeč
- progesteron * MeSH
Intracerebroventricular (ICV) administration of estradiol benzoate (E2B) and progesterone (P) induces intense lordosis behavior in ovariectomized rats primed peripherally with E2B. The present study tested the hypothesis that the Kisspeptin (Kiss) and melanin-concentrating hormone (MCH) pathways regulate female sexual behavior induced by these steroid hormones. In Experiment 1, we tested the relevance of the Kiss pathway by ICV infusion of its inhibitor, kiss-234, before administration of E2B or P in estrogen-primed rats. Lordosis induced by E2B alone or with the addition of P was reduced significantly at 30, 120, and 240 min. In Experiment 2, ICV infusion of MCH 30 min before E2B or P significantly reduced lordosis in rats primed with E2B alone. These data support the hypothesis that the Kiss and MCH pathways, which can release or modulate gonadotropin-releasing hormone (GnRH), are involved in E2B- and P-induced lordosis.
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