BACKGROUND: The simple scoring systems for predicting the outcome of sepsis in intensive care units (ICUs) are few, especially for limited-resource settings. Therefore, this study aimed to evaluate the accuracy of the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score in predicting the mortality of ICU patients with sepsis in Vietnam. METHODS: We did a multicenter cross-sectional study of patients with sepsis (≥18 years old) presenting to 15 adult ICUs throughout Vietnam on the specified days (i.e., 9th January, 3rd April, 3rd July, and 9th October) representing the different seasons of 2019. The primary and secondary outcomes were the hospital and ICU all-cause mortalities, respectively. The area under the receiver operating characteristic curve (AUROC) was calculated to determine the discriminatory ability of the qSOFA score for deaths in the hospital and ICU. The cut-off value of the qSOFA scores was determined by the receiver operating characteristic curve analysis. Upon ICU admission, factors associated with the hospital and ICU mortalities were assessed in univariable and multivariable logistic models. RESULTS: Of 252 patients, 40.1% died in the hospital, and 33.3% died in the ICU. The qSOFA score had a poor discriminatory ability for both the hospital (AUROC: 0.610 [95% CI: 0.538 to 0.681]; cut-off value: ≥2.5; sensitivity: 34.7%; specificity: 84.1%; PAUROC = 0.003) and ICU (AUROC: 0.619 [95% CI: 0.544 to 0.694]; cutoff value: ≥2.5; sensitivity: 36.9%; specificity: 83.3%; PAUROC = 0.002) mortalities. However, multivariable logistic regression analyses show that the qSOFA score of 3 was independently associated with the increased risk of deaths in both the hospital (adjusted odds ratio, AOR: 3.358; 95% confidence interval, CI: 1.756 to 6.422) and the ICU (AOR: 3.060; 95% CI: 1.651 to 5.671). CONCLUSION: In our study, despite having a poor discriminatory value, the qSOFA score seems worthwhile in predicting mortality in ICU patients with sepsis in limited-resource settings. CLINICAL TRIAL REGISTRATION: Clinical trials registry-India: CTRI/2019/01/016898.

Center for Critical Care Medicine Bach Mai Hospital Hanoi Vietnam

Center for Emergency Medicine Bach Mai Hospital Hanoi Vietnam

Department of Critical Care Emergency Medicine and Clinical Toxicology Faculty of Medicine Ho Chi Minh City University of Medicine and Pharmacy Ho Chi Minh City Vietnam

Department of Emergency and Critical Care Medicine Hanoi Medical University Hanoi Vietnam

Department of Health Organization and Management Faculty of Public Health Thai Binh University of Medicine and Pharmacy Thai Binh Vietnam

Department of Intensive Care and Poison Control Vietnam Czechoslovakia Friendship Hospital Hai Phong Vietnam

Department of Nutrition and Food Safety Faculty of Public Health Thai Binh University of Medicine and Pharmacy Thai Binh Vietnam

Division of Respiratory and Critical Care Medicine Department of Medicine National University Health System Singapore Singapore

Emergency and Critical Care Department Hanoi Medical University Hospital Hanoi Medical University Hanoi Vietnam

Emergency Department Hue Central General Hospital Hue City Thua Thien Hue Vietnam

Emergency Department Thanh Nhan General Hospital Hanoi Vietnam

Faculty of Medicine University of Medicine and Pharmacy Vietnam National University Hanoi Vietnam

FAST and Chronic Programmes Alexandra Hospital National University Health System Singapore Singapore

Intensive Care Department Cho Ray Hospital Ho Chi Minh City Vietnam

Intensive Care Unit Bai Chay General Hospital Quang Ninh Vietnam

Intensive Care Unit Can Tho Central General Hospital Can Tho Vietnam

Intensive Care Unit Da Nang Hospital Da Nang City Vietnam

Intensive Care Unit Dong Da General Hospital Hanoi Vietnam

Intensive Care Unit People's Hospital 115 Ho Chi Minh City Vietnam

Intensive Care Unit Saint Paul General Hospital Hanoi Vietnam

Intensive Care Unit Thai Nguyen National Hospital Thai Nguyen Vietnam

Intensive Care Unit Vinmec Times City International Hospital Hanoi Vietnam

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Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study

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CTRI
CTRI/2019/01/016898