Changes in Nutritional State and Cardiovascular Parameters in Alimentary Obese Children after a Month-Long Stay in Children's Treatment Center

. 2022 Oct 22 ; 9 (11) : . [epub] 20221022

Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid36360338

Grantová podpora
MUNI/A/1133/2021 Masaryk University
P-PooL Masaryk University

Childhood and adolescent obesity has become an important public health issue, as it leads to higher risk of cardio−metabolic, orthopedic, and psychological comorbidities. The aim of this study was to evaluate the changes in nutritional state and cardiovascular system parameters in obese children. Sixty respondents aged 9−17 years with alimentary obesity participated in this research. Anthropometric parameters (body weight (BWT), body mass index (BMI), percentage of body fat (%), waist and hip circumference (WC and HC), waist−hip ratio (WHR)) and cardiovascular parameters (systolic and diastolic blood pressure (SP and DP), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), pulse wave velocity and its variability (PWV and PWVV), and parameters of pulse wave analysis) were measured. Every respondent went through two sets of measurements, the first (I.) after their admission to the children’s hospital and the second (II.) at the end of their one-month-long therapeutic stay. Statistically significant differences between measurements I. and II. were observed in the following parameters: BWT (p < 0.01), BMI (p < 0.01), WC (p < 0.01), HC (p < 0.01), DP (p < 0.01), PWV (p < 0.05), and ABI (p < 0.01). The results of this study show that obesity has a mostly negative impact on the cardiovascular health of affected children, with likely negative results in their adulthood.

Zobrazit více v PubMed

Obesity. [(accessed on 16 July 2022)]. Available online: https://www.who.int/health-topics/obesity.

Pastucha D., Filipčíková R., Horáková D., Radová L., Marinov Z., Malinčíková J., Kocvrlich M., Horák S., Bezdičková M., Dobiáš M. The Incidence of Metabolic Syndrome in Obese Czech Children: The Importance of Early Detection of Insulin Resistance Using Homeostatic Indexes HOMA-IR and QUICKI. Physiol. Res. 2013;62:277–283. doi: 10.33549/physiolres.932438. PubMed DOI

Aggarwal B., Jain V. Obesity in Children: Definition, Etiology and Approach. Indian J. Pediatr. 2018;85:463–471. doi: 10.1007/s12098-017-2531-x. PubMed DOI

Weihrauch-Blüher S., Wiegand S. Risk Factors and Implications of Childhood Obesity. Curr. Obes. Rep. 2018;7:254–259. doi: 10.1007/s13679-018-0320-0. PubMed DOI

Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness. Arter. Thromb. Vasc. Biol. 2005;25:932–943. doi: 10.1161/01.ATV.0000160548.78317.29. PubMed DOI

Nosalski R., Guzik T.J. Perivascular Adipose Tissue Inflammation in Vascular Disease. Br. J. Pharmacol. 2017;174:3496–3513. doi: 10.1111/bph.13705. PubMed DOI PMC

Boutouyrie P., Chowienczyk P., Humphrey J.D., Mitchell G.F. Arterial Stiffness and Cardiovascular Risk in Hypertension. Circ. Res. 2021;128:864–886. doi: 10.1161/CIRCRESAHA.121.318061. PubMed DOI

Dangardt F., Charakida M., Georgiopoulos G., Chiesa S.T., Rapala A., Wade K.H., Hughes A.D., Timpson N.J., Pateras K., Finer N., et al. Association between Fat Mass through Adolescence and Arterial Stiffness: A Population-Based Study from The Avon Longitudinal Study of Parents and Children. Lancet Child Adolesc. Health. 2019;3:474–481. doi: 10.1016/S2352-4642(19)30105-1. PubMed DOI PMC

Correia-Costa A., Correia-Costa L., Caldas Afonso A., Schaefer F., Guerra A., Moura C., Mota C., Barros H., Areias J.C., Azevedo A. Determinants of Carotid-Femoral Pulse Wave Velocity in Prepubertal Children. Int. J. Cardiol. 2016;218:37–42. doi: 10.1016/j.ijcard.2016.05.060. PubMed DOI

Seznam Růstových Grafů Ke Stažení, SZÚ. [(accessed on 16 July 2022)]. Available online: http://www.szu.cz/publikace/data/seznam-rustovych-grafu-ke-stazeni.

Marchesini Reggiani G., Dalle Grave R., Centis E., Marzocchi R., El Ghoch M. Major Factors for Facilitating Change in Behavioral Strategies to Reduce Obesity. Psychol. Res. Behav. Manag. 2013;6:101–110. doi: 10.2147/PRBM.S40460. PubMed DOI PMC

Castelnuovo G., Pietrabissa G., Manzoni G.M., Cattivelli R., Rossi A., Novelli M., Varallo G., Molinari E. Cognitive Behavioral Therapy to Aid Weight Loss in Obese Patients: Current Perspectives. Psychol. Res. Behav. Manag. 2017;10:165–173. doi: 10.2147/PRBM.S113278. PubMed DOI PMC

Shirai K., Utino J., Otsuka K., Takata M. A Novel Blood Pressure-Independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI) J. Atheroscler. Thromb. 2006;13:101–107. doi: 10.5551/jat.13.101. PubMed DOI

Svačinová J., Hrušková J., Jakubík J., Budinskaya K., Hidegová S., Fabšík M., Sieglová H., Kaščáková Z., Novák J., Nováková Z. Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge. Physiol. Res. 2020;69:S433–S441. doi: 10.33549/physiolres.934594. PubMed DOI PMC

Butlin M., Qasem A. Large Artery Stiffness Assessment Using SphygmoCor Technology. Pulse. 2017;4:180–192. doi: 10.1159/000452448. PubMed DOI PMC

Stabouli S., Printza N., Zervas C., Dotis J., Chrysaidou K., Maliahova O., Antza C., Papachristou F., Kotsis V. Comparison of the SphygmoCor XCEL Device with Applanation Tonometry for Pulse Wave Velocity and Central Blood Pressure Assessment in Youth. J. Hypertens. 2019;37:30–36. doi: 10.1097/HJH.0000000000001819. PubMed DOI

Svacinová J., Moudr J., Honzíková N. Baroreflex sensitivity: Diagnostic importance, methods of determination and a model of baroreflex blood-pressure regulation. Ceskoslovenska Fysiol. 2013;62:10–18. PubMed

Kelly D.M., Jones T.H. Testosterone and Obesity. Obes. Rev. 2015;16:581–606. doi: 10.1111/obr.12282. PubMed DOI

Grantham J.P., Henneberg M. The Estrogen Hypothesis of Obesity. PLoS ONE. 2014;9:e99776. doi: 10.1371/journal.pone.0099776. PubMed DOI PMC

Kaplowitz P.B. Link Between Body Fat and the Timing of Puberty. Pediatrics. 2008;121:S208–S217. doi: 10.1542/peds.2007-1813F. PubMed DOI

Nicolaidis S. Environment and Obesity. Metabolism. 2019;100:153942. doi: 10.1016/j.metabol.2019.07.006. PubMed DOI

Guo Y., Yin X., Wu H., Chai X., Yang X. Trends in Overweight and Obesity Among Children and Adolescents in China from 1991 to 2015: A Meta-Analysis. Int. J. Environ. Res. Public Health. 2019;16:4656. doi: 10.3390/ijerph16234656. PubMed DOI PMC

Tchernof A., Després J.-P. Pathophysiology of Human Visceral Obesity: An Update. Physiol. Rev. 2013;93:359–404. doi: 10.1152/physrev.00033.2011. PubMed DOI

Stages of Puberty: A Guide for Males and Females. [(accessed on 17 July 2022)]. Available online: https://www.healthline.com/health/parenting/stages-of-puberty.

Hertiš T., Petek T., Marčun Varda N. The Prevalence of Elevated Blood Pressure in a Sample of Slovene Children and Adolescents: A Pilot Study. Slov. J. Public Health. 2018;57:72–80. doi: 10.2478/sjph-2018-0010. PubMed DOI PMC

Cote A.T., Harris K.C., Panagiotopoulos C., Sandor G.G.S., Devlin A.M. Childhood Obesity and Cardiovascular Dysfunction. J. Am. Coll. Cardiol. 2013;62:1309–1319. doi: 10.1016/j.jacc.2013.07.042. PubMed DOI

Abel E.D., Litwin S.E., Sweeney G. Cardiac Remodeling in Obesity. Physiol. Rev. 2008;88:389–419. doi: 10.1152/physrev.00017.2007. PubMed DOI PMC

Short K.R., Blackett P.R., Gardner A.W., Copeland K.C. Vascular Health in Children and Adolescents: Effects of Obesity and Diabetes. Vasc. Health Risk Manag. 2009;5:973–990. doi: 10.2147/vhrm.s7116. PubMed DOI PMC

Dangardt F., Chen Y., Berggren K., Osika W., Friberg P. Increased Rate of Arterial Stiffening with Obesity in Adolescents: A Five-Year Follow-up Study. PLoS ONE. 2013;8:e57454. doi: 10.1371/journal.pone.0057454. PubMed DOI PMC

Hudson L.D., Rapala A., Khan T., Williams B., Viner R.M. Evidence for Contemporary Arterial Stiffening in Obese Children and Adolescents Using Pulse Wave Velocity: A Systematic Review and Meta-Analysis. Atherosclerosis. 2015;241:376–386. doi: 10.1016/j.atherosclerosis.2015.05.014. PubMed DOI

Tryggestad J.B., Short K.R. Arterial Compliance in Obese Children: Implications for Cardiovascular Health. Exerc. Sport Sci. Rev. 2014;42:175–182. doi: 10.1249/JES.0000000000000024. PubMed DOI PMC

Thayer J.F., Lane R.D. The Role of Vagal Function in the Risk for Cardiovascular Disease and Mortality. Biol. Psychol. 2007;74:224–242. doi: 10.1016/j.biopsycho.2005.11.013. PubMed DOI

Schäfer A., Vagedes J. How Accurate Is Pulse Rate Variability as an Estimate of Heart Rate Variability? A Review on Studies Comparing Photoplethysmographic Technology with an Electrocardiogram. Int. J. Cardiol. 2013;166:15–29. doi: 10.1016/j.ijcard.2012.03.119. PubMed DOI

Tadic M., Cuspidi C. Childhood Obesity and Cardiac Remodeling: From Cardiac Structure to Myocardial Mechanics. J. Cardiovasc. Med. 2015;16:538–546. doi: 10.2459/JCM.0000000000000261. PubMed DOI

Alpert M.A. Obesity Cardiomyopathy: Pathophysiology and Evolution of the Clinical Syndrome. Am. J. Med. Sci. 2001;321:225–236. doi: 10.1097/00000441-200104000-00003. PubMed DOI

Peterson L.R., Waggoner A.D., Schechtman K.B., Meyer T., Gropler R.J., Barzilai B., Dávila-Román V.G. Alterations in Left Ventricular Structure and Function in Young Healthy Obese Women: Assessment by Echocardiography and Tissue Doppler Imaging. J. Am. Coll. Cardiol. 2004;43:1399–1404. doi: 10.1016/j.jacc.2003.10.062. PubMed DOI

Di Salvo G., Pacileo G., Del Giudice E.M., Natale F., Limongelli G., Verrengia M., Rea A., Fratta F., Castaldi B., D’Andrea A., et al. Abnormal Myocardial Deformation Properties in Obese, Non-Hypertensive Children: An Ambulatory Blood Pressure Monitoring, Standard Echocardiographic, and Strain Rate Imaging Study. Eur. Heart J. 2006;27:2689–2695. doi: 10.1093/eurheartj/ehl163. PubMed DOI

Lorch S.M., Sharkey A. Myocardial Velocity, Strain, and Strain Rate Abnormalities in Healthy Obese Children. J. Cardiometab. Syndr. 2007;2:30–34. doi: 10.1111/j.1559-4564.2007.06001.x. PubMed DOI

Jing L., Pulenthiran A., Nevius C.D., Mejia-Spiegeler A., Suever J.D., Wehner G.J., Kirchner H.L., Haggerty C.M., Fornwalt B.K. Impaired Right Ventricular Contractile Function in Childhood Obesity and Its Association with Right and Left Ventricular Changes: A Cine DENSE Cardiac Magnetic Resonance Study. J. Cardiovasc. Magn. Reson. 2017;19:49. doi: 10.1186/s12968-017-0363-5. PubMed DOI PMC

Šudaková M., Budinskaya K., Nováková Z. Evaluation of Diastolic Heart Function Using Echocardiography and Pulse Wave Analysis in Patients After Anthracycline Therapy; Proceedings of the 2021 Computing in Cardiology (CinC); Brno, Czech Republic. 13–15 September 2021; pp. 1–4.

Marčun-Varda N., Nikolic S., Močnik M. Subendocardial Viability Ratio and Ejection Duration as Parameters of Early Cardiovascular Risk in Children. Clin. Nephrol. 2017;88:35–38. doi: 10.5414/CNP88FX09. PubMed DOI

Yang H., Huynh Q.L., Venn A.J., Dwyer T., Marwick T.H. Associations of Childhood and Adult Obesity with Left Ventricular Structure and Function. Int. J. Obes. 2017;41:560–568. doi: 10.1038/ijo.2016.234. PubMed DOI

Lalan S., Blowey D. Comparison between Oscillometric and Intra-Arterial Blood Pressure Measurements in Ill Preterm and Full-Term Neonates. J. Am. Soc. Hypertens. 2014;8:36–44. doi: 10.1016/j.jash.2013.10.003. PubMed DOI

Lu B., Zhou J., Waring M.E., Parker D.R., Eaton C.B. Abdominal Obesity and Peripheral Vascular Disease in Men and Women: A Comparison of Waist-to-Thigh Ratio and Waist Circumference as Measures of Abdominal Obesity. Atherosclerosis. 2010;208:253–257. doi: 10.1016/j.atherosclerosis.2009.06.027. PubMed DOI

Casey S., Lanting S., Oldmeadow C., Chuter V. The Reliability of the Ankle Brachial Index: A Systematic Review. J. Foot Ankle Res. 2019;12:39. doi: 10.1186/s13047-019-0350-1. PubMed DOI PMC

Sundaram M.E., Berg R.L., Economos C., Coleman L.A. The Relationship between Childhood BMI and Adult Serum Cholesterol, LDL, and Ankle Brachial Index. Clin. Med. Res. 2014;12:33–39. doi: 10.3121/cmr.2013.1172. PubMed DOI PMC

Doraiswamy V.A., Giri J., Mohler E. Premature Peripheral Arterial Disease–Difficult Diagnosis in Very Early Presentation. Int. J. Angiol. 2009;18:45–47. doi: 10.1055/s-0031-1278323. PubMed DOI PMC

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...