Immunomodulatory Agents for Multiple Myeloma
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu úvodníky
PubMed
36497241
PubMed Central
PMC9739922
DOI
10.3390/cancers14235759
PII: cancers14235759
Knihovny.cz E-zdroje
The treatment of multiple myeloma (MM) has undergone a significant paradigm shift in the last 20 years, from conventional chemotherapy to more tumor-specific treatments, based on the interference with pathogenesis of the malignant clone as well as the bone microenvironment [...].
Zobrazit více v PubMed
Singhal S., Mehta J. Thalidomide for relapsed or refractory myeloma. In: Chanan-Khan A.A., editor. Immunomodulating Drugs for the Treatment of Cancer. Lippincott Williams and Wilkins; Baltimore, MD, USA: 2011. pp. 51–60.
Singhal S., Mehta J., Desikan R., Ayers D., Roberson P., Eddlemon P., Munshi N., Anaissie E., Wilson C., Dhodapkar M., et al. Antitumor Activity of Thalidomide in Refractory Multiple Myeloma. N. Engl. J. Med. 1999;341:1565–1571. doi: 10.1056/nejm199911183412102. PubMed DOI
Barlogie B., Desikan R., Eddlemon P., Spencer T., Zeldis J., Munshi N., Badros A., Zangari M., Anaissie E., Epstein J., et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: Identification of prognostic factors in a phase 2 study of 169 patients. Blood. 2001;98:492–494. doi: 10.1182/blood.v98.2.492. PubMed DOI
Glasmacher A., Hahn C., Hoffmann F., Naumann R., Goldschmidt H., Lilienfeld-Toal M., Orlopp K., Schmidt-Wolf I., Gorschlüter M. A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 2006;132:584–593. doi: 10.1111/j.1365-2141.2005.05914.x. PubMed DOI
Fermand J.-P., Jaccard A., Macro M., Uzunhan Y., Allard C., Castaigne S., Divine M., Mariette X., Leblond V., Chevret S. A Randomized Comparison of Dexamethasone + Thalidomide (Dex/Thal) vs Dex + Placebo (Dex/P) in Patients (pts) with Relapsing Multiple Myeloma (MM) Blood. 2006;108:3563. doi: 10.1182/blood.v108.11.3563.3563. DOI
Palumbo A., Bringhen S., Caravita T., Merla E., Capparella V., Callea V., Cangialosi C., Grasso M., Rossini F., Galli M., et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial. Lancet. 2006;367:825–831. doi: 10.1016/s0140-6736(06)68338-4. PubMed DOI
Attal M., Harousseau J.-L., Leyvraz S., Doyen C., Hulin C., Benboubker L., Yakoub-Agha I., Bourhis J.-H., Garderet L., Pegourie B., et al. Maintenance therapy with thalidomide improves survival in patients with multiple myeloma. Blood. 2006;108:3289–3294. doi: 10.1182/blood-2006-05-022962. PubMed DOI
Abdelkefi A., Ladeb S., Torjman L., Ben Othman T., Lakhal A., Ben Romdhane N., El Omri H., Elloumi M., Belaaj H., Jeddi R., et al. Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: Results of a multicenter randomized clinical trial. Blood. 2008;111:1805–1810. doi: 10.1182/blood-2007-07-101212. PubMed DOI
Zemanova M., Scudla V., Adam Z., Gregora E., Pour L., Minarik J., Pavlicek P., Pika T., Bacovsky J. Low-dose thalidomide regimens in therapy of relapsed or refractory multiple myeloma. Neoplasma. 2008;55:345–349. PubMed
Lokhorst H.M., Schmidt-Wolf I., Sonneveld P., Van Der Holt B., Martin H., Barge R., Bertsch U., Schlenzka J., Bos G.M., Croockewit S., et al. Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma. Haematologica. 2008;93:124–127. doi: 10.3324/haematol.11644. PubMed DOI
Morgan G.J., Davies F.E., Gregory W.M., Bell S.E., Szubert A.J., Coy N.N., Cook G., Feyler S., Johnson P.R.E., Rudin C., et al. Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results. Haematologica. 2012;97:442–450. doi: 10.3324/haematol.2011.043372. PubMed DOI PMC
Zervas K., Mihou D., Katodritou E., Pouli A., Mitsouli C., Anagnostopoulos A., Delibasi S., Kyrtsonis M., Terpos E., Zikos P., et al. VAD-doxil versus VAD-doxil plus thalidomide as initial treatment for multiple myeloma: Results of a multicenter randomized trial of the Greek myeloma study group. Ann. Oncol. 2007;18:1369–1375. doi: 10.1093/annonc/mdm178. PubMed DOI
Minarik J., Sandecka V., Maisnar V., Gregora E., Spicka I., Starostka D., Plonkova H., Jarkovsky J., Walterová L., Wróbel M., et al. 10 years of experience with thalidomide in multiple myeloma patients: Report of the Czech Myeloma Group. Leuk. Res. 2013;37:1063–1069. doi: 10.1016/j.leukres.2013.06.019. PubMed DOI
Krejci M., Gregora E., Straub J., Minarik J., Scudla V., Adam Z., Krivanova A., Pour L., Zahradova L., Buchler T., et al. Similar efficacy of thalidomide- and bortezomib-based regimens for first relapse of multiple myeloma. Ann. Hematol. 2011;90:1441–1447. doi: 10.1007/s00277-011-1206-3. PubMed DOI
Mileshkin L., Stark R., Day B., Seymour J.F., Zeldis J.B., Prince H.M. Development of Neuropathy in Patients With Myeloma Treated With Thalidomide: Patterns of Occurrence and the Role of Electrophysiologic Monitoring. J. Clin. Oncol. 2006;24:4507–4514. doi: 10.1200/jco.2006.05.6689. PubMed DOI
Kumar S., Rajkumar S.V. Thalidomide and lenalidomide in the treatment of multiple myeloma. Eur. J. Cancer. 2006;42:1612–1622. doi: 10.1016/j.ejca.2006.04.004. PubMed DOI
D’Amato R.J., Loughnan M.S., Flynn E., Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. Sci. USA. 1994;91:4082–4085. doi: 10.1073/pnas.91.9.4082. PubMed DOI PMC
Anderson K.C. Lenalidomide and Thalidomide: Mechanisms of Action—Similarities and Differences. Semin. Hematol. 2005;42:S3–S8. doi: 10.1053/j.seminhematol.2005.10.001. PubMed DOI
Stephens T.D., Bunde C.J., Fillmore B.J. Mechanism of action in thalidomide teratogenesis. Biochem. Pharmacol. 2000;59:1489–1499. doi: 10.1016/s0006-2952(99)00388-3. PubMed DOI
Vallet S., Palumbo A., Raje N., Boccadoro M., Anderson K.C. Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leuk. Lymphoma. 2008;49:1238–1245. doi: 10.1080/10428190802005191. PubMed DOI
Ito T., Ando H., Suzuki T., Ogura T., Hotta K., Imamura Y., Yamaguchi Y., Handa H. Identification of a Primary Target of Thalidomide Teratogenicity. Science. 2010;327:1345–1350. doi: 10.1126/science.1177319. PubMed DOI
Vrábel D., Vrábel D., Pour L., Pour L., Ševčíková S., Ševčíková S. The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma. Blood Rev. 2019;34:56–66. doi: 10.1016/j.blre.2018.11.003. PubMed DOI
Ito T., Handa H. Molecular mechanisms of thalidomide and its derivatives. Proc. Jpn. Acad. Ser. B. 2020;96:189–203. doi: 10.2183/pjab.96.016. PubMed DOI PMC
Yamanaka S., Murai H., Saito D., Abe G., Tokunaga E., Iwasaki T., Takahashi H., Takeda H., Suzuki T., Shibata N., et al. Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF. EMBO J. 2021;40:e105375. doi: 10.15252/embj.2020105375. PubMed DOI PMC
Palumbo A., Falco P., Corradini P., Falcone A., Di Raimondo F., Giuliani N., Crippa C., Ciccone G., Omedè P., Ambrosini M.T., et al. Melphalan, Prednisone, and Lenalidomide Treatment for Newly Diagnosed Myeloma: A Report From the GIMEMA—Italian Multiple Myeloma Network. J. Clin. Oncol. 2007;25:4459–4465. doi: 10.1200/jco.2007.12.3463. PubMed DOI
Weber D.M., Chen C., Niesvizky R., Wang M., Belch A., Stadtmauer E.A., Siegel D., Borrello I., Rajkumar S.V., Chanan-Khan A.A., et al. Lenalidomide plus Dexamethasone for Relapsed Multiple Myeloma in North America. N. Engl. J. Med. 2007;357:2133–2142. doi: 10.1056/nejmoa070596. PubMed DOI
Dimopoulos M., Spencer A., Attal M., Prince H.M., Harousseau J.-L., Dmoszynska A., Miguel J.S., Hellmann A., Facon T., Foà R., et al. Lenalidomide plus Dexamethasone for Relapsed or Refractory Multiple Myeloma. N. Engl. J. Med. 2007;357:2123–2132. doi: 10.1056/nejmoa070594. PubMed DOI
Gay F., Hayman S.R., Lacy M.Q., Buadi F., Gertz M.A., Kumar S., Dispenzieri A., Mikhael J.R., Bergsagel P.L., Dingli D., et al. Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: A comparative analysis of 411 patients. Blood. 2010;115:1343–1350. doi: 10.1182/blood-2009-08-239046. PubMed DOI PMC
Rajkumar S.V., Hayman S.R., Lacy M.Q., Dispenzieri A., Geyer S.M., Kabat B., Zeldenrust S.R., Kumar S., Greipp P.R., Fonseca R., et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood. 2005;106:4050–4053. doi: 10.1182/blood-2005-07-2817. PubMed DOI PMC
Rajkumar S.V., Jacobus S., Callander N.S., Fonseca R., Vesole D.H., E Williams M., Abonour R., Siegel D.S., Katz M., Greipp P.R. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial. Lancet Oncol. 2010;11:29–37. doi: 10.1016/s1470-2045(09)70284-0. PubMed DOI PMC
Van Beurden-Tan C.H.Y., Franken M.G., Blommestein H.M., Groot C.A.U.-D., Sonneveld P. Systematic Literature Review and Network Meta-Analysis of Treatment Outcomes in Relapsed and/or Refractory Multiple Myeloma. J. Clin. Oncol. 2017;35:1312–1319. doi: 10.1200/jco.2016.71.1663. PubMed DOI
Richardson P.G., Xie W., Jagannath S., Jakubowiak A., Lonial S., Raje N.S., Alsina M., Ghobrial I.M., Schlossman R.L., Munshi N.C., et al. A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. Blood. 2014;123:1461–1469. doi: 10.1182/blood-2013-07-517276. PubMed DOI PMC
Stewart A.K., Rajkumar S.V., Dimopoulos M.A., Masszi T., Špička I., Oriol A., Hájek R., Rosiñol L., Siegel D.S., Mihaylov G.G., et al. Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma. New Engl. J. Med. 2015;372:142–152. doi: 10.1056/nejmoa1411321. PubMed DOI
Lonial S., Dimopoulos M., Palumbo A., White D., Grosicki S., Spicka I., Walter-Croneck A., Moreau P., Mateos M.V., Magen H., et al. Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma. N. Engl. J. Med. 2015;373:621–631. doi: 10.1056/nejmoa1505654. PubMed DOI
Dimopoulos M.A., San-Miguel J., Belch A., White D., Benboubker L., Cook G., Leiba M., Morton J., Ho P.J., Kim K., et al. Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: Updated analysis of POLLUX. Haematologica. 2018;103:2088–2096. doi: 10.3324/haematol.2018.194282. PubMed DOI PMC
Facon T., Kumar S., Plesner T., Orlowski R.Z., Moreau P., Bahlis N., Basu S., Nahi H., Hulin C., Quach H., et al. Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma. N. Engl. J. Med. 2019;380:2104–2115. doi: 10.1056/nejmoa1817249. PubMed DOI PMC
Attal M., Lauwers-Cances V., Marit G., Caillot D., Moreau P., Facon T., Stoppa A.M., Hulin C., Benboubker L., Garderet L., et al. Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple Myeloma. N. Engl. J. Med. 2012;366:1782–1791. doi: 10.1056/nejmoa1114138. PubMed DOI
Zhu Y.X., Kortuem K.M., Stewart A.K. Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk. Lymphoma. 2012;54:683–687. doi: 10.3109/10428194.2012.728597. PubMed DOI PMC
McCurdy A.R., Lacy M.Q. Pomalidomide and its clinical potential for relapsed or refractory multiple myeloma: An update for the hematologist. Ther. Adv. Hematol. 2013;4:211–216. doi: 10.1177/2040620713480155. PubMed DOI PMC
Miguel J.S., Weisel K., Moreau P., Lacy M., Song K., Delforge M., Karlin L., Goldschmidt H., Banos A., Oriol A., et al. Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): A randomised, open-label, phase 3 trial. Lancet Oncol. 2013;14:1055–1066. doi: 10.1016/s1470-2045(13)70380-2. PubMed DOI
Richardson P.G., Oriol A., Beksac M., Liberati A.M., Galli M., Schjesvold F., Lindsay J., Weisel K., White D., Facon T., et al. Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): A randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20:781–794. doi: 10.1016/s1470-2045(19)30152-4. PubMed DOI
Dimopoulos M.A., Dytfeld D., Grosicki S., Moreau P., Takezako N., Hori M., Leleu X., Leblanc R., Suzuki K., Raab M.S., et al. Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma. N. Engl. J. Med. 2018;379:1811–1822. doi: 10.1056/nejmoa1805762. PubMed DOI
Attal M., Richardson P.G., Rajkumar S.V., San-Miguel J., Beksac M., Spicka I., Leleu X., Schjesvold F., Moreau P., Dimopoulos M.A., et al. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): A randomised, multicentre, open-label, phase 3 study. Lancet. 2019;394:2096–2107. doi: 10.1016/s0140-6736(19)32556-5. PubMed DOI
Chari A., Suvannasankha A., Fay J.W., Arnulf B., Kaufman J.L., Ifthikharuddin J.J., Weiss B.M., Krishnan A., Lentzsch S., Comenzo R., et al. Daratumumab plus pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma. Blood. 2017;130:974–981. doi: 10.1182/blood-2017-05-785246. PubMed DOI PMC
Holstein S.A., McCarthy P.L. Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience. Drugs. 2017;77:505–520. doi: 10.1007/s40265-017-0689-1. PubMed DOI PMC