Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a new disease in children and adolescents that occurs after often asymptomatic or mild COVID-19. It can be manifested by different clinical symptomatology and varying severity of disease based on multisystemic inflammation. The aim of this retrospective cohort trial was to describe the initial clinical presentation, diagnostics, therapy and clinical outcome of paediatric patients with a diagnosis of PIMS-TS admitted to one of the 3 PICUs. All paediatric patients who were admitted to the hospital with a diagnosis of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) during the study period were enrolled in the study. A total of 180 patients were analysed. The most common symptoms upon admission were fever (81.6%, n = 147), rash (70.6%, n = 127), conjunctivitis (68.9%, n = 124) and abdominal pain (51.1%, n = 92). Acute respiratory failure occurred in 21.1% of patients (n = 38). Vasopressor support was used in 20.6% (n = 37) of cases. Overall, 96.7% of patients (n = 174) initially tested positive for SARS-CoV-2 IgG antibodies. Almost all patients received antibiotics during in-hospital stays. No patient died during the hospital stay or after 28 days of follow-up. Initial clinical presentation and organ system involvement of PIMS-TS including laboratory manifestations and treatment were identified in this trial. Early identification of PIMS-TS manifestation is essential for early treatment and proper management of patients.

Department of Anaesthesiology Resuscitation and Intensive Care Medicine 2nd Medical Faculty Charles University and University Hospital Motol 150 06 Prague Czech Republic

Department of Applied Mathematics Faculty of Electrical Engineering and Computer Science VSB Technical University of Ostrava 708 00 Ostrava Czech Republic

Department of Paediatric Anaesthesiology and Intensive Care Medicine University Hospital Brno and Faculty of Medicine Masaryk University Kamenice 5 625 00 Brno Czech Republic

Department of Paediatrics University Hospital Brno and Faculty of Medicine Masaryk University Kamenice 5 625 00 Brno Czech Republic

Department of Pediatric Infectious Diseases University Hospital Brno Kamenice 5 625 00 Brno Czech Republic

Department of Pediatrics 2nd Medical Faculty Charles University and University Hospital Motol 150 06 Prague Czech Republic

Department of Pediatrics Klinik Donaustadt Langobardenstraße 122 1020 Vienna Austria

Department of Simulation Medicine Faculty of Medicine Masaryk University Kamenice 5 625 00 Brno Czech Republic

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