Carbosilane ruthenium metallodendrimer as alternative anti-cancer drug carrier in triple negative breast cancer mouse model: A preliminary study
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
36858135
DOI
10.1016/j.ijpharm.2023.122784
PII: S0378-5173(23)00204-1
Knihovny.cz E-resources
- Keywords
- Anticancer drug, Cytotoxicity, Dendrimer, Drug delivery, In vitro, In vivo, Molecular dynamics, Molecular simulations, Ruthenium, Tumor weight,
- MeSH
- Coordination Complexes * chemistry MeSH
- Humans MeSH
- Molecular Structure MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Drug Carriers MeSH
- Computer Simulation MeSH
- Antineoplastic Agents * chemistry MeSH
- Ruthenium * chemistry MeSH
- Drug Screening Assays, Antitumor MeSH
- Triple Negative Breast Neoplasms * drug therapy MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- carbosilane MeSH Browser
- Coordination Complexes * MeSH
- Drug Carriers MeSH
- Antineoplastic Agents * MeSH
- Ruthenium * MeSH
The carbosilane metallodendrimer G1-[[NCPh(o-N)Ru(η6- p-cymene)Cl]Cl]4 (CRD13), based on an arene Ru(II) complex coordinated to imino-pyridine surface groups, has been conjugated with anti-cancer drugs. Ruthenium in the positively-charged dendrimer structure allows this nanoparticle to be considered as an anticancer drug carrier, made more efficient because ruthenium has anticancer properties. The ability of CRD13 to form complexes with Doxorubicin (DOX), 5-Fluorouracil (5-Fu), and Methotrexate (MTX) has been evaluated using zeta potential measurement, transmission electron microscopy (TEM) and computer simulation. The results show that it forms stable nanocomplexes with all those drugs, enhancing their effectiveness against MDA-MB-231 cancer cells. In vivo tests indicate that the CRD13/DOX system caused a decrease of tumor weight in mice with triple negative breast cancer. However, the tumors were most visibly reduced when naked dendrimers were injected.
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