It is estimated that nearly one-third of the world's human population is infected with Toxoplasma gondii (Nicolle et Manceaux, 1908). Human infection is commonly asymptomatic, multifaceted, and can manifest in severe pathological forms in congenital toxoplasmosis and immunocompromised individuals. This study attempted to recognise the seroprevalence of T. gondii infection in Iranian residents referred to medical laboratories for toxoplasmosis tests throughout the country. This retrospective cross-sectional study was conducted from 2015 to 2019 on individuals referred to diagnostic laboratories in 26 provinces, and these laboratories sent their samples to the referral centres. Accordingly, data associated with serodiagnosis of toxoplasmosis, age, sex, anti-T. gondii IgG, and IgM status in Iranian residents were collected from two referral diagnostic laboratories. All individuals were evaluated using the antibody immunocapture-chemiluminescence assay (CLIA) method with the Immulite®2000s XPi system. In this study, the first large-scale assay of T. gondii infection in Iran, an overall seroprevalence of 30.4% was among 35,047 patients examined. The highest IgM seropositivity rate was in the 10-20 years old patients. In addition, this study showed a very different prevalence of T. gondii across the country, highest in the humid areas, such as the Caspian Sea basin in the North, and the North West with seroprevalence of 48.6%.

Acquired Immunodeficiency Research Centre Isfahan University of Medical Sciences

Department of Medical Parasitology and Mycology School of Medicine Urmia University of Medical Sciences Urmia Iran

Department of Parasitology and Mycology School of Medicine Isfahan University of Medical Sciences Isfahan Iran

Student Research Committee Isfahan University of Medical Sciences Isfahan Iran

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Aguirre A.A., Longcore T., Barbieri M., Dabritz H., Hill D., Klein P.N., Lepczyk C., Lilly E.L., McLeod R., Milcarsky J., Murphy C.E., Su C., VanWormer E., Yolken R., Sizemore G.C. 2019: The One Health approach to toxoplasmosis: epidemiology, control, and prevention strategies. Ecohealth 16: 378-390. PubMed DOI

Ahmadpour E., Daryani A., Sharif M., Sarvi S., Aarabi M., Mizani A., Rahimi M.T., Shokri A. 2014: Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis. J. Infect. Dev. Ctries. 8: 1503-1510. PubMed DOI

Almeria S., Cano-Terriza D., Prieto P., Dubey J.P., Jimenez-Martin D., Castro-Scholten S., Paniagua J., Garcia-Bocanegra I. 2021: Seroprevalence and risk factors of Toxoplasma gondii infection in wild ungulates that cohabit in a natural park with human-animal interaction in the Mediterranean ecosystem. Zoonoses Public Health 68: 263-270. PubMed DOI

Asgari Q., Motazedian M.H., Khazanchin A., Mehrabani D., Naderi Shahabadi S. 2021: High prevalence of Toxoplasma gondii infection in type I Diabetic patients. J. Parasitol. Res. 2021: 8881908. PubMed DOI

Attias M., Teixeira D.E., Benchimol M., Vommaro R.C., Crepaldi P.H., De Souza W. 2020: The life-cycle of Toxoplasma gondii reviewed using animations. Parasit. Vectors 13: 588. PubMed DOI

Ben-Harari R.R., Connolly M.P. 2019: High burden and low awareness of toxoplasmosis in the United States. Postgrad. Med. J. 131: 103-108. PubMed DOI

Daher D., Shaghlil A., Sobh E., Hamie M., Hassan M.E., Moumneh M.B., Itani S., El Hajj R., Tawk L., El Sabban M., El Hajj H. 2021: Comprehensive overview of Toxoplasma gondii-induced and associated diseases. Pathogens 10:1351. PubMed DOI

Daryani A., Sarvi S., Aarabi M., Mizani A., Ahmadpour E., Shokri A., Rahimi M.T., Sharif M. 2014: Seroprevalence of Toxoplasma gondii in the Iranian general population: a systematic review and meta-analysis. Acta Trop. 137: 185-194. PubMed DOI

Dubey J.P., Jones J.L. 2008: Toxoplasma gondii infection in humans and animals in the United States. Int. J. Parasitol. 38: 1257-1278. PubMed DOI

Foroutan M., Dalvand S., Daryani A., Ahmadpour E., Majidiani H., Khademvatan S., Abbasi E. 2019: Rolling up the pieces of a puzzle: a systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran. Alexandria J. Med. 54: 189-196. DOI

Hill D.E., Dubey J.P. 2018: Toxoplasma gondii. In: Y.R. Ortega and C.R. Sterling (Eds.), Foodborne Parasites. Springer, Cham, pp. 119-138. DOI

Hlaváčová J., Flegr J., Fiurašková K., Kaňková S. 2021: Relationship between latent toxoplasmosis and depression in clients of a center for assisted reproduction. Pathogens 10: 1052. PubMed DOI

Hosseini S.A., Sharif M., Sarvi S., Janbabai G., Keihanian S., Abediankenari S., Gholami S., Amouei A., Javidnia J., Saberi R., Shekarriz R., Daryani A. 2021: Toxoplasmosis among cancer patients undergoing chemotherapy: a population study based on the serological, molecular and epidemiological aspects. Trans. R. Soc. Trop. Med. Hyg. 115: 677-686. PubMed DOI

Inceboz M., Inceboz T. 2021: Toxoplasmosis and neuropsychological effects. Turkiye Parazitol. Derg. 45: 49-55. PubMed DOI

Kalogeropoulos D., Sakkas H., Mohammed B., Vartholomatos G., Malamos K., Sreekantam S., Kanavaros P., Kalogeropoulos C. 2021: Ocular toxoplasmosis: a review of the current diagnostic and therapeutic approaches. Int. Ophthalmol. 42: 295-321. PubMed DOI

Khademi S.Z., Ghaffarifar F., Dalimi A., Davoodian P., Abdoli A. 2019: Prevalence and risk factors of Toxoplasma gondii infection among pregnant women in Hormozgan province, south of Iran. Iran. J. Parasitol. 14: 167-173. DOI

Khosravi S, Eslamirad Z., Rafiei F. 2016: The overview on studies related to the prevalence of neonatal toxoplasmosis in Iran. Iran. J. Clin. Infect. Dis. 3: 91-96.

Mendoza-Larios L.A., Garcia-Dolores F., Sanchez-Anguiano L.F., Hernandez-Tinoco J., Alvarado-Esquivel C. 2021: Association between suicide and Toxoplasma gondii seropositivity. Pathogens 10: 1094. PubMed DOI

Molan A N.K., Hunter M, Wang W. 2019: Global status of Toxoplasma gondii infection: systematic review and prevalence snapshots. Trop. Biomed. 36: 898-925. PubMed

Montoya J.G., Liesenfeld O. 2004: Toxoplasmosis. Lancet 363: 1965-1976. PubMed DOI

Moshfe A., Arefkhah N., Sarkari B., Kazemi S., Mardani A. 2018: Toxoplasma gondii in blood donors: a study in Boyer-Ahmad county, southwest Iran. Interdiscip. Perspect. Infect. Dis. 2018: 3813612. PubMed DOI

Mousavi-Hasanzadeh M., Sarmadian H., Ghasemikhah R., Didehdar M., Shahdoust M., Maleki M., Taheri M. 2020: Evaluation of Toxoplasma gondii infection in western Iran: seroepidemiology and risk factors analysis. Trop. Med. Health 48: 35. PubMed DOI

Nahvi M., Shojaee S., Keshavarz H., Salimi M., Mohebali M. 2019: Detection of Toxoplasma gondii in cord blood samples from neonates in Tehran, Iran. Iran. J. Public Health 48: 912-916. DOI

Nayeri T., Sarvi S., Moosazadeh M., Amouei A., Hosseininejad Z., Daryani A. 2020: The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: a systematic review and meta-analysis. PLOS Negl. Trop. Dis. 14: e0008103. PubMed DOI

Nayeri T., Sarvi S., Sharif M., Daryani A. 2021: Toxoplasma gondii: a possible etiologic agent for Alzheimer's disease. Heliyon 7: e07151. PubMed DOI

Rasti S., Hassanzadeh M., Soliemani A., Hooshyar H., Mousavi S.G., Nikoueinejad H., Abdoli A. 2016: Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran. Ren. Fail. 38: 970-973. PubMed DOI

Robert-Gangneux F., Darde M.L. 2012: Epidemiology of and diagnostic strategies for toxoplasmosis. Clin. Microbiol. Rev. 25: 264-296. PubMed DOI

Roberts T., Murrell K.D., Marks S. 1994: Economic losses caused by foodborne parasitic diseases. Parasitol. Today 10: 419-423. PubMed DOI

Saki J., Eskandari E., Feghhi M. 2020: Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods. Int. Ophthalmol. 40: 2151-2157. PubMed DOI

Sobati H. 2020: Chemiluminescent microparticle immunoassay-based detection and prevalence of Toxoplasma gondii infection in childbearing women (Iran). J. Parasit. Dis. 44: 273-280. PubMed DOI

Thebault A., Kooh P., Cadavez V., Gonzales-Barron U., Villena I. 2021: Risk factors for sporadic toxoplasmosis: a systematic review and meta-analysis. Microb. Risk Anal. 17: 100116. DOI

Torgerson P.R., Mastroiacovo P. 2013: The global burden of congenital toxoplasmosis: a systematic review. Bull. World Health Organ. 91: 501-508. PubMed DOI

Weiss L.M., Dubey J.P. 2009: Toxoplasmosis: a history of clinical observations. Int. J. Parasitol. 39: 895-901. PubMed DOI