The Effects of Quercetin on Apoptosis and Antioxidant Activity in a Renal Ischemia/Reperfusion Injury Animal Model
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
36972618
DOI
10.1055/a-1999-7600
Knihovny.cz E-zdroje
- MeSH
- akutní poškození ledvin * farmakoterapie metabolismus MeSH
- antioxidancia metabolismus MeSH
- apoptóza MeSH
- cytokiny metabolismus MeSH
- ischemie komplikace metabolismus MeSH
- krysa rodu Rattus MeSH
- ledviny MeSH
- NF-kappa B metabolismus farmakologie terapeutické užití MeSH
- oxidační stres MeSH
- potkani Wistar MeSH
- quercetin farmakologie terapeutické užití MeSH
- reperfuzní poškození * farmakoterapie metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antioxidancia MeSH
- cytokiny MeSH
- NF-kappa B MeSH
- quercetin MeSH
Renal ischemia-reperfusion injury (IRI) is considered as one of the most prevalent causes of acute kidney injury (AKI), which can happen in various clinical situations including hypovolemic shock, injury, thrombo-embolism, and after a kidney transplant. This paper aims to evaluate the reno-protective effects of Quercetin in induced ischemia/reperfusion injury by regulating apoptosis-related proteins, inflammatory cytokines, MMP-2, MMP-9, and nuclear factor kappa-light-chain-enhancer inactivated B cells (NF-kB) in rats. The male Wistar rats (n=32) were randomly divided into Sham, untreated IR, and Quercetin-treated IR (gavage and intraperitoneal). Quercetin was given orally and intraperitoneally one hour before inducing ischemia-reperfusion injury . After reperfusion, blood samples and kidneys were collected to assess renal function and inflammatory cytokines, apoptotic signaling proteins, and antioxidants. Urea, creatinine, and MDA levels improved in Quercetin-treated groups with different administration methods. In addition, the activities of other antioxidant in Quercetin-treated rats were higher than those in the IR group. Further, Quercetin inhibited NF-kB signaling, apoptosis-associated factors and produced matrix metalloproteinase protein in the kidneys of rats. Based on the findings, the antioxidant, anti-inflammatory, and anti-apoptotic effects of the Quercetin diminished renal ischemia-reperfusion injury in the rats significantly. It is suggested that a single dosage of Quercetin have a reno-protective impact in the case of renal I/R injury.
Department of Biology Faculty of Science Ferdowsi University of Mashhad Mashhad Iran
Department of Microbiology School of Biology College of Science University of Tehran Tehran Iran
Department of Urology Sina Hospital Tabriz University of Medical Sciences Tabriz Iran
Faculty of Pharmacy in Hradec Kralove Charles University Prague Czech Republic
Kidney Research Center Tabriz University of Medical Sciences Tabriz Iran
Network of Immunity in Infection Malignancy and Autoimmunity Tehran Iran
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