Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract
Status PubMed-not-MEDLINE Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
37093445
PubMed Central
PMC10154448
DOI
10.1007/s40204-023-00219-9
PII: 10.1007/s40204-023-00219-9
Knihovny.cz E-zdroje
- Klíčová slova
- Antibacterial, Anticancer, Green synthesis, Lantana camara, Silver nanoparticles,
- Publikační typ
- časopisecké články MeSH
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
Department of Chemistry and Research Centre NMKRV College for Women Bangaluru 560011 India
Department of Chemistry KLE's P C Jabin Science College Hubballi 580031 India
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Abbai R, Mathiyalagan R, Markus J, et al. Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng. IJN. 2016;11:3131–3143. doi: 10.2147/IJN.S108549. PubMed DOI PMC
Abbasi BH, Nazir M, Muhammad W, et al. A comparative evaluation of the antiproliferative activity against HepG2 liver carcinoma cells of plant-derived silver nanoparticles from basil extracts with contrasting anthocyanin contents. Biomolecules. 2019 doi: 10.3390/biom9080320. PubMed DOI PMC
Abdel-Rahman LH, Al-Farhan BS, Abou El-ezz D, et al. Green biogenic synthesis of silver nanoparticles using aqueous extract of Moringa Oleifera: access to apowerful antimicrobial, anticancer, aesticidal and catalytic agents. J Inorg Organomet Polym. 2022;32:1422–1435. doi: 10.1007/s10904-021-02186-9. DOI
Abeer Mohammed AB, Abd Elhamid MM, Khalil MKM, et al. The potential activity of biosynthesized silver nanoparticles of Pseudomonas aeruginosa as an antibacterial agent against multidrug-resistant isolates from intensive care unit and anticancer agent. Environ Sci Eur. 2022;34:109. doi: 10.1186/s12302-022-00684-2. DOI
Acharya D, Satapathy S, Thathapudi JJ, et al. Biogenic synthesis of silver nanoparticles using marine algae Cladophora glomerata and evaluation of apoptotic effects in human colon cancer cells. Mater Technol. 2020 doi: 10.1080/10667857.2020.1863597. DOI
Acharya D, Satapathy S, Somu P, et al. Apoptotic effect and anticancer activity of biosynthesized silver nanoparticles from marine algae Chaetomorphalinum extract against human colon cancer cell HCT-116. Biol Trace Elem Res. 2021;199:1812–1822. doi: 10.1007/s12011-020-02304-7. PubMed DOI
Aiswariya KS, Jose V. Photo-mediated facile synthesis of silver nanoparticles using Curcuma zanthorrhiza rhizome extract and their in vitro antimicrobial and anticancer activity. J Inorg Organomet Polym. 2021;31:3111–3124. doi: 10.1007/s10904-021-01951-0. DOI
Akintelu SA, Folorunso AS. A review on green synthesis of zinc oxide nanoparticles using plant extracts and its biomedical applications. Bio Nano Sci. 2020;10:848–863. doi: 10.1007/s12668-020-00774-6. DOI
Alvur O, Kucuksayan H, Baygu Y, et al. The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells. Mol Biol Rep. 2022;49:39–50. doi: 10.1007/s11033-021-06817-9. PubMed DOI
Ameen F. Green synthesis spinel ferrite nanosheets and their cytotoxicity and antibacterial activity. Biomass Conv Bioref. 2022 doi: 10.1007/s13399-022-03638-z. DOI
Anil B, Mekala S, Rafi SM, Ravindhranath K. Simple bio-sorbents derived from Mimusopselengi plant for the effective removal of molybdate from industrial wastewater. Biomass Conv Bioref. 2022 doi: 10.1007/s13399-022-02830-5. DOI
Atwan QS, Hayder NH. Eco-friendly synthesis of silver nanoparticles by using green method: improved interaction and application in vitro and in vivo. Iraqi J Agric Sci. 2020;51:201–216. doi: 10.36103/IJAS.V51ISPECIAL.898. DOI
Ayalew AA. Chromatographic and spectroscopic determination of solvent-extracted Lantana camara leaf oil. J Int Med Res. 2020;48:0300060520962344. doi: 10.1177/0300060520962344. PubMed DOI PMC
Banerjee K, Das S, Choudhury P, et al. A novel approach of synthesizing and evaluating the anticancer potential of silver oxide nanoparticles in vitro. Chemotherapy. 2017;62:279–289. doi: 10.1159/000453446. PubMed DOI
Banthia P, Gambhir L, Daga D, et al. Phytogenic synthesis of metallic nanoparticles: application for breast cancer nanomedicine. Vegetos. 2022 doi: 10.1007/s42535-022-00542-9. DOI
Bhat MP, Kumar RS, Almansour AI, et al. Characterization, antimicrobial activity and anticancer activity of Pyrostegiavenusta leaf extract-synthesized silver nanoparticles against COS-7 cell line. Appl Nanosci. 2023;13:2303–2314. doi: 10.1007/s13204-021-02120-y. DOI
Bhuvaneswari R, Xavier RJ, Arumugam M. Facile synthesis of multifunctional silver nanoparticles using mangrove plant Excoecariaagallocha L. for its antibacterial, antioxidant and cytotoxic effects. J Parasit Dis. 2017;41:180–187. doi: 10.1007/s12639-016-0773-6. PubMed DOI PMC
Çınar Ayan İ, Güçlü E, Vural H, Dursun HG. Piceatannol induces apoptotic cell death through activation of caspase-dependent pathway and upregulation of ROS-mediated mitochondrial dysfunction in pancreatic cancer cells. Mol Biol Rep. 2022;49:11947–11957. doi: 10.1007/s11033-022-08006-8. PubMed DOI
Deep A, Verma M, Marwaha RK, et al. Development, characterization and anticancer evaluation of silver nano-particles from Dalbergia Sissoo leaf extracts. Curr Cancer Ther Rev. 2020;16:145–151. doi: 10.2174/1573394715666190820150651. DOI
Dinparvar S, Bagirova M, Allahverdiyev AM, et al. A nanotechnology-based new approach in the treatment of breast cancer: biosynthesized silver nanoparticles using Cuminum cyminum L. seed extract. J PhotochemPhotobiol B Biol. 2020 doi: 10.1016/j.jphotobiol.2020.111902. PubMed DOI
Elangovan K, Elumalai D, Anupriya S, et al. Phyto mediated biogenic synthesis of silver nanoparticles using leaf extract of Andrographis echioides and its bio-efficacy on anticancer and antibacterial activities. J Photochem Photobiol, B. 2015;151:118–124. doi: 10.1016/j.jphotobiol.2015.05.015. PubMed DOI
Esther Nimshi R, Judith Vijaya J, Bououdina M, et al. Green synthesis of functional CuFe2O4@TiO2@rGO nanostructure for magnetic hyperthermia and cytotoxicity of human breast cancer cell line. J Inorg Organomet Polym. 2023 doi: 10.1007/s10904-023-02555-6. DOI
Farshori NN, Siddiqui MA, Al-Oqail MM, et al. Aloe vera-induced apoptotic cell death through ROS generation, cell cycle arrest, and DNA damage in human breast cancer cells. Biologia. 2022;77:2751–2761. doi: 10.1007/s11756-022-01124-5. DOI
Gahlawat G, Choudhury AR. A review on the biosynthesis of metal and metal salt nanoparticles by microbes. RSC Adv. 2019;9:12944–12967. doi: 10.1039/c8ra10483b. PubMed DOI PMC
Ganachari SV, Banapurmath NR, Salimath B, et al. Synthesis techniques for preparation of nanomaterials. In: Martínez LMT, Kharissova OV, Kharisov BI, et al., editors. Handbook of ecomaterials. Cham: Springer International Publishing; 2019. pp. 83–103.
Ganachari SV, Hublikar L, Yaradoddi JS, Math SS. Metal oxide nanomaterials for environmental applications. In: Handbook of ecomater. Berlin: Springer International Publishing; 2019. pp. 2357–2368.
Gnanasangeetha D, Suresh M. A review on green synthesis of metal and metal oxide nanoparticles. Nat Environ Pollut Technol. 2020;19:1789–1800. doi: 10.46488/NEPT.2020.v19i05.002. DOI
Hamida RS, Ali MA, Redhwan A, Bin-Meferij MM. Cyanobacteria—a promising platform in green nanotechnology: a review on nanoparticles fabrication and their prospective applications. Int J Nanomed. 2020;15:6033–6066. doi: 10.2147/IJN.S256134. PubMed DOI PMC
He Y, Li X, Zheng Y, et al. A green approach for synthesizing silver nanoparticles, and their antibacterial and cytotoxic activities. New J Chem. 2018;42:2882–2888. doi: 10.1039/c7nj04224h. DOI
Hemlata MPR, Singh AP, Tejavath KK. Biosynthesis of silver nanoparticles using Cucumis prophetarum aqueous leaf extract and their antibacterial and antiproliferative activity against cancer cell lines. ACS Omega. 2020;5:5520–5528. doi: 10.1021/acsomega.0c00155. PubMed DOI PMC
Hublikar LV, Ganachari SV, Raghavendra N, et al. Green synthesis silver nanoparticles via Eichhornia Crassipes leaves extract and their applications. Curr Res Gr Sustain Chem. 2021 doi: 10.1016/j.crgsc.2021.100212. DOI
Hussain A, Oves M, Alajmi MF, et al. Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities. RSC Adv. 2019;9:15357–15369. doi: 10.1039/C9RA01659G. PubMed DOI PMC
Jacob SJP, Prasad VLS, Sivasankar S, Muralidharan P. Biosynthesis of silver nanoparticles using dried fruit extract of Ficus carica—screening for its anticancer activity and toxicity in animal models. Food Chem Toxicol. 2017;109:951–956. doi: 10.1016/j.fct.2017.03.066. PubMed DOI
Kalaivani R, Maruthupandy M, Muneeswaran T, et al. Synthesis of chitosan mediated silver nanoparticles (Ag NPs) for potential antimicrobial applications. Front Lab Med. 2018;2:30–35. doi: 10.1016/j.flm.2018.04.002. DOI
Kelkawi AHA, Abbasi Kajani A, Bordbar A-K. Green synthesis of silver nanoparticles using Mentha pulegium and investigation of their antibacterial, antifungal and anticancer activity. IET Nanobiotechnol. 2017;11:370–376. doi: 10.1049/iet-nbt.2016.0103. PubMed DOI PMC
Keshri S, Biswas S. Synthesis, physical properties, and biomedical applications of magnetic nanoparticles: a review. Prog Biomater. 2022;11:347–372. doi: 10.1007/s40204-022-00204-8. PubMed DOI PMC
Kim DY, Ryu YS, Lee E-S, et al. DGG-300273, a novel WNT/β-catenin inhibitor, induces apoptotic cell death by activating ROS-BIM signaling in a Wnt-dependent manner in colon cancer cells. Invest New Drugs. 2022 doi: 10.1007/s10637-022-01295-7. PubMed DOI
Ko H-J, Chiou S-J, Tsai C-Y, et al. BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death. Cell Commun Signal. 2022;20:200. doi: 10.1186/s12964-022-01007-x. PubMed DOI PMC
Kochadai N, Khasherao BY, Sinija VRN. Effect of radiofrequency pre-treatment on the extraction of bioactives from Clitoriaternatea and Hibiscus rosa sinensis and insights to enzyme inhibitory activities. Food Bioprocess Technol. 2022;15:571–589. doi: 10.1007/s11947-022-02770-y. DOI
Kumari S, Subramanya HS. Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis. BMC Res Notes. 2020;13:468. doi: 10.1186/s13104-020-05301-0. PubMed DOI PMC
Lakhera S, Devlal K, Rana M, Celik I. Study of nonlinear optical responses of phytochemicals of Clitoriaternatea by quantum mechanical approach and investigation of their anti-Alzheimer activity with in silico approach. Struct Chem. 2023;34:439–454. doi: 10.1007/s11224-022-01981-5. PubMed DOI PMC
Loo YY, Rukayadi Y, Nor-Khaizura M-A-R, et al. In vitro antimicrobial activity of green synthesized silver nanoparticles against selected gram-negative foodborne pathogens. Front Microbiol. 2018 doi: 10.3389/fmicb.2018.01555. PubMed DOI PMC
Mata R, Reddy Nakkala J, Rani Sadras S. Catalytic and biological activities of green silver nanoparticles synthesized from Plumeria alba (frangipani) flower extract. Mater Sci Eng, C. 2015;51:216–225. doi: 10.1016/j.msec.2015.02.053. PubMed DOI
Mbagwu FO, Auta SH, Bankole MT, et al. Biosynthesis and characterization of silver nanoparticles using Bacillus subtilis, Escherichia coli, and leaf extracts of Jatropha and Ocimum species. Int Nano Lett. 2023;13:63–73. doi: 10.1007/s40089-022-00387-9. DOI
Mishra SK, Kannan S. A bimetallic silver-neodymium theranostic nanoparticle with multimodal NIR/MRI/CT imaging and combined chemo-photothermal therapy. Inorg Chem. 2017;56:12054–12066. doi: 10.1021/acs.inorgchem.7b02103. PubMed DOI
Mondal T, Bhatt D, Ramesh K. Bioclimatic modelling of Lantana camara invasion in the Shivalik landscape of Western Himalaya. Trop Ecol. 2022 doi: 10.1007/s42965-022-00264-8. DOI
Motshekga SC. Facile one-pot synthesis of silver nanoparticles embedded alginate beads: synthesis, characterization and antimicrobial activity. Chem Pap. 2023;77:2019–2030. doi: 10.1007/s11696-022-02605-2. DOI
Mufamadi MS, George J, Mazibuko Z, Tshikalange TE. Cancer bionanotechnology: biogenic synthesis of metallic nanoparticles and their pharmaceutical potency. Berlin: Springer Science and Business Media B.V.; 2019.
Nandhini G, Shobana MK. Influence of phytochemicals with iron oxide nanoparticles for biomedical applications: a review. Polym Bull. 2022 doi: 10.1007/s00289-022-04648-7. DOI
Narasimha VR, Latha TS, Pallu R, et al. Anticancer activities of biogenic silver nanoparticles targeting apoptosis and inflammatory pathways in colon cancer cells. J Clust Sci. 2022;33:2215–2231. doi: 10.1007/s10876-021-02143-z. DOI
Nibret E, Krstin S, Wink M. In vitro anti-proliferative activity of selected nutraceutical compounds in human cancer cell lines. BMC Res Notes. 2021;14:18. doi: 10.1186/s13104-020-05435-1. PubMed DOI PMC
Panja S, Choudhuri I, Khanra K, et al. Biological and photocatalytic activity of silver nanoparticle synthesized from ehretialaevisroxb leaves extract. Nano Biomed Eng. 2020;12:104–113. doi: 10.5101/nbe.v12i1.p104-113. DOI
Patil SB, Hublikar LV, Raghavendra N, et al. Synthesis and exploration of anticancer activity of silver nanoparticles using Pandanus amaryllifoliusRoxb. leaf extract: promising approach against lung cancer and breast cancer cell lines. Biologia. 2021;76:3533–3545. doi: 10.1007/s11756-021-00878-8. DOI
Periakaruppan R, Kumar TS, Vanathi P, et al. Phyto-synthesis and characterization of parthenium-mediated iron oxide nanoparticles and an evaluation of their antifungal and antioxidant activities and effect on seed germination. JOM. 2023 doi: 10.1007/s11837-023-05760-3. DOI
Prasad R, Swamy VS. Antibacterial activity of silver nanoparticles synthesized by bark extract of Syzygiumcumini. J Nanoparticles. 2013;2013:e431218. doi: 10.1155/2013/431218. DOI
Prasher P, Singh M, Mudila H. Silver nanoparticles as antimicrobial therapeutics: current perspectives and future challenges. 3 Biotech. 2018;8:411. doi: 10.1007/s13205-018-1436-3. PubMed DOI PMC
Prisrin SA, Priyanga M, Ponvel KM, et al. Plant mediated approach for the fabrication of nano CuO–NiO mixed oxides using aqueous extract of Mimusops Elengi leaf: green synthesis, characterization and antibacterial activity studies. J Clust Sci. 2022;33:765–772. doi: 10.1007/s10876-021-02016-5. DOI
Raghunandan D, Ravishankar B, Sharanbasava G, et al. Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts. Cancer Nanotechnol. 2011;2:57–65. doi: 10.1007/s12645-011-0014-8. PubMed DOI PMC
Rashid B, Anwar A, Shahabuddin S, et al. A comparative study of cytotoxicity of PPG and PEG surface-modified 2-D Ti3C2 mxene flakes on human cancer cells and their photothermal response. Materials. 2021 doi: 10.3390/ma14164370. PubMed DOI PMC
Rawashdeh RY, Qabaja G, Albiss BA. Antibacterial activity of multi-metallic (Ag–Cu–Li) nanorods with different metallic combination ratios against Staphylococcus aureus. BMC Res Notes. 2023;16:23. doi: 10.1186/s13104-023-06284-4. PubMed DOI PMC
Salman G, Pehlivanoglu S, Aydin Acar C, Yesilot S. Anticancer effects of Vitis vinifera L. mediated biosynthesized silver nanoparticles and cotreatment with 5 fluorouracil on HT-29 cell line. Biol Trace Elem Res. 2022;200:3159–3170. doi: 10.1007/s12011-021-02923-8. PubMed DOI
Sarli S, Kalani MR, Moradi A. A potent and safer anticancer and antibacterial taxus-based green synthesized silver nanoparticle. Int J Nanomed. 2020;15:3791–3801. doi: 10.2147/IJN.S251174. PubMed DOI PMC
Sattari R, Khayati GR, Hoshyar R. Biosynthesis of silver-silver chloride nanoparticles using fruit extract of Levisticum Officinale: characterization and anticancer activity against MDA-MB-468 cell lines. J Clust Sci. 2021;32:593–599. doi: 10.1007/s10876-020-01818-3. DOI
Seid MA, Bekele T. Analyses of habitat suitability and invasion potential of Lantana camara under current climate in Amhara Region, Ethiopia: an implication for environmental management. Biol Invasions. 2023;25:153–163. doi: 10.1007/s10530-022-02910-7. DOI
Sen S, Bal T, Rajora AD. Green nanofiber mat from HLM–PVA–Pectin (Hibiscus leaves mucilage–polyvinyl alcohol–pectin) polymeric blend using electrospinning technique as a novel material in wound-healing process. Appl Nanosci. 2022;12:237–250. doi: 10.1007/s13204-021-02295-4. PubMed DOI PMC
Siddiqui N, Pal K, Karmakar P, et al. A dual role of cumin-seed extract towards the silver nanoparticle synthesis and stabilisation and its potential for antibacterial and anticancer activities through oxidative damage. Adv Nat Sci Nanosci Nanotechnol. 2020 doi: 10.1088/2043-6254/ab92fd. DOI
Singh R, Tiwari P, Kumari N, Sharma B. Advances in pharmaceutical biotechnology: recent progress and future applications. Singapore: Springer; 2020. Biomedical applications of green synthesized nanoparticles; pp. 235–245.
Sioss JA, Bhiladvala RB, Pan W, et al. Nanoresonator chip-based RNA sensor strategy for detection of circulating tumor cells: response using PCA3 as a prostate cancer marker. Nanomed Nanotechnol Biol Med. 2012;8:1017–1025. doi: 10.1016/j.nano.2011.11.009. PubMed DOI PMC
Sivamaruthi BS, Ramkumar VS, Archunan G, et al. Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula—in vitro evaluation of anticancer and antimicrobial activity. J Drug Deliv Sci Technol. 2019;51:139–151. doi: 10.1016/j.jddst.2019.02.024. DOI
Stephen S, Thomas T. A review on green synthesis of silver nanoparticles by employing plants of acanthaceae and its bioactivities. Nanomed Res J. 2020;5:215–224. doi: 10.22034/NMRJ.2020.03.002. DOI
Taha ZS, Labena A, Madian HR, et al. Promising applications of seedcake of Jatropha curcas plants: bioethanol production and bio-sorbent material for dye and heavy metal removal. Biomass Conv Bioref. 2022 doi: 10.1007/s13399-022-03193-7. DOI
Takagi T, Inoue H, Fujii S, et al. Erucin inhibits osteoclast formation via suppressing cell–cell fusion molecule DC-STAMP without influencing mineralization by osteoblasts. BMC Res Notes. 2022;15:105. doi: 10.1186/s13104-022-05988-3. PubMed DOI PMC
Teengam P, Siangproh W, Tuantranont A, et al. Multiplex paper-based colorimetric DNA sensor using pyrrolidinyl peptide nucleic acid-induced AgNPs aggregation for detecting MERS-CoV, MTB, and HPV oligonucleotides. Anal Chem. 2017;89:5428–5435. doi: 10.1021/acs.analchem.7b00255. PubMed DOI PMC
Tiwari S, Mishra SN, Kumar D, et al. Modelling the potential risk zone of Lantana camara invasion and response to climate change in eastern India. Ecol Process. 2022;11:10. doi: 10.1186/s13717-021-00354-w. DOI
Tripathi S, Siddiqui MH, Kumar A, Vimal A. Nanoparticles: a promising vehicle for the delivery of therapeutic enzymes. Int Nano Lett. 2022 doi: 10.1007/s40089-022-00391-z. DOI
Uddin MN, Mohebbullah Md, Islam SM, et al. Nigella/honey/garlic/olive oil co-loaded PVA electrospun nanofibers for potential biomedical applications. Prog Biomater. 2022;11:431–446. doi: 10.1007/s40204-022-00207-5. PubMed DOI PMC
Vennila K, Chitra L, Balagurunathan R, Palvannan T. Comparison of biological activities of selenium and silver nanoparticles attached with bioactive phytoconstituents: green synthesized using Spermacocehispida extract. Adv Nat Sci Nano Sci Nanotechnol. 2018 doi: 10.1088/2043-6254/aa9f4d. DOI
Vivekanandhan SC, Chandramohan M, Selvam P. Design, synthesis and characterization of biogenic chloroquine silver nanoparticles as potential anticancer agent against neuroblastoma cells. Asian J Chem. 2018;30:537–540. doi: 10.14233/ajchem.2018.20952. DOI
Wang W, Zhang L, Li N, Zu Y. Chemical composition and in vitro antioxidant, cytotoxicity activities of Zingiber officinale Roscoe essential oil. AJBR. 2012;6:75–80.
Wypij M, Czarnecka J, Świecimska M, et al. Synthesis, characterization and evaluation of antimicrobial and cytotoxic activities of biogenic silver nanoparticles synthesized from Streptomyces xinghaiensis OF1 strain. World J Microbiol Biotechnol. 2018;34:23. doi: 10.1007/s11274-017-2406-3. PubMed DOI PMC
Yaradoddi JS, Kontro MH, Ganachari SV, et al. Handbook of ecomaterials. Cham: Springer International Publishing; 2019. RNA nanotechnology; pp. 3587–3600.
Zada S, Ahmad A, Khan S, et al. Biogenic synthesis of silver nanoparticles using extracts of Leptolyngbya JSC-1 that induce apoptosis in HeLa cell line and exterminate pathogenic bacteria. Artif Cells NanomedBiotechnol. 2018;46:S471–S480. doi: 10.1080/21691401.2018.1499663. PubMed DOI
Phytofabrication of silver nanoparticles using Averrhoa bilimbi leaf extract for anticancer activity