In 2018, the European Society of Gynecological Oncology (ESGO) jointly with the European Society for Radiotherapy and Oncology (ESTRO) and the European Society of Pathology (ESP) published evidence-based guidelines for the management of patients with cervical cancer. Given the large body of new evidence addressing the management of cervical cancer, the three sister societies jointly decided to update these evidence-based guidelines. The update includes new topics to provide comprehensive guidelines on all relevant issues of diagnosis and treatment in cervical cancer. To serve on the expert panel (27 experts across Europe) ESGO/ESTRO/ESP nominated practicing clinicians who are involved in managing patients with cervical cancer and have demonstrated leadership through their expertise in clinical care and research, national and international engagement, profile, and dedication to the topics addressed. To ensure the statements were evidence based, new data identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the international development group. Before publication, the guidelines were reviewed by 155 independent international practitioners in cancer care delivery and patient representatives. These updated guidelines are comprehensive and cover staging, management, follow-up, long-term survivorship, quality of life and palliative care. Management includes fertility sparing treatment, early and locally advanced cervical cancer, invasive cervical cancer diagnosed on a simple hysterectomy specimen, cervical cancer in pregnancy, rare tumors, recurrent and metastatic diseases. The management algorithms and the principles of radiotherapy and pathological evaluation are also defined.

Aarhus University Hospital Aarhus Denmark

Asklepios Clinic Altona Hamburg Germany; Asklepios Comprehensive Tumor Center Hamburg Germany

CHUV Lausanne Switzerland

Clinical Research Unit Institut Bergonie Bordeaux France

Department of Internal Medicine Medical University of Graz Graz Austria

Department of Obstetrics and Gynecology Charles University 1st Faculty of Medicine Prague Czech Republic; General University Hospital Prague Prague Czech Republic

Department of Obstetrics and Gynecology Lund University Hosptial Lund Sweden; Skåne University Hospital Lund Lund Sweden

Department of Palliative Medicine University of Navarra Pamplona Spain

Department of Radiation Oncology Medical University of Vienna Wien Austria

European Institute of Oncology IRCCS Milan Italy

Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy; Catholic University of Sacred Heart Rome Italy

Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy; University Hospitals Strasbourg Strasbourg France

François Baclesse Centre de Lutte Contre le Cancer Caen France

Gynecologic Oncology La Paz University Hospital Madrid Spain

Gynecologic Oncology Nairi Medical Center Yerevan Armenia

Homi Bhabha Cancer Hospital and Research Centre Visakhapatnam Andhra Pradesh India

Hospital Graz 2 Graz Austria; Johannes Kepler Universitat Linz Linz Austria

Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE Lisboa Portugal; Universidade Nova de Lisboa Lisboa Portugal

Medical Oncology Clinica Universidad de Navarra Pamplona Spain

Medical University of Graz Graz Austria

National Cancer Institute Kiev Ukraine

Northern Gynaecological Oncology Centre Gateshead UK

Radiotherapy Erasmus MC Cancer Centre Rotterdam the Netherlands; University Medical Center Rotterdam the Netherlands

Service d'Oncologie Radiothérapie Hôpital Universitaire Pitié Salpêtrière Paris France

University Hospital Careggi Firenze Italy

Vall d'Hebron Institute of Oncology Barcelona Spain; Hospital Universitari Vall d'Hebron Barcelona Spain

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