Pathophysiological and clinical point of view on Kawasaki disease and MIS-C
Jazyk angličtina Země Singapur Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
37453902
PubMed Central
PMC10286520
DOI
10.1016/j.pedneo.2023.05.002
PII: S1875-9572(23)00107-9
Knihovny.cz E-zdroje
- Klíčová slova
- COVID-19, Kawasaki disease, MIS-C,
- MeSH
- COVID-19 * komplikace MeSH
- dítě MeSH
- Kawasakiho syndrom * diagnóza MeSH
- lidé MeSH
- syndrom systémové zánětlivé reakce MeSH
- zánět MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases.
Citace poskytuje Crossref.org
