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Has translation in the nucleus found its purpose?

. 2024 Jan ; 25 (1) : 1-2.

Language English Country England, Great Britain Media print

Document type Journal Article

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PubMed 37592061
DOI 10.1038/s41580-023-00651-6
PII: 10.1038/s41580-023-00651-6
Knihovny.cz E-resources

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Dahlberg, J. E. & Lund, E. Does protein synthesis occur in the nucleus? Curr. Opin. Cel Biol. 16, 335–338 (2004). DOI

Lejeune, F., Ishigaki, Y., Li, X. & Maquat, L. E. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 21, 3536–3545 (2002). PubMed DOI PMC

Reid, D. W. & Nicchitta, C. V. The enduring enigma of nuclear translation. J. Cell Biol. 197, 7–9 (2012). PubMed DOI PMC

Iborra, F. J., Jackson, D. A. & Cook, P. R. Coupled transcription and translation within nuclei of mammalian cells. Science 293, 1139–1142 (2001). PubMed DOI

David, A. et al. Nuclear translation visualized by ribosome-bound nascent chain puromycylation. J. Cell Biol. 197, 45–57 (2012). PubMed DOI PMC

Theodoridis, P. R. et al. Local translation in nuclear condensate amyloid bodies. Proc. Natl Sci. Acad. USA 118, e2014457118 (2021). DOI

Enam, S. U. et al. Puromycin reactivity does not accurately localize translation at the subcellular level. eLife 9, e60303 (2020). PubMed DOI PMC

Al-Jubran, K. et al. Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus. RNA 19, 1669–1683 (2013). PubMed DOI PMC

Schwab, S. R., Li, K. C., Kang, C. & Shastri, N. Constitutive display of cryptic translation products by MHC class I molecules. Science 301, 1367–1371 (2003). PubMed DOI

Sroka, E. M. et al. Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance. Proc. Natl Sci. Acad. USA 120, e2208509120 (2023). DOI

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Translation of bi-directional transcripts enhances MHC-I peptide diversity

. 2025 ; 16 () : 1554561. [epub] 20250317

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