Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation
Jazyk angličtina Země Švýcarsko Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
37680647
PubMed Central
PMC10481336
DOI
10.3389/ti.2023.11589
PII: 11589
Knihovny.cz E-zdroje
- Klíčová slova
- Banff, Delphi, kidney, thrombotic microangiopathy, transplantation,
- MeSH
- analýza nákladů a výnosů MeSH
- biopsie MeSH
- konsensus MeSH
- lidé MeSH
- transplantace ledvin * MeSH
- trombotické mikroangiopatie * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The Thrombotic Microangiopathy Banff Working Group (TMA-BWG) was formed in 2015 to survey current practices and develop minimum diagnostic criteria (MDC) for renal transplant TMA (Tx-TMA). To generate consensus among pathologists and nephrologists, the TMA BWG designed a 3-Phase study. Phase I of the study is presented here. Using the Delphi methodology, 23 panelists with >3 years of diagnostic experience with Tx-TMA pathology listed their MDC suggesting light, immunofluorescence, and electron microscopy lesions, clinical and laboratory information, and differential diagnoses. Nine rounds (R) of consensus resulted in MDC validated during two Rs using online evaluation of whole slide digital images of 37 biopsies (28 TMA, 9 non-TMA). Starting with 338 criteria the process resulted in 24 criteria and 8 differential diagnoses including 18 pathologic, 2 clinical, and 4 laboratory criteria. Results show that 3/4 of the panelists agreed on the diagnosis of 3/4 of cases. The process also allowed definition refinement for 4 light and 4 electron microscopy lesions. For the first time in Banff classification, the Delphi methodology was used to generate consensus. The study shows that Delphi is a democratic and cost-effective method allowing rapid consensus generation among numerous physicians dealing with large number of criteria in transplantation.
AeskuLab Pathology and Department of Pathology Charles University Prague Czechia
Arkana Laboratories Little Rock AR United States
Department of Anatomical Pathology NSW Health Pathology Callaghan NSW Australia
Department of Clinical Microbiology Sahlgrenska University Hospital Gothenburg Sweden
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN United States
Department of Neurology School of Medicine Koç University Istanbul Türkiye
Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston TX United States
Department of Pathology and Immunology Baylor College of Medicine Houston TX United States
Department of Pathology and Laboratory Medicine Emory University Atlanta GA United States
Department of Pathology and Laboratory Medicine Weill Cornell Medicine New York NY United States
Department of Pathology Istanbul Faculty of Medicine Istanbul University Istanbul Türkiye
Department of Pathology Maisonneuve Rosemont Hospital University of Montreal Montreal QC Canada
Department of Pathology Medical University of Vienna Vienna Austria
Department of Pathology Necker Enfants Malades Hospital Université de Paris Cité Paris France
Department of Pathology School of Medicine University of Zagreb Zagreb Croatia
GeoBio Center Ludwig Maximilian University of Munich Munich Germany
Institute for Cell and Tumor Biology University Hospital RWTH Aachen Aachen Germany
Kidney Pancreas Transplantation Instituto de Nefrología Nephrology Buenos Aires Argentina
Krembil Brain Institute University Health Network Toronto ON Canada
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