Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in white populations, accounting for 20% of all cutaneous malignancies. Overall, cSCC mostly has very good prognosis after treatment, with 5-year cure rates greater than 90%. Despite the overall favourable prognosis and the proportionally rare deaths, cSCC is associated with a high total number of deaths due to its high incidence. A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF), the European Society for Radiotherapy and Oncology (ESTRO), the European Union of Medical Specialists (UEMS), the European Academy of Dermatology and Venereology (EADV) and the European Organization of Research and Treatment of Cancer (EORTC), was formed to update recommendations on cSCC, based on current literature and expert consensus. Part 1 of the guidelines addresses the updates on classification, epidemiology, diagnosis, risk stratification, staging and prevention in immunocompetent as well as immunosuppressed patients.

1st Department of Dermatology Aristotle University Thessaloniki Greece

1st Department of Dermatology Venereology National and Kapodistrian University of Athens Andreas Sygros Hospital Athens Greece

Aix Marseille University APHM Hospital Marseille France

Carol Davila University of Medicine and Pharmacy Bucharest Department of Oncologic Dermatology Elias University Hospital Bucharest Bucharest Romania

Centre for Cell Biology and Cutaneous Research Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK

Centre for Dermatooncology Department of Dermatology Eberhard Karls University Tuebingen Germany

Department of Dermatology Coimbra Hospital and University Centre Coimbra Portugal

Department of Dermatology Medical Faculty Military Medical Academy Belgrade Serbia

Department of Dermatology Medical University of Vienna Vienna Austria

Department of Dermatology Papageorgiou Hospital Aristotle University Department of Medicine Thessaloniki Greece

Department of Dermatology University Hospital Erasme Université Libre de Bruxelles Brussels Belgium

Department of Dermatology University Hospital Kiel Germany

Department of Dermatology University of Trieste Trieste Italy

Department of Dermatology Venereology and Allergology Frankfurt University Hospital Frankfurt Germany

Department of Dermatovenereology 3rd Faculty of Medicine Charles University Prague Czech Republic

Department of General and Oncologic Dermatology Ambroise Paré hospital APHP and EA 4340 'Biomarkers in Cancerology and Hemato oncology' UVSQ Université Paris Saclay Boulogne Billancourt France

Department of Medical and Surgical Dermatology Service Hospital Universitario Virgen Macarena Sevilla Spain

Department of Melanoma and Surgical Oncology Royal Prince Alfred Hospital Sydney New South Wales Australia; Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia; Melanoma Institute Australia Sydney New South Wales Australia

Department of Oncology Odense University Hospital Odense Denmark

Dermatology Department of Biotechnological and Applied Clinical Sciences University of L'Aquila L'Aquila Italy

Dermatology Department of Hospital Clinic of Barcelona University of Barcelona IDIBAPS CIBER de enfermedades raras Instituto Carlos 3 Barcelona Spain

Dermatology Unit University of Rome La Sapienza Rome Italy

Division of Cancer Sciences University of Manchester Manchester UK; Department of Medical Oncology Christie NHS Foundation Trust Manchester UK

GROW School for Oncology and Reproduction Maastricht the Netherlands; Department of Dermatology Maastricht University Medical Centre Maastricht University Maastricht the Netherlands

Mount Vernon Cancer Centre East and North NHS Trust Northwood UK

Nantes Université INSERM CNRS Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 EMR6001 Nantes France

Skin Cancer Centre at University Hospital Zurich Zurich Switzerland

Université Paris Cite Dermato Oncology AP HP Hôpital Saint Louis Cancer Institute APHP Nord Université Paris Cite INSERM U976 Paris France

University Medical Center Utrecht and Princess Máxima Center Utrecht the Netherlands; Comprehensive Cancer Center Munich Technical University Munich and Ludwig Maximilian University Munich Germany

UOC di Dermatologia Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy; Dermatologia Università Cattolica del Sacro Cuore Rome Italy

UOC Radioterapia Oncologica Dipartimento di Diagnostica per Immagini Radioterapia Oncologica ed Ematologia Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy

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