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ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer

. 2023 Oct ; 62 (4) : . [epub] 20231019

Language English Country Great Britain, England Media electronic-print

Document type Journal Article, Research Support, Non-U.S. Gov't

BACKGROUND: Screening for lung cancer with low radiation dose computed tomography has a strong evidence base, is being introduced in several European countries and is recommended as a new targeted cancer screening programme. The imperative now is to ensure that implementation follows an evidence-based process that will ensure clinical and cost effectiveness. This European Respiratory Society (ERS) task force was formed to provide an expert consensus for the management of incidental findings which can be adapted and followed during implementation. METHODS: A multi-European society collaborative group was convened. 23 topics were identified, primarily from an ERS statement on lung cancer screening, and a systematic review of the literature was conducted according to ERS standards. Initial review of abstracts was completed and full text was provided to members of the group for each topic. Sections were edited and the final document approved by all members and the ERS Science Council. RESULTS: Nine topics considered most important and frequent were reviewed as standalone topics (interstitial lung abnormalities, emphysema, bronchiectasis, consolidation, coronary calcification, aortic valve disease, mediastinal mass, mediastinal lymph nodes and thyroid abnormalities). Other topics considered of lower importance or infrequent were grouped into generic categories, suitable for general statements. CONCLUSIONS: This European collaborative group has produced an incidental findings statement that can be followed during lung cancer screening. It will ensure that an evidence-based approach is used for reporting and managing incidental findings, which will mean that harms are minimised and any programme is as cost-effective as possible.

Azienda Ospedaliero Universitaria Maggiore della Carità di Novara Novara Italy

Bayer AG Research and Development Pharmaceuticals Radiology Berlin Germany

Charles University 1st Faculty of Medicine Department of Tuberculosis and Respiratory Diseases Prague Czech Republic

Christian Albrechts Universität zu Kiel Faculty of Medicine Kiel Germany

Cochin Hospital APHP Radiology Department Paris France

European Lung Foundation Tipton UK

Galway Clinic Doughiska Galway Ireland

German Center for Lung Research DZL Translational Lung Research Center TLRC Heidelberg Germany

HELIOS Klinikum Emil von Behring GmbH Lungenklinik Heckeshorn Berlin Germany

Humanitas Research Hospital Division of Thoracic and General Surgery Rozzano Italy

Inselspital Universitatsspital Bern Radiation Oncology Bern Switzerland

Institute for Evidence in Medicine Medical Center University of Freiburg Faculty of Medicine University of Freiburg Freiburg im Breisgau Germany

Institute of Tuberculosis and Lung Diseases Warsaw Genetics and Clinical Immunology Warsaw Poland

Kantonsspital Sankt Gallen Radiation Oncology Sankt Gallen Switzerland

Kliniken Maria Hilf GmbH Monchengladbach Nordrhein Westfalen Germany

Maastricht University Medical Centre Department of Radiation Oncology GROW School for Oncology and Developmental Biology Limburg The Netherlands

Medical Centre Leeuwarden Department of Respiratory Medicine Leeuwarden The Netherlands

Medical University of Vienna Department of Biomedical Imaging and Image guided Therapy Vienna Austria

National Koranyi Institute of Pulmonology Department of Radiology Budapest Hungary

Nottingham University Hospitals NHS Trust Nottingham UK

Radboud University Nijmegen Medical Center Department of Radiology Nijmegen The Netherlands

Royal Brompton and Harefield NHS Foundation Trust Radiology London UK

Sotiria General Hospital of Chest Diseases of Athens 7th Respiratory Medicine Department Athens Greece

Sotiria General Hospital of Chest Diseases of Athens Respiratory Medicine Athens Greece

St James's University Hospital Department of Thoracic Surgery Leeds UK

UMCG Groningen The Netherlands

Universitaire Ziekenhuizen Leuven Radiology Leuven Belgium

UniversitatsKlinikum Heidelberg Heidelberg Germany

Université de Paris Paris France

University College Dublin School of Medicine Histopathology Dublin Ireland

University Hospital Antwerp Radiology Edegem Belgium

University Hospital of Salamanca Thoracic Surgery Salamanca Spain

University Hospitals Leuven Thoracic Surgery Leuven Belgium

University of Groningen University Medical Center Groningen Department of Pulmonary Diseases Groningen The Netherlands

University of Heidelberg Diagnostic and Interventional Radiology Heidelberg Germany

University of Latvia Faculty of Medicine Riga Latvia

University of Nottingham Faculty of Medicine and Health Sciences Nottingham UK

UZ Antwerpen MOCA Edegem Belgium

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