A novel FUS::NFATC4 fusion detected in a sarcoma with morphological features overlapping with NFATC2 sarcomas
Language English Country Great Britain, England Media print-electronic
Document type Letter
Grant support
SVV260652
Ministerstvo Školství, Mládeže a Tělovýchovy
ProgramCooperatio,ResearchAreaSURG
Univerzita Karlova v Praze
PubMed
37813649
DOI
10.1111/his.15066
Knihovny.cz E-resources
- Keywords
- FUS::NFATC4, EWSR1-non-ETS fusion, EWSR1/FUS::NFATC2 rearrangement, NFATC2-rearranged sarcoma, NFATC4-rearranged sarcoma, small round-cell sarcoma,
- MeSH
- Oncogene Proteins, Fusion genetics MeSH
- Humans MeSH
- Biomarkers, Tumor MeSH
- Soft Tissue Neoplasms * MeSH
- RNA-Binding Protein EWS MeSH
- RNA-Binding Protein FUS MeSH
- Sarcoma * diagnosis genetics MeSH
- NFATC Transcription Factors MeSH
- Transcription Factors metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Letter MeSH
- Names of Substances
- FUS protein, human MeSH Browser
- Oncogene Proteins, Fusion MeSH
- Biomarkers, Tumor MeSH
- NFATC2 protein, human MeSH Browser
- NFATC4 protein, human MeSH Browser
- RNA-Binding Protein EWS MeSH
- RNA-Binding Protein FUS MeSH
- NFATC Transcription Factors MeSH
- Transcription Factors MeSH
Bioptical Laboratory Ltd Plzen Czech Republic
Cytopathos Ltd Bratislava Slovakia
Department of Pathology Charles University Faculty of Medicine in Plzen Plzen Czech Republic
Department of Pathology Johns Hopkins University School of Medicine Baltimore MD USA
See more in PubMed
Kallen ME, Hornick JL. The 2020 WHO classification: what's new in soft tissue tumor pathology? Am. J. Surg. Pathol. 2021; 45; e1-e23.
Michal M, Rubin BP, Agaimy A et al. EWSR1-PATZ1-rearranged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers. Mod. Pathol. 2021; 34; 770-785.
Perret R, Escuriol J, Velasco V et al. NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker. Mod. Pathol. 2020; 33; 1930-1944.
Torres-Mora J, Fritchie K, Folpe AL et al. Soft tissue and bone tumors with EWSR1/FUS::NFATC2 gene fusions: a clinico-pathologic study of 28 cases emphasizing their broad morphologic spectrum. Lab. Invest. 2023; 103; S72.
Wang GY, Thomas DG, Davis JL et al. EWSR1-NFATC2 translocation-associated sarcoma clinicopathologic findings in a rare aggressive primary bone or soft tissue tumor. Am. J. Surg. Pathol. 2019; 43; 1112-1122.
Genecards-the human gene database (database online). NFATC4 gene. 2023. Available at: https://www.genecards.org/cgi-bin/carddisp.pl?gene=NFATC4#paralogs.
Zhong Q-H, Zha S-W, Lau ATY, Xu Y-M. Recent knowledge of NFATc4 in oncogenesis and cancer prognosis. Cancer Cell Int. 2022; 22; 212.
