As COVID-19 is spreading, national agencies need to monitor and track several metrics. Since we do not have perfect testing programs on the hand, one needs to develop an advanced sampling strategies for prevalence study, control and management. Here we introduce REDACS: Regional emergency-driven adaptive cluster sampling for effective COVID-19 management and control and justify its usage for COVID-19. We show its advantages over classical massive individual testing sampling plans. We also point out how regional and spatial heterogeneity underlines proper sampling. Fundamental importance of adaptive control parameters from emergency health stations and medical frontline is outlined. Since the Northern hemisphere entered Autumn and Winter season (this paper was originally submitted in November 2020), practical illustration from spatial heterogeneity of Chile (Southern hemisphere, which already experienced COVID-19 winter outbreak peak) is underlying the importance of proper regional heterogeneity of sampling plan. We explain the regional heterogeneity by microbiological backgrounds and link it to behavior of Lyapunov exponents. We also discuss screening by antigen tests from the perspective of "on the fly" biomarker validation, i.e., during the screening.

Biostatistics Program School of Public Health University of Chile Santiago Chile

Centro de Micro Bioinnovación Escuela de Nutrición y Dietética Facultad de Farmacia Universidad de Valparaíso Valparaíso Chile

Departamento de Estomatología Facultad de Ciencias de la Salud Universidad de Talca Chile

Department of Biomedical Data Science School of Medicine Stanford University Stanford California USA

Emeritus Prof STU Senior Konzulting ESK

Facultad de Ingeniería Universidad Andrés Bello Valparaíso Chile

Institute of Epidemiology Faculty of Medicine in Bratislava Comenius University Slovak Republic

Institute of Mathematics Faculty of Science P J Šafárik University Košice Slovakia

Instituto de Estadística Universidad de Valparaíso Valparaíso Chile

Instituto de Fomento Pesquero Chile

Linz Institute of Technology and Department of Applied Statistics J Kepler University in Linz Linz Austria

The University of Iowa Iowa City Iowa USA

University of Pardubice Pardubice Czech Republic

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