Site-selective peptide functionalisation mediated via vinyl-triazine linchpins
Language English Country England, Great Britain Media electronic
Document type Journal Article
PubMed
38108130
DOI
10.1039/d3cc05213c
Knihovny.cz E-resources
- MeSH
- Alkynes MeSH
- Cycloaddition Reaction MeSH
- Electrons MeSH
- Peptides * MeSH
- Triazines * MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alkynes MeSH
- Peptides * MeSH
- Triazines * MeSH
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective bioconjugation of biologically relevant peptides, followed by rapid and highly selective reactions with bicyclononyne (BCN) reagents.
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