Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't
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PubMed
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PubMed Central
PMC11153161
DOI
10.1038/s41380-023-02352-0
PII: 10.1038/s41380-023-02352-0
Knihovny.cz E-resources
- MeSH
- White Matter pathology diagnostic imaging MeSH
- Deep Learning MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging * methods MeSH
- Cerebellum * pathology diagnostic imaging MeSH
- Stress Disorders, Post-Traumatic * pathology physiopathology diagnostic imaging MeSH
- Gray Matter pathology MeSH
- Organ Size MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p-FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.
Amsterdam UMC University of Amsterdam Psychiatry Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC Vrije Universiteit Psychiatry Amsterdam Neuroscience Amsterdam The Netherlands
ARQ National Psychotrauma Centre Diemen The Netherlands
Brain Health Research Centre Department of Anatomy University of Otago Dunedin New Zealand
Brain Imaging and Analysis Center Duke University Durham NC USA
Center for Behavior Genetics of Aging University of California San Diego La Jolla CA USA
Center for Brain and Behavior Research University of South Dakota Vermillion SD USA
Center for Depression Anxiety and Stress Research McLean Hospital Harvard University Belmont MA USA
Center for Global Health Equity New York University Shanghai Shanghai China
Center for Healthy Minds University of Wisconsin Madison Madison WI USA
CIC1415 CHRU de Tours Inserm Tours France
Civil Aerospace Medical Institute US Federal Aviation Administration Oklahoma City OK USA
Comprehensive Injury Center Medical College of Wisconsin Milwaukee WI USA
Department of Clinical Psychology University of Groningen Groningen The Netherlands
Department of Experimental Clinical and Health Psychology Ghent University Ghent Belgium
Department of Neurology University of Utah School of Medicine Salt Lake City UT USA
Department of Neuroscience Central Clinical School Monash University Melbourne Vic Australia
Department of Neuroscience University of Rochester Medical Center Rochester NY USA
Department of Neurosciences University of Toledo Toledo OH USA
Department of Pediatrics University of Minnesota Minneapolis MN USA
Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Richmond VA USA
Department of Psychiatry and Behavioral Sciences Duke School of Medicine Durham NC USA
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta GA USA
Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USA
Department of Psychiatry and Behavioral Sciences University of Minnesota Minneapolis MN USA
Department of Psychiatry Baylor College of Medicine Houston TX USA
Department of Psychiatry Columbia University Medical Center New York NY USA
Department of Psychiatry Erasmus University Medical Center Rotterdam the Netherlands
Department of Psychiatry Harvard Medical School Boston MA USA
Department of Psychiatry Stellenbosch University Cape Town South Africa
Department of Psychiatry Texas A and M University Bryan Texas USA
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry University of Michigan Ann Arbor MI USA
Department of Psychiatry University of Texas at Austin Austin TX USA
Department of Psychiatry University of Toledo Toledo OH USA
Department of Psychiatry University of Wisconsin Madison Madison WI USA
Department of Psychiatry Yale University School of Medicine New Haven CT USA
Department of Psychology and Neuroscience Baylor University Waco TX USA
Department of Psychology Marquette University Milwaukee WI USA
Department of Psychology The Education University of Hong Kong Ting Kok Hong Kong
Department of Psychology University of Chinese Academy of Sciences Beijing China
Department of Psychology University of Minnesota Minneapolis MN USA
Department of Psychology University of South Dakota Vermillion SD USA
Department of Psychology University of Wisconsin Madison Madison WI USA
Department of Psychology University of Wisconsin Milwaukee Milwaukee WI USA
Department of Psychology Vanderbilt University Nashville TN USA
Department of Radiology Washington University School of Medicine St Louis MO USA
Departments of Psychiatry and of Psychology Wu Tsai Institute Yale University New Haven CT USA
Departments of Radiology Psychiatry and Biomedical Engineering University of Iowa Iowa City IA USA
Dept of Psychological and Brain Sciences Boston University Boston MA USA
Disaster Mental Health Institute Vermillion SD USA
Division of Clinical Neuroscience National Center for PTSD West Haven CT USA
Division of Depression and Anxiety Disorders McLean Hospital Belmont MA USA
Division of Women's Mental Health McLean Hospital Belmont MA USA
George E Wahlen Veterans Affairs Medical Center Salt Lake City UT USA
Institute for Technology in Psychiatry McLean Hospital Belmont MA USA
Institute of Medical Psychology and Systems Neuroscience University of Münster Münster Germany
Masonic Institute for the Developing Brain Minneapolis MN USA
Minneapolis VA Health Care System Minneapolis MN USA
Monash Biomedical Imaging Monash University Melbourne Vic Australia
Munroe Meyer Institute University of Nebraska Medical Center Omaha NE USA
Neuroscience Research Australia Randwick NSW Australia
New York State Psychiatric Institute New York NY USA
School of Medicine and Public Health University of Wisconsin Madison Madison WI USA
School of Psychology University of New South Wales Sydney Sydney NSW Australia
Sioux Falls VA Health Care System Sioux Falls SD USA
Tel Aviv University Tel Aviv Yafo Israel
UMR1253 Université de Tours Inserm Tours France
University Medical Centre Charité Berlin Germany
University of Haifa Haifa Israel
VA Palo Alto Health Care System Palo Alto CA USA
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