In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs
Language English Country Ireland Media print-electronic
Document type Journal Article
PubMed
38237451
DOI
10.1016/j.cmpb.2024.108016
PII: S0169-2607(24)00012-9
Knihovny.cz E-resources
- Keywords
- Antihypertensives, Atherosclerosis, Carotid artery, Multiscale flow simulations, Parameter optimization, Patient-specific model,
- MeSH
- Pulse Wave Analysis MeSH
- Antihypertensive Agents * pharmacology MeSH
- Carotid Arteries MeSH
- Atherosclerosis * drug therapy MeSH
- Hemodynamics physiology MeSH
- Humans MeSH
- Models, Cardiovascular MeSH
- Computer Simulation MeSH
- Blood Flow Velocity MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antihypertensive Agents * MeSH
BACKGROUND AND OBJECTIVES: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. METHODS: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. RESULTS: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of area-averaged TAWSS related to the old flow waveform is much more pronounced (2.5 ÷ 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. CONCLUSIONS: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.
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