Isolation and Bioactivity Evaluation of Sesquiterpenes from an Alcyonarian of the Genus Lemnalia from the Saudi Arabian Red Sea
Language English Country Switzerland Media print-electronic
Document type Journal Article
Grant support
OSR-2017-CPF-3627-2
Subaward Agreement
King Abdullah University of Science and Technology
Z.02.1.01/0.0/0.0/16_019/0000868
European Regional Developmental
23-05474S
Czech Grant Agency
- Keywords
- Lemnalia, androgen receptor-regulated transcription, anti-inflammatory activity, neuroprotective activity, sesquiterpenes,
- MeSH
- Anthozoa * chemistry MeSH
- Humans MeSH
- Antineoplastic Agents * pharmacology metabolism MeSH
- Sesquiterpenes * chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Indian Ocean MeSH
- Saudi Arabia MeSH
- Names of Substances
- Antineoplastic Agents * MeSH
- Sesquiterpenes * MeSH
Over the last decades, soft corals have been proven a rich source of biologically active compounds, featuring a wide range of chemical structures. Herein, we investigated the chemistry of an alcyonarian of the genus Lemnalia (Neptheidae), specimens of which were collected from the coral reefs near Al Lith, on the south-west coast of Saudi Arabia. A series of chromatographic separations led to the isolation of 31 sesquiterpenes, featuring mainly the nardosinane and neolemnane carbon skeletons, among which three (13, 14 and 28) are new natural products. The metabolites isolated in sufficient amounts were evaluated in vitro in human tumor and non-cancerous cell lines for a number of biological activities, including their cytotoxic, anti-inflammatory, anti-angiogenic, and neuroprotective activities, as well as for their effect on androgen receptor (AR)-regulated transcription. Among the tested metabolites, compound 12 showed comparable neuroprotective activity to the positive control N-acetylcysteine, albeit at a 10-fold lower concentration.
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