• This record comes from PubMed

Comparison between postcontrast thin-slice T1-weighted 2D spin echo and 3D T1-weighted SPACE sequences in the detection of brain metastases at 1.5 and 3 T

. 2024 Mar 14 ; 15 (1) : 73. [epub] 20240314

Status PubMed-not-MEDLINE Language English Country Germany Media electronic

Document type Journal Article

Grant support
IG204301 Ministerstvo Zdravotnictví Ceské Republiky
IG204302 Ministerstvo Zdravotnictví Ceské Republiky
IG204303 Ministerstvo Zdravotnictví Ceské Republiky

Links

PubMed 38483648
PubMed Central PMC10940548
DOI 10.1186/s13244-024-01643-6
PII: 10.1186/s13244-024-01643-6
Knihovny.cz E-resources

OBJECTIVES: Accurate detection of metastatic brain lesions (MBL) is critical due to advances in radiosurgery. We compared the results of three readers in detecting MBL using T1-weighted 2D spin echo (SE) and sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) sequences with whole-brain coverage at both 1.5 T and 3 T. METHODS: Fifty-six patients evaluated for MBL were included and underwent a standard protocol (1.5 T, n = 37; 3 T, n = 19), including postcontrast T1-weighted SE and SPACE. The rating was performed by three raters in two sessions > six weeks apart. The true number of MBL was determined using all available imaging including follow-up. Intraclass correlations for intra-rater and inter-rater agreement were calculated. Signal intensity ratios (SIR; enhancing lesion, white matter) were determined on a subset of 46 MBL > 4 mm. A paired t-test was used to evaluate postcontrast sequence order and SIR. Reader accuracy was evaluated by the coefficient of determination. RESULTS: A total of 135 MBL were identified (mean/subject 2.41, SD 6.4). The intra-rater agreement was excellent for all 3 raters (ICC = 0.97-0.992), as was the inter-rater agreement (ICC = 0.995 SE, 0.99 SPACE). Subjective qualitative ratings were lower for SE images; however, signal intensity ratios were higher in SE sequences. Accuracy was high in all readers for both SE (R2 0.95-0.96) and SPACE (R2 0.91-0.96) sequences. CONCLUSIONS: Although SE sequences are superior to gradient echo sequences in the detection of small MBL, they have long acquisition times and frequent artifacts. We show that T1-weighted SPACE is not inferior to standard thin-slice SE sequences in the detection of MBL at both imaging fields. CRITICAL RELEVANCE STATEMENT: Our results show the suitability of 3D T1-weighted turbo spin echo (TSE) sequences (SPACE, CUBE, VISTA) in the detection of brain metastases at both 1.5 T and 3 T. KEY POINTS: • Accurate detection of brain metastases is critical due to advances in radiosurgery. • T1-weighted SE sequences are superior to gradient echo in detecting small metastases. • T1-weighted 3D-TSE sequences may achieve high resolution and relative insensitivity to artifacts. • T1-weighted 3D-TSE sequences have been recommended in imaging brain metastases at 3 T. • We found T1-weighted 3D-TSE equivalent to thin-slice SE at 1.5 T and 3 T.

See more in PubMed

Fink KR, Fink JR. Imaging of brain metastases. Surg Neurol Int. 2013;4:S209–S219. doi: 10.4103/2152-7806.111298. PubMed DOI PMC

Patel TR, McHugh BJ, Bi WL, et al. A comprehensive review of MR imaging changes following radiosurgery to 500 brain metastases. AJNR Am J Neuroradiol. 2011;32:1885–1892. doi: 10.3174/ajnr.A2668. PubMed DOI PMC

Subedi K, Takahashi T, Yamano T, et al (2012) Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: A dose comparison study. J Radiat Res 54. 10.1093/jrr/rrs053 PubMed PMC

Seidl Z, Vymazal J, Mechl M et al (2012) Does higher gadolinium concentration play a role in the morphologic assessment of brain tumors? Results of a multicenter intraindividual crossover comparison of gadobutrol versus gadobenate dimeglumine (the MERIT study). AJNR Am J Neuroradiol. 10.3174/ajnr.A3033 PubMed PMC

Anzalone N, Gerevini S, Scotti R, et al. Detection of cerebral metastases on magnetic resonance imaging: intraindividual comparison of gadobutrol with gadopentetate dimeglumine. Acta Radiol. 2009;50:933–940. doi: 10.1080/02841850903095385. PubMed DOI

Wb POPE. Brain metastases: neuroimaging. Handb Clin Neurol. 2018;149:89–112. doi: 10.1016/B978-0-12-811161-1.00007-4. PubMed DOI PMC

Chappell PM, Pelc NJ, Foo TK, et al. Comparison of lesion enhancement on spin-echo and gradient-echo images. AJNR Am J Neuroradiol. 1994;15:37–44. PubMed PMC

Mugler JP, III, Brookeman JR. Theoretical analysis of gadopentetate dimeglumine enhancement in T1-weighted imaging of the brain: comparison of two-dimensional spin-echo and three-dimensional gradient-echo sequences. J Magn Reson Imaging. 1993;3:761–769. doi: 10.1002/jmri.1880030512. PubMed DOI

Suh CH, Jung S, Kim K, Pyo J (2016) The detectability of brain metastases using contrast-enhanced spin-echo or gradient-echo images: a systematic review and meta-analysis. J Neurooncol 129. 10.1007/s11060-016-2185-y PubMed

Kutuk T, Abrams KJ, Tom MC, et al. Dedicated isotropic 3-D T1 SPACE sequence imaging for radiosurgery planning improves brain metastases detection and reduces the risk of intracranial relapse. Radiother Oncol. 2022;173:84–92. doi: 10.1016/j.radonc.2022.05.029. PubMed DOI

Thrower SL, Al Feghali KA, Luo D, et al. The effect of slice thickness on contours of brain metastases for stereotactic radiosurgery. Adv Radiat Oncol. 2021;6:100708. doi: 10.1016/j.adro.2021.100708. PubMed DOI PMC

Kaufmann TJ, Smits M, Boxerman J, et al. Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases. Neuro Oncol. 2020;22:757–772. doi: 10.1093/neuonc/noaa030. PubMed DOI PMC

Kakeda S, Korogi Y, Hiai Y, et al. Detection of brain metastasis at 3T: comparison among SE, IR-FSE and 3D-GRE sequences. Eur Radiol. 2007;17:2345–2351. doi: 10.1007/s00330-007-0599-9. PubMed DOI

Komada T, Naganawa S, Ogawa H, et al. Contrast-enhanced MR imaging of metastatic brain tumor at 3 Tesla: utility of T1-weighted SPACE compared with 2D spin echo and 3D gradient echo sequence. Magn Reson Med Scie. 2008;7:13–21. doi: 10.2463/mrms.7.13. PubMed DOI

R Core Team R Core Team (2021) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/

Vymazal J, Hajek M, Patronas N, et al. The quantitative relation between T1-weighted and T2-weighted MRI of normal gray matter and iron concentration. J Magn Reson Imaging. 1995;5:554–560. doi: 10.1002/jmri.1880050514. PubMed DOI

Hendricks BK, DiDomenico JD, Barani IJ, Barranco FD. ZAP-X gyroscopic radiosurgery system: a preliminary analysis of clinical applications within a retrospective case series. Stereotact Funct Neurosurg. 2022;100:99–107. doi: 10.1159/000519862. PubMed DOI

Busse RF, Brau ACS, Vu A, et al. Effects of refocusing flip angle modulation and view ordering in 3D fast spin echo. Magn Reson Med. 2008;60:640–649. doi: 10.1002/mrm.21680. PubMed DOI PMC

Furutani K, Harada M, Mawlan M, Nishitani H. Difference in enhancement between spin echo and 3-dimensional fast spoiled gradient recalled acquisition in steady state magnetic resonance imaging of brain metastasis at 3-T magnetic resonance imaging. J Comput Assist Tomogr. 2008;32:313–319. doi: 10.1097/RCT.0b013e318074fd9d. PubMed DOI

Park J, Kim J, Yoo E, et al. Detection of small metastatic brain tumors: comparison of 3D contrast-enhanced whole-brain black-blood imaging and MP-RAGE imaging. Invest Radiol. 2012;47:136. doi: 10.1097/RLI.0b013e3182319704. PubMed DOI

Nobauer-Huhmann IM, Ba-Ssalamah A, Mlynarik V, et al. Magnetic resonance imaging contrast enhancement of brain tumors at 3 Tesla versus 1.5 Tesla. Invest Radiol. 2002;37:114–119. doi: 10.1097/00004424-200203000-00003. PubMed DOI

Poulen G, Chan Seng E, Menjot De Champfleur N, et al. Comparison between 1.5- and 3-T magnetic resonance acquisitions for direct targeting stereotactic procedures for deep brain stimulation: a phantom study. Stereotact Funct Neurosurg. 2020;98:337–344. doi: 10.1159/000509303. PubMed DOI

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...