Medical-Grade Honey Is a Versatile Wound Care Product for the Elderly

. 2024 ; 13 () : 51-59. [epub] 20240517

Status PubMed-not-MEDLINE Jazyk angličtina Země Spojené státy americké Médium electronic-ecollection

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid38774269

INTRODUCTION: Ageing of the global population has led to an increase in the demand for the treatment of wounds, especially considering the challenges of managing wounds in the elderly. Therefore, more effective treatment strategies need to be explored. In this article, we aimed to compare medical-grade honey (MGH) products with other wound care products and to provide guidelines on using MGH in wounds commonly found in the elderly. METHODS: Based on literature research and expert opinion, an overview of commonly used wound care products and their wound healing characteristics is provided. In addition, literature-based classification of wounds in the elderly and the recommendations for treatments are provided. RESULTS: Frequently used wound care products include povidone-iodine, enzymatic products, absorbing dressings, larvae, silver dressings, and MGH dressings. Supported by systematic reviews and meta-analyses, MGH dressings were identified as the most potent and all-round wound care product compared to the others. Next, we provided basic guidelines for managing the most common wounds in the elderly, both acute and chronic, and specified how and which MGH products can be used in these wounds. CONCLUSION: MGH is a widely applicable, safe, easy-to-use, and cost-effective product to manage wounds in the elderly. In case of doubt, refer to a trained wound care specialist who can support the treatment of difficult-to-heal wounds.

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Organization WH. Ageing and health 2022. [Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.

Strunk BC, Ginsburg PB, Banker MI. The effect of population aging on future hospital demand. Health Aff (Millwood). 2006;25(3):w141-9. doi: 10.1377/hlthaff.25.w141. PubMed DOI

Tapiwa Chamanga E. Clinical management of non-healing wounds. Nurs Stand. 2018;32(29):48-63. doi: 10.7748/ns.2018.e10829. PubMed DOI

Alam W, Hasson J, Reed M. Clinical approach to chronic wound management in older adults. J Am Geriatr Soc. 2021;69(8):2327-34. doi: 10.1111/jgs.17177. PubMed DOI

Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, et al. Chronic wound repair and healing in older adults: current status and future research. J Am Geriatr Soc. 2015;63(3):427-38. doi: 10.1111/jgs.13332. PubMed DOI PMC

Pleeging CCF, Wagener F, de Rooster H, Cremers NAJ. Revolutionizing non-conventional wound healing using honey by simultaneously targeting multiple molecular mechanisms. Drug Resist Updat. 2022;62:100834. doi: 10.1016/j.drup.2022.100834. PubMed DOI

Schilrreff P, Alexiev U. Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment. Int J Mol Sci. 2022;23(9) doi: 10.3390/ijms23094928. PubMed DOI PMC

Shin JW, Kwon SH, Choi JY, Na JI, Huh CH, Choi HR, et al. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019;20(9) doi: 10.3390/ijms20092126. PubMed DOI PMC

Farage MA, Miller KW, Elsner P, Maibach HI. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol. 2007;26(4):343-57. doi: 10.1080/15569520701622951. PubMed DOI

Werner H, Kuntsche J. [Infection in the elderly--what is different?]. Z Gerontol Geriatr. 2000;33(5):350-6. doi: 10.1007/s003910070031. PubMed DOI

Zumla A, Lulat A. Honey--a remedy rediscovered. JR Soc Med. 1989;82(7):384-5. doi: 10.1177/014107688908200704. PubMed DOI PMC

Ali FR, Fox J, Finlayson AE. Hippocrates on ulcers. JAMA Dermatol. 2013;149(9):1049. doi: 10.1001/jamadermatol.2013.4779. PubMed DOI

Forrest RD. Early history of wound treatment. JR Soc Med. 1982;75(3):198-205. doi: 10.1177/014107688207500310. PubMed DOI PMC

Combarros-Fuertes P, Fresno JM, Estevinho MM, Sousa-Pimenta M, Tornadijo ME, Estevinho LM. Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria? Antibiotics (Basel). 2020;9(11) doi: 10.3390/antibiotics9110774. PubMed DOI PMC

Cremers NA. Something old, something new: does medical grade honey target multidrug resistance? J Wound Care. 2021;30(3):160-1. doi: 10.12968/jowc.2021.30.3.160. PubMed DOI

Maddocks SE, Jenkins RE. Honey: a sweet solution to the growing problem of antimicrobial resistance? Future Microbiology. 2013;8(11):1419-29. doi: 10.2217/fmb.13.105. PubMed DOI

Nolan VC, Harrison J, Wright JEE, Cox JAG. Clinical Significance of Manuka and Medical-Grade Honey for Antibiotic-Resistant Infections: A Systematic Review. Antibiotics (Basel). 2020;9(11) doi: 10.3390/antibiotics9110766. PubMed DOI PMC

Hewett SR, Crabtrey SD, Dodson EE, Rieth CA, Tarkka RM, Naylor K. Both Manuka and Non-Manuka Honey Types Inhibit Antibiotic Resistant Wound-Infecting Bacteria. Antibiotics (Basel). 2022;11(8) doi: 10.3390/antibiotics11081132. PubMed DOI PMC

Mandal MD, Mandal S. Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154-60. doi: 10.1016/S2221-1691(11)60016-6. PubMed DOI PMC

Pleeging CCF, Coenye T, Mossialos D, de Rooster H, Chrysostomou D, Wagener F, et al. Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication. Antibiotics (Basel). 2020;9(12) doi: 10.3390/antibiotics9120866. PubMed DOI PMC

Bucekova M, Bugarova V, Godocikova J, Majtan J. Demanding new honey qualitative standard based on antibacterial activity. Foods. 2020;9(9):1263. doi: 10.3390/foods9091263. PubMed DOI PMC

Hermanns R, Mateescu C, Thrasyvoulou A, Tananaki C, Wagener FADTG, Cremers NAJ. Defining the standards for medical grade honey. Journal of Apicultural Research. 2020;59(2):125-35. doi: 10.1080/00218839.2019.1693713. DOI

Zammit Young GW, Blundell R. A review on the phytochemical composition and health applications of honey. Heliyon. 2023;9(2):e12507. doi: 10.1016/j.heliyon.2022.e12507. PubMed DOI PMC

Watts R, Frehner E. Evidence summary: Wound management: Medical-grade honey. Wound Practice & Research: Journal of the Australian Wound Management Association. 2017;25(2):117-20. https://search.informit.com.au/fullText;dn=021202765517428;res=IELHEA.

Rezvani Ghomi E, Khalili S, Nouri Khorasani S, Esmaeely Neisiany R, Ramakrishna S. Wound dressings: Current advances and future directions. Journal of Applied Polymer Science. 2019;136(27):47738. doi: 10.1002/app.47738. DOI

Dhivya S, Padma VV, Santhini E. Wound dressings - a review. Biomedicine (Taipei). 2015;5(4):22. doi: 10.7603/s40681-015-0022-9. PubMed DOI PMC

Jones V, Grey JE, Harding KG. Wound dressings. BMJ. 2006;332(7544):777-80. doi: 10.1136/bmj.332.7544.777. PubMed DOI PMC

Lepelletier D, Maillard JY, Pozzetto B, Simon A. Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization. Antimicrob Agents Chemother. 2020;64(9) doi: 10.1128/AAC.00682-20. PubMed DOI PMC

Durani P, Leaper D. Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation. Int Wound J. 2008;5(3):376-87. doi: 10.1111/j.1742-481X.2007.00405.x. PubMed DOI PMC

Ortega-Llamas L, Quinones-Vico MI, Garcia-Valdivia M, Fernandez-Gonzalez A, Ubago-Rodriguez A, Sanabria-de la Torre R, et al. Cytotoxicity and Wound Closure Evaluation in Skin Cell Lines after Treatment with Common Antiseptics for Clinical Use. Cells. 2022;11(9) doi: 10.3390/cells11091395. PubMed DOI PMC

Isabela Avila-Rodriguez M, Melendez-Martinez D, Licona-Cassani C, Manuel Aguilar-Yanez J, Benavides J, Lorena Sanchez M. Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review). Biomed Rep. 2020;13(1):3-14. doi: 10.3892/br.2020.1300. PubMed DOI PMC

Sharaf A, Muthayya P. Microbial profile of burn wounds managed with enzymatic debridement using bromelain-based agent, NexoBrid(R). Burns. 2022;48(7):1618-25. doi: 10.1016/j.burns.2021.12.004. PubMed DOI

Winter GD. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293-4. doi: 10.1038/193293a0. PubMed DOI

Jones ML. An introduction to absorbent dressings. Br J Community Nurs. 2014;Suppl Wound Care:S28-30. doi: 10.12968/bjcn.2014.19.Sup12.S28. PubMed DOI

Tamura T, Cazander G, Rooijakkers SH, Trouw LA, Nibbering PH. Excretions/ secretions from medicinal larvae (Lucilia sericata) inhibit complement activation by two mechanisms. Wound Repair Regen. 2017;25(1):41-50. doi: 10.1111/wrr.12504. PubMed DOI

van der Plas MJ, Baldry M, van Dissel JT, Jukema GN, Nibbering PH. Maggot secretions suppress pro-inflammatory responses of human monocytes through elevation of cyclic AMP. Diabetologia. 2009;52(9):1962-70. doi: 10.1007/s00125-009-1432-6. PubMed DOI PMC

Fonseca-Munoz A, Sarmiento-Jimenez HE, Perez-Pacheco R, Thyssen PJ, Sherman RA. Clinical study of Maggot therapy for Fournier’s gangrene. Int Wound J. 2020;17(6):1642-9. doi: 10.1111/iwj.13444. PubMed DOI PMC

Kedziora A, Speruda M, Krzyzewska E, Rybka J, Lukowiak A, Bugla-Ploskonska G. Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents. Int J Mol Sci. 2018;19(2) doi: 10.3390/ijms19020444. PubMed DOI PMC

Khansa I, Schoenbrunner AR, Kraft CT, Janis JE. Silver in Wound Care-Friend or Foe?: A Comprehensive Review. Plast Reconstr Surg Glob Open. 2019;7(8):e2390. doi: 10.1097/GOX.0000000000002390. PubMed DOI PMC

Kwakman PH, Te Velde AA, de Boer L, Vandenbroucke-Grauls CM, Zaat SA. Two major medicinal honeys have different mechanisms of bactericidal activity. PLoS One. 2011;6(3):e17709. doi: 10.1371/journal.pone.0017709. PubMed DOI PMC

Holubova A, Chlupacova L, Cetlova L, Cremers NAJ, Pokorna A. Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series. Antibiotics (Basel). 2021;10(8) doi: 10.3390/antibiotics10080918. PubMed DOI PMC

Naik PP, Chrysostomou D, Cinteza M, Pokorna A, Cremers NA. When time does not heal all wounds-the use of medical grade honey in wound healing: a case series. J Wound Care. 2022;31(7):548-58. doi: 10.12968/jowc.2022.31.7.548. PubMed DOI

Papanikolaou GE, Gousios G, Cremers NAJ. Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series. Antibiotics (Basel). 2023;12(605) doi: 10.3390/antibiotics12030605. PubMed DOI PMC

Aziz Z, Abdul Rasool Hassan B. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns. 2017;43(1):50-7. doi: 10.1016/j.burns.2016.07.004. PubMed DOI

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PubMed DOI PMC

McLoone P, Tabys D, Fyfe L. Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature. Clin Cosmet Investig Dermatol. 2020;13:875-88. doi: 10.2147/CCID.S282143. PubMed DOI PMC

Wang C, Guo M, Zhang N, Wang G. Effectiveness of honey dressing in the treatment of diabetic foot ulcers: A systematic review and meta-analysis. Complement Ther Clin Pract. 2019;34:123-31. doi: 10.1016/j.ctcp.2018.09.004. PubMed DOI

Yilmaz AC, Aygin D. Honey Dressing in Wound Treatment: A Systematic Review. Complement Ther Med. 2020;51:102388. doi: 10.1016/j.ctim.2020.102388. PubMed DOI

Oryan A, Alemzadeh E, Moshiri A. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. Journal of tissue viability. 2016;25(2):98-118. doi: 10.1016/j.jtv.2015.12.002. PubMed DOI

Zhang F, Chen Z, Su F, Zhang T. Comparison of topical honey and povidone iodine-based dressings for wound healing: a systematic review and meta-analysis. J Wound Care. 2021;30(Sup4):S28-S36. doi: 10.12968/jowc.2021.30.Sup4.S28. PubMed DOI

de Groot T, Janssen T, Faro D, Cremers NAJ, Chowdhary A, Meis JF. Antifungal Activity of a Medical-Grade Honey Formulation against Candida auris. J Fungi (Basel). 2021;7(1) doi: 10.3390/jof7010050. PubMed DOI PMC

Majtan J, Sojka M, Palenikova H, Bucekova M, Majtan V. Vitamin C Enhances the Antibacterial Activity of Honey against Planktonic and Biofilm-Embedded Bacteria. Molecules. 2020;25(4) doi: 10.3390/molecules25040992. PubMed DOI PMC

Oliveira AMP, Devesa JSP, Hill PB. In vitro efficacy of a honey-based gel against canine clinical isolates of Staphylococcus pseudintermedius and Malassezia pachydermatis. Vet Dermatol. 2018;29(3):180-e65. doi: 10.1111/vde.12533. PubMed DOI

Pleeging CCF, Coenye T, Mossialos D, De Rooster H, Chrysostomou D, Wagener FADTG, et al. Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication. Antibiotics 2020;9(12):866. doi: doi:10.3390/antibiotics9120866. PubMed DOI PMC

Van Tiggelen H, LeBlanc K, Campbell K, Woo K, Baranoski S, Chang YY, et al. Standardizing the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel Classification System in 44 countries. Br J Dermatol. 2020;183(1):146-54. doi: 10.1111/bjd.18604. PubMed DOI PMC

Ortega G, Rhee DS, Papandria DJ, Yang J, Ibrahim AM, Shore AD, et al. An evaluation of surgical site infections by wound classification system using the ACS-NSQIP. J Surg Res. 2012;174(1):33-8. doi: 10.1016/j.jss.2011.05.056. PubMed DOI

Wagner FW, Jr. The dysvascular foot: a system for diagnosis and treatment. Foot Ankle. 1981;2(2):64-122. doi: 10.1177/107110078100200202. PubMed DOI

NPUAP, EPUAP, PPPIA. Prevention and Treatment of Pressure Ulcers: Quick Reference Guide. 2019.

Schulz V, Kozell K, Biondo PD, Stiles C, Martins L, Tonkin K, et al. The malignant wound assessment tool: a validation study using a Delphi approach. Palliat Med. 2009;23(3):266-73. doi: 10.1177/0269216309102536. PubMed DOI

Serra R, Ielapi N, Barbetta A, de Franciscis S. Skin tears and risk factors assessment: a systematic review on evidence-based medicine. Int Wound J. 2018;15(1):38-42. doi: 10.1111/iwj.12815. PubMed DOI PMC

Haynes SJ, Callaghan R. Properties of honey: its mode of action and clinical outcomes. Wounds UK. 2011;7(1):50-7. https://wounds-uk.com/journal-articles/properties-of-honey-its-mode-of-action-and-clinical-outcomes/.

Kegels F. Clinical evaluation of honey-based products for lower extremity wounds in a home care setting. Wounds UK. 2011;7(2):46-53. https://wounds-uk.com/journal-articles/clinical-evaluation-of-honey-based-products-for-lower-extremity-wounds-in-a-home-care-setting/.

Berian JR, Rosenthal RA, Baker TL, Coleman J, Finlayson E, Katlic MR, et al. Hospital Standards to Promote Optimal Surgical Care of the Older Adult: A Report From the Coalition for Quality in Geriatric Surgery. Ann Surg. 2018;267(2):280-90. doi: 10.1097/SLA.0000000000002185. PubMed DOI

Piednoir E, Robert-Yap J, Baillet P, Lermite E, Christou N. The Socioeconomic Impact of Surgical Site Infections. Front Public Health. 2021;9:712461. doi: 10.3389/fpubh.2021.712461. PubMed DOI PMC

Smaropoulos E, Cremers NA. Medical grade honey for the treatment of paediatric abdominal wounds: a case series. J Wound Care. 2020;29(2):94-9. doi: 10.12968/jowc.2020.29.2.94. PubMed DOI

Smaropoulos E, Cremers NAJ. The pro-healing effects of medical grade honey supported by a pediatric case series. Complement Ther Med. 2019;45:14-8. doi: 10.1016/j.ctim.2019.05.014. PubMed DOI

Van der Merwe ZR. Advanced wound management of squamous cell carcinoma and systemic lupus erythematosus: case report. Wound Healing Southern Africa. 2020;13(2):52-4. https://journals.co.za/doi/abs/10.10520/ejc-mp_whsa-v13-n2-a4 DOI

Zbuchea A. Honey, Food and Medicine: Scientific Rationale and Practical Efficiency in External Administration of Medicinal Honey for Wound Healing Journal of Agricultural Science and Technology B. 2017;7:206-19. doi: doi: 10.17265/2161-6264/2017.03.008 DOI

Bocoum A, Riel S, Traore SO, Ngo Oum Ii EF, Traore Y, Thera AT, et al. Medical-Grade Honey Enhances the Healing of Caesarean Section Wounds and Is Similarly Effective to Antibiotics Combined with Povidone-Iodine in the Prevention of Infections-A Prospective Cohort Study. Antibiotics (Basel). 2023;12(1) doi: 10.3390/antibiotics12010092. PubMed DOI PMC

Majid E, Pathan S, Zuberi BF, Rehman M, Malik S. Comparison of Honey & Povidone Iodine dressings in Post-Cesarean Surgical Site Wound Infection Healing. Pak J Med Sci. 2023;39(6):1803-8. doi: 10.12669/pjms.39.6.7499. PubMed DOI PMC

Goharshenasan P, Amini S, Atria A, Abtahi H, Khorasani G. Topical Application of Honey on Surgical Wounds: A Randomized Clinical Trial. Forsch Komplementmed. 2016;23(1):12-5. doi: 10.1159/000441994. PubMed DOI

London NJ, Donnelly R. ABC of arterial and venous disease. Ulcerated lower limb. BMJ. 2000;320(7249):1589-91. doi: 10.1136/bmj.320.7249.1589. PubMed DOI PMC

Vowden P, Vowden K. Doppler assessment and ABPI: interpretation in the management of leg ulceration. World Wide Wounds. 2001;18 http://www.worldwidewounds.com/2001/march/Vowden/Doppler-assessment-and-ABPI.html

Mthanti SM, Pelle G, Cremers NAJ. L-Mesitran Foam: Evaluation of a New Wound Care Product. Case Rep Dermatol Med. 2022;2022:4833409. doi: 10.1155/2022/4833409. PubMed DOI PMC

Vandeputtte J, Van Waeyenberge PH. Clinical evaluation of L-Mesitran. EWMA J 2003;3(2):8-11. http://www.pntonline.co.za/index.php/pnt/article/view/123

Dunford CE, Hanano R. Acceptability to patients of a honey dressing for non-healing venous leg ulcers. J Wound Care. 2004;13(5):193-7. doi: 10.12968/jowc.2004.13.5.26614. PubMed DOI

Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. New England Journal of Medicine. 2017;376(24):2367-75. doi: 10.1056/NEJMra1615439. PubMed DOI

Driver VR, Fabbi M, Lavery LA, Gibbons G. The costs of diabetic foot: the economic case for the limb salvage team. J Vasc Surg. 2010;52(3 Suppl):17S-22S. doi: 10.1016/j.jvs.2010.06.003. PubMed DOI

Dias A, Ferreira G, Vilaca M, Pereira MG. Quality of Life in Patients with Diabetic Foot Ulcers: A Cross-sectional Study. Adv Skin Wound Care. 2022;35(12):661-8. doi: 10.1097/01.ASW.0000891864.37619.34. PubMed DOI

Larsson J, Apelqvist J, Agardh CD, Stenstrom A. Decreasing incidence of major amputation in diabetic patients: a consequence of a multidisciplinary foot care team approach? Diabet Med. 1995;12(9):770-6. doi: 10.1111/j.1464-5491.1995.tb02078.x. PubMed DOI

Perez-Favila A, Martinez-Fierro ML, Rodriguez-Lazalde JG, Cid-Baez MA, Zamudio-Osuna MJ, Martinez-Blanco MDR, et al. Current Therapeutic Strategies in Diabetic Foot Ulcers. Medicina (Kaunas). 2019;55(11) doi: 10.3390/medicina55110714. PubMed DOI PMC

Yildiz Karadeniz E, Kaplan Serin E. Use of honey in diabetic foot ulcer: Systematic review and meta-analysis. J Tissue Viability. 2023;32(2):270-8. doi: 10.1016/j.jtv.2023.03.002. PubMed DOI

Holubová A, Chlupáčová L, Krocová J, Cetlová L, Peters LJF, Cremers NAJ, et al. The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study. Antibiotics. 2023;12(9) doi: 10.3390/antibiotics12091364. PubMed DOI PMC

Bergstrom N, Braden BJ, Laguzza A, Holman V. The Braden Scale for Predicting Pressure Sore Risk. Nurs Res. 1987;36(4):205-10. https://www.ncbi.nlm.nih.gov/pubmed/3299278. PubMed

Higgins J, Casey S, Taylor E, Wilson R, Halcomb P. Comparing the Braden and Jackson/Cubbin Pressure Injury Risk Scales in Trauma-Surgery ICU Patients. Crit Care Nurse. 2020;40(6):52-61. doi: 10.4037/ccn2020874. PubMed DOI

Yapucu Gunes U, Eser I. Effectiveness of a honey dressing for healing pressure ulcers. J Wound Ostomy Continence Nurs. 2007;34(2):184-90. doi: 10.1097/01.WON.0000264833.11108.35. PubMed DOI

Sankar J, Lalitha AV, Rameshkumar R, Mahadevan S, Kabra SK, Lodha R. Use of Honey Versus Standard Care for Hospital-Acquired Pressure Injury in Critically Ill Children: A Multicenter Randomized Controlled Trial. Pediatr Crit Care Med. 2021;22(6):e349-e62. doi: 10.1097/PCC.0000000000002611. PubMed DOI

Halim J, Dwimartutie N. Honey Accelerates Wound Healing in Pressure Ulcer: A Review. Jurnal Plastik Rekonstruksi. 2020;7(1):35-43. doi: 10.14228/jpr.v7i1.291. DOI

Starace M, Carpanese MA, Pampaloni F, Dika E, Pileri A, Rubino D, et al. Management of malignant cutaneous wounds in oncologic patients. Supportive Care in Cancer. 2022;30(9):7615-23. doi: 10.1007/s00520-022-07194-0. PubMed DOI PMC

Tsichlakidou A, Govina O, Vasilopoulos G, Kavga A, Vastardi M, Kalemikerakis I. Intervention for symptom management in patients with malignant fungating wounds - a systematic review. J BUON. 2019;24(3):1301-8. https://www.ncbi.nlm.nih.gov/pubmed/31424694. PubMed

Lund-Nielsen B, Adamsen L, Kolmos HJ, Rorth M, Tolver A, Gottrup F. The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study. Wound Repair Regen. 2011;19(6):664-70. doi: 10.1111/j.1524-475X.2011.00735.x. PubMed DOI

Drain J, Fleming MO. Palliative management of malodorous squamous cell carcinoma of the oral cavity with Manuka honey. J Wound Ostomy Continence Nurs. 2015;42(2):190-2. doi: 10.1097/WON.0000000000000114. PubMed DOI

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