INTRODUCTION: Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications. METHODS AND ANALYSIS: The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC. ETHICS AND DISSEMINATION: All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier: NCT05818644.

Centre for Liver and Biliary Sciences Max Super Speciality Hospital Saket New Delhi Delhi India

Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA

Department Clinical Interventions and Technology CLINTEC Division for Paediatrics Karolinska Institute Stockholm Sweden

Department Clinical Science Intervention and Technology CLINTEC Division for Interventional Radiology Karolinska Institute Stockholm Sweden

Department of Gastroenterology The Royal Children's Hospital Melbourne Melbourne Victoria Australia

Department of General Visceral and Transplant Surgery Hannover Medical School Hannover Germany

Department of Hepatobiliary and Pancreatic Surgery Liver Transplant Center Zhejiang University School of Medicine 1st Affiliated Hospital Hangzhou Zhejiang China

Department of Interventional Radiology Auckland City Hospital Auckland Auckland New Zealand

Department of Nuclear Medicine and Molecular Imaging Medical Imaging Center University Medical Centre Groningen Groningen The Netherlands

Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII Bergamo Italy

Department of Paediatric Gastroenterology Starship Children's Health Auckland New Zealand

Department of Paediatric Hepatology Gastroenterology and Transplantation ASST Papa Giovanni XXIII Bergamo Italy

Department of Paediatric Radiology Paris Saclay University AP HP Hôpital Bicêtre Le Kremlin Bicêtre France

Department of Paediatrics 1 Medical University of Innsbruck Innsbruck Austria

Department of Paediatrics Division of Paediatric Gastroenterology Hepatology and Nutrition University of Utah Primary Children's Hospital Salt Lake City Utah USA

Department of Paediatrics Hospital Santo Antonio Porto Alegre Brazil

Department of Paediatrics Hospital Santo Antonio Salvador Brazil

Department of Paediatrics National University Hospital Singapore

Department of Peadiatrics Wits Donald Gordon Medical Centre Johannesburg South Africa

Department of Pediatric Hepatology and Gastroenterology Amrita Institute of Medical Sciences and Research Centre New Delhi Delhi India

Department of Pediatric Surgery and Organ Transplantation Children's Memorial Health Institute Warszawa Poland

Department of Pediatrics 1st Faculty of Medicine Thomayer University Hospital Praha Czech Republic

Department of Radiology ASST Papa Giovanni XXIII Bergamo Italy

Department of Radiology Birmingham Women's and Children's Hospitals NHS Foundation Trust Birmingham UK

Department of Radiology Medical Imaging Center University Medical Centre Groningen Groningen The Netherlands

Department of Radiology The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

Department of Solid organ transplantation Amrita Institute of Medical Sciences and Research Centre Kochi Kerala India

Department of Surgery Division of Paediatric Surgery University of Utah Primary Children's Hospital Salt Lake City Utah USA

Department of Surgery Division of Transplantation Surgery University of Alberta Faculty of Medicine and Dentistry Edmonton Alberta Canada

Department of Surgery Section of Hepatobiliary Surgery and Liver Transplantation University Medical Centre Groningen Groningen The Netherlands

Department of surgery Wits Donald Gordon Medical Centre Johannesburg South Africa

Department of Transplant Surgery Institute of Clinical and Experimental medicine Praha Czech Republic

Department of Visceral Transplantation University Medical Center Hamburg Eppendorf Hamburg Germany

Division for Pediatric Gastroenterology and Hepatology Department of Pediatric Kidney Liver and Metabolic Diseases Hannover Medical School Hannover Germany

Division for Transplantation Surgery Department Clinical Interventions and Technology CLINTEC Karolinska Institute Stockholm Sweden

Division of Gastroenterology Hepatology and Nutrition Department of Paediatrics The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

Division of Hepatobiliopancreatic Surgery Liver and Kidney Transplantion Ospedale Pediatrico Bambino Gesu Roma Italy

Division of Interventional Radiology Hospital de Pediatría Prof Dr Juan P Garrahan Buenos Aires Argentina

Division of Liver Transplant Hospital de Pediatría Prof Dr Juan P Garrahan Buenos Aires Argentina

Division of Paediatric Gastroenterology and Hepatology Department of Paediatrics University Medical Centre Groningen Groningen The Netherlands

Division of Transplant and Advanced Hepatobiliary Surgery Ann and Robert H Lurie Children's Hospital of Chicago Chicago Illinois USA

Dr Rela Institute and Medical Centre Bharath Institute of Higher Education and Research Chennai Tamil Nadu India

Gastrointestinal and Transplanted Liver Imaging Unit Ospedale Pediatrico Bambino Gesù Roma Italy

Hepatology and Liver Transplant Unit Ospedale Pediatrico Bambino Gesu Roma Italy

Hepatology and Liver Transplantation Hospital Sírio Libanês Sao Paulo Brazil

HPB and Liver transplant unit Hospital Italiano de Buenos Aires Buenos Aires Argentina

Institute of Cell Biology Medical University of Innsbruck Innsbruck Austria

Integrated Liver Care Department Aster CMI Hospital Bengaluru Karnataka India

Intermountain Primary Children's Hospital Salt Lake City Utah USA

Liver Unit Birmingham Women's and Children's Hospitals NHS Foundation Trust Birmingham UK

National University Hospital Singapore

New Zealand Liver Transplant Unit Auckland City Hospital Auckland Auckland New Zealand

Northwestern University Feinberg School of Medicine Chicago Illinois USA

Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia

Organ Transplantation Center National Center for Child Health and Development Setagaya ku Japan

Organ Transplantation Centre National Center for Child Health and Development Hospital Tokyo Japan

Paediatric Gastroenterology and Hepatology University Hospitals Tubingen Tubingen Germany

Paediatric Hepatology and Paediatric Liver Transplantation Unit Paris Saclay University AP HP Hopital Bicetre Le Kremlin Bicêtre France

Paediatric Surgery and Paediatric Liver Transplantation Unit Paris Saclay University AP HP Hôpital Bicêtre Le Kremlin Bicêtre France

Pediatric Hepatology and Liver Trasplant Department Vall d'Hebron University Hospital Barcelona Spain

Pediatric Hepatology Department La Paz University Hospital Madrid Madrid Spain

Pediatric Surgery Department La Paz University Hospital Madrid Madrid Spain

Recanati Miller Transplantation Institute Mount Sinai Hospital Los Angeles California USA

School of Medicine and Surgery University of Milano Bicocca Milan Italy

Swiss Pediatric Liver Centre Division of Child and Adolescent Surgery Geneva University Hospitals Geneva Switzerland

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ClinicalTrials.gov
NCT05818644