Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application
Language English Country Germany Media print-electronic
Document type Journal Article, Review
PubMed
38870711
DOI
10.1016/j.prp.2024.155354
PII: S0344-0338(24)00265-6
Knihovny.cz E-resources
- Keywords
- Cancer therapy, Heterogeneity, Mesenchymal stem cells,
- MeSH
- Cell Differentiation physiology MeSH
- Humans MeSH
- Mesenchymal Stem Cells * MeSH
- Mesenchymal Stem Cell Transplantation * methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility. These advantages make hMSCs a promising tool in clinical application. However, the majority of clinical trials using hMSC therapy for diverse human diseases do not achieve expectations, despite the prospective pre-clinical outcomes in animal models. This is partly attributable to the intrinsic heterogeneity of hMSCs. In this review, the cause of heterogeneity in hMSCs is systematically discussed at multiple levels, including isolation methods, cultural conditions, donor-to-donor variation, tissue sources, intra-tissue subpopulations, etc. Additionally, the effect of hMSCs heterogeneity on the contrary role in tumor progression and immunomodulation is also discussed. The attempts to understand the cellular heterogeneity of hMSCs and its consequences are important in supporting and improving therapeutic strategies for hMSCs.
Changsha Medical University Changsha Hunan China
Department of Clinical Laboratory Xi'an International Medical Center Hospital Xi'an Shaanxi China
Department of Evolution Ecology and Behaviour University of Liverpool Liverpool UK
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