Silver-enriched microdomain patterns as advanced bactericidal coatings for polymer-based medical devices
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
38981327
DOI
10.1016/j.colsurfb.2024.114067
PII: S0927-7765(24)00326-6
Knihovny.cz E-zdroje
- Klíčová slova
- Antibacterial efficacy, Bioapplication, Laser-induced immobilization, Polyetheretherketone, Silver nanoparticles,
- MeSH
- antibakteriální látky * farmakologie chemie MeSH
- benzofenony * chemie farmakologie MeSH
- biokompatibilní potahované materiály chemie farmakologie MeSH
- Escherichia coli * účinky léků MeSH
- ketony chemie farmakologie MeSH
- kovové nanočástice * chemie MeSH
- lidé MeSH
- mikrobiální testy citlivosti * MeSH
- polyethylenglykoly * chemie farmakologie MeSH
- polymery * chemie farmakologie MeSH
- povrchové vlastnosti MeSH
- Staphylococcus aureus * účinky léků MeSH
- stříbro * chemie farmakologie MeSH
- velikost částic MeSH
- zdravotnické prostředky mikrobiologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky * MeSH
- benzofenony * MeSH
- biokompatibilní potahované materiály MeSH
- ketony MeSH
- polyetheretherketone MeSH Prohlížeč
- polyethylenglykoly * MeSH
- polymery * MeSH
- stříbro * MeSH
Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF excimer laser (λ=248 nm) on the polyetheretherketone (PEEK) surface that acts as an unfailing source of the antibacterial agent - silver. The hexagonal structure was formed with a grid placed in front of the incident laser beam. Surfaces with immobilized silver nanoparticles (AgNPs) were observed by AFM and SEM. Changes in surface chemistry were studied by XPS. To determine the concentration of released Ag+ ions, ICP-MS analysis was used. The antibacterial tests proved the antibacterial efficacy of Ag-doped PEEK composites against Escherichia coli and Staphylococcus aureus as the most common pathogens. Because AgNPs are also known for their strong toxicity, we also included cytotoxicity tests in this study. The findings presented here contribute to the advancement of materials design in the biomedical field, offering a novel starting point for combating bacterial infections through the innovative integration of AgNPs into inert synthetic polymers.
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