Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry
Language English Country United States Media print-electronic
Document type Journal Article, Multicenter Study
PubMed
39217551
DOI
10.1016/j.jacc.2024.05.076
PII: S0735-1097(24)07971-3
Knihovny.cz E-resources
- Keywords
- broken heart syndrome, stress cardiomyopathy, takotsubo syndrome, trends,
- MeSH
- Time Factors MeSH
- Middle Aged MeSH
- Humans MeSH
- Registries * MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Takotsubo Cardiomyopathy * epidemiology mortality diagnosis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND: The perception of takotsubo syndrome (TTS) has evolved significantly over the years, primarily driven by increased recognition of acute complications and mortality. OBJECTIVES: This study aimed to explore temporal trends in demographic patterns, risk factors, clinical presentations, and outcomes in patients with TTS. METHODS: Patients diagnosed with TTS between 2004 and 2021 were enrolled from the InterTAK (International Takotsubo) registry. To assess temporal trends, patients were divided into 6 groups, each corresponding to a 3-year interval within the study period. RESULTS: Overall, 3,957 patients were included in the study. There was a significant demographic transition, with the proportion of male patients rising from 10% to 15% (P = 0.003). Although apical TTS remained the most common form, the diagnosis of midventricular TTS increased from 18% to 28% (P = 0.018). The prevalence of physical triggers increased from 39% to 58% over the years (P < 0.001). There was a significant increase in 60-day mortality over the years (P < 0.001). However, a landmark analysis excluding patients who died within the first 60 days showed no differences in 1-year mortality (P = 0.150). CONCLUSIONS: This study of temporal trends in TTS highlights a transition in patients demographic with a growing prevalence among men, increasing recognition of midventricular TTS type, and increased short-term mortality and rates of cardiogenic shock in recent years. This transition aligns with the rising prevalence of physical triggers, as expression of increased recognition of TTS in association with acute comorbidities.
1st Department of Cardiology Medical University of Gdansk Gdansk Poland
Center for Cardiology Cardiology 1 University Medical Center Mainz Mainz Germany
Center for Molecular Cardiology Schlieren Campus University of Zurich Zurich Switzerland
Centro cardiologico Monzino IRCCS Milan Italy
Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany
Department of Cardiology and Angiology Hannover Medical School Hannover Germany
Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France
Department of Cardiology Centro Hospitalar Universitário de São João E P E Porto Portugal
Department of Cardiology Chiba Emergency Medical Center Chiba Japan
Department of Cardiology Christchurch Hospital Christchurch New Zealand
Department of Cardiology Heidelberg University Hospital Heidelberg Germany
Department of Cardiology John Radcliffe Hospital Oxford University Hospitals Oxford United Kingdom
Department of Cardiology Kantonsspital Frauenfeld Frauenfeld Switzerland
Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland
Department of Cardiology Kantonsspital St Gallen St Gallen Switzerland
Department of Cardiology Kantonsspital Winterthur Winterthur Switzerland
Department of Cardiology King's College Hospital London United Kingdom
Department of Cardiology Leiden University Medical Centre Leiden the Netherlands
Department of Cardiology Medical University of Warsaw Warsaw Poland
Department of Cardiology National University Heart Centre Singapore
Department of Cardiology University Hospital Basel Basel Switzerland
Department of Cardiovascular Diseases Mayo Clinic Rochester Minnesota USA
Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan
Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan
Department of Internal Medicine 1 Cardiology University Hospital Olomouc Olomouc Czech Republic
Department of Internal Medicine 2 Cardiology University of Ulm Medical Center Ulm Germany
Department of Internal Medicine Cardiology and Angiology Magdeburg University Magdeburg Germany
Department of Public Health University Federico 2 of Naples Naples Italy
Department of Translational Medical Sciences Federico 2 University Naples Italy
Division of Cardiology A O U San Luigi Gonzaga Orbassano Turin Italy
Division of Cardiology Heart and Vascular Center University of Iowa Iowa City Iowa USA
Division of Cardiology Kimitsu Central Hospital Kisarazu Japan
Division of Cardiology Medical University of Graz Graz Austria
Dorset Heart Centre Royal Bournemouth Hospital Bournemouth United Kingdom
Fondazione Policlinico Universitario A Gemelli IRCCS Università Cattolica Del Sacro Cuore Rome Italy
Heart and Vascular Centre Bad Bevensen Bad Bevensen Germany
Heart Center Turku University Hospital and University of Turku Turku Finland
Intensive coronary care Unit Moscow City Hospital 1 named after N Pirogov Moscow Russia
Klinik für Innere Medizin 3 Universitätsklinikum des Saarlandes Homburg Saar Germany
Klinik und Poliklinik für Innere Medizin 2 Universitätsklinikum Regensburg Regensburg Germany
Krankenhaus Maria Hilf Medizinische Klinik Stadtlohn Germany
Local Health Unit no 8 Cardiology Unit Arzignano Vicenza Italy
Service de cardiologie Hôpitaux Universitaires de Genève Geneva Switzerland
Structural Interventional Cardiology Careggi University Hospital Florence Italy
TJ Health Partners Heart and Vascular Glasgow Kentucky USA
University Hospital for Internal Medicine 3 Medical University Innsbruck Innsbruck Austria
University of Southern California Keck School of Medicine Los Angeles California USA
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