Mitochondrial DNA damage, repair, and replacement in cancer
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
39438191
DOI
10.1016/j.trecan.2024.09.010
PII: S2405-8033(24)00212-7
Knihovny.cz E-zdroje
- Klíčová slova
- DNA stability, base excision repair, cancer, horizontal mitochondrial transfer, mitochondrial DNA, mitochondrial DNA damage repair, nuclear DNA,
- MeSH
- lidé MeSH
- mitochondriální DNA * genetika metabolismus MeSH
- mitochondrie * genetika patologie metabolismus MeSH
- nádory * genetika patologie MeSH
- oprava DNA * MeSH
- poškození DNA * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- mitochondriální DNA * MeSH
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are structurally more accessible than nuclear DNA (nDNA). While nDNA is typically diploid, the number of mtDNA copies per cell is higher and varies considerably during development and between tissues. Compared with nDNA, mtDNA is more prone to damage that is positively linked to many diseases, including cancer. Similar to nDNA, mtDNA undergoes repair processes, although these mechanisms are less well understood. In this review, we discuss the various forms of mtDNA damage and repair and their association with cancer initiation and progression. We also propose horizontal mitochondrial transfer as a novel mechanism for replacing damaged mtDNA.
Institute of Biotechnology Czech Academy of Sciences 252 50 Prague West Czech Republic
Malaghan Institute of Medical Research Wellington 6242 New Zealand
Citace poskytuje Crossref.org
