History and main activities of the Society for the Treatment of Tobacco Dependence (SLZT) over its 30 years of activity are aimed at pre/postgraduate education of physicians, nurses and pharmacists, it has been involved in the publication of first smoking cessation recommendations, then in 2005, 2015 and 2022 guidelines for treatment of tobacco dependence, has supported payment codes for medical interventions for tobacco dependence treatment and at least minimal contributions from health insurance companies for tobacco dependence medications, and was at the birth of the smoking cessation helpline. SLZT has published and disseminated dozens of patient leaflets focusing on different clinical areas of the impact of smoking, lobbied for better tobacco control legislation, and is involved in the international smoke-free hospitals project (GNTH - The Global Network for Tobacco Free Healthcare Services). It annually awards the SLZT Prize for the dissemination of tobacco dependence treatment in the field. It collaborates with other clinically oriented professional societies as well as the Working Group on Prevention and Treatment of Tobacco Dependence of the Czech Medical Association of J. E. Purkyně.