Diboronate-Modified Hyaluronic Acid for Glucose-Responsive Insulin Delivery
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
- MeSH
- experimentální diabetes mellitus * farmakoterapie MeSH
- glukosa * metabolismus MeSH
- hypoglykemika * aplikace a dávkování chemie MeSH
- inzulin * aplikace a dávkování chemie farmakologie MeSH
- krevní glukóza účinky léků MeSH
- kyselina hyaluronová * chemie MeSH
- kyseliny boronové * chemie MeSH
- lékové transportní systémy * MeSH
- myši MeSH
- nosiče léků * chemie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glukosa * MeSH
- hypoglykemika * MeSH
- inzulin * MeSH
- krevní glukóza MeSH
- kyselina hyaluronová * MeSH
- kyseliny boronové * MeSH
- nosiče léků * MeSH
Diabetes requires precise insulin management to maintain glycemic control and prevent severe complications. Glucose-responsive delivery systems envision an autonomous approach to improve insulin therapy. Here, a glucose-sensitive insulin delivery system comprising hyaluronic acid conjugated with a diboronate glucose binder as a carrier for diol-modified insulin is shown. This approach seeks improved precision in insulin delivery, leveraging bidentate glucose binding to achieve enhanced glucose affinity and specificity. Modification of insulin with a diol motif preserves its native conformation and function. These insulin formulations correct blood glucose in diabetic mice, including glucose-responsive function when subjected to a glucose challenge. However, the absence of secondary interactions, such as electrostatic complexation, ultimately limits the duration of function relative to that of previous platforms. Integrating complementary interactions alongside dynamic-covalent glucose binders therefore enhances the functional duration and therapeutic efficacy in the design of glucose-responsive polymeric carriers, offering design insights into the development of new carriers for glucose-responsive insulin delivery.
Citace poskytuje Crossref.org